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Sleep Disordered Breathing at High Altitude in Adults and Its Interaction with Cardiovascular Homeostasis

Sleep Disordered Breathing at High Altitude in Adults and Its Interaction with Cardiovascular... Purpose of Review Worldwide > 140 million people are living at high altitude and large numbers of lowlanders travel to high altitude for professional reasons or leisure activities. While there is widely held belief that sleep is perturbed at high altitude, little scientific evidence supports this notion. Here, we summarize recent work on sleep at high altitude in newcomers and high-altitude dwellers with particular emphasis on the interactions between sleep-disordered breathing (SDB) and cardiovascular regulation. Recent Findings Recent studies show an interaction between SDB and cardiovascular homeostasis in high-altitude dwellers. In high-altitude dwellers, SDB is associated with pulmonary hypertension and right ventricular dysfunction, premature atheroscle- rosis in the systemic circulation, and altered regulation of the cerebrovascular circulation related with cognitive decline and depression. Summary In high-altitude dwellers, recent studies show a potential role of SDB in promoting cardiovascular morbidity and mortality. There is an urgent need for studies examining the effects of the treatment of SDB on cardiovascular homeostasis and its long-term benefits on cardiovascular morbidity/mortality in high-altitude dwellers. . . . . Keywords Pulmonary artery pressure Arterial hypertension Endothelial function Cerebrovascular function Chronic mountain sickness Introduction altitude dwellers on this topic [2�� ]. The aim of the present http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

Sleep Disordered Breathing at High Altitude in Adults and Its Interaction with Cardiovascular Homeostasis

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Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Nature Switzerland AG
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-019-00138-x
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Worldwide > 140 million people are living at high altitude and large numbers of lowlanders travel to high altitude for professional reasons or leisure activities. While there is widely held belief that sleep is perturbed at high altitude, little scientific evidence supports this notion. Here, we summarize recent work on sleep at high altitude in newcomers and high-altitude dwellers with particular emphasis on the interactions between sleep-disordered breathing (SDB) and cardiovascular regulation. Recent Findings Recent studies show an interaction between SDB and cardiovascular homeostasis in high-altitude dwellers. In high-altitude dwellers, SDB is associated with pulmonary hypertension and right ventricular dysfunction, premature atheroscle- rosis in the systemic circulation, and altered regulation of the cerebrovascular circulation related with cognitive decline and depression. Summary In high-altitude dwellers, recent studies show a potential role of SDB in promoting cardiovascular morbidity and mortality. There is an urgent need for studies examining the effects of the treatment of SDB on cardiovascular homeostasis and its long-term benefits on cardiovascular morbidity/mortality in high-altitude dwellers. . . . . Keywords Pulmonary artery pressure Arterial hypertension Endothelial function Cerebrovascular function Chronic mountain sickness Introduction altitude dwellers on this topic [2�� ]. The aim of the present

Journal

Current Sleep Medicine ReportsSpringer Journals

Published: Apr 22, 2019

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