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Sleep Apnea and Cardiovascular Morbidity—a Perspective

Sleep Apnea and Cardiovascular Morbidity—a Perspective Purpose of Review In this paper, we analyzed the principal mechanisms linking OSA and cardiovascular diseases, the magnitude of this association, and the effect of treatment on cardiovascular risk reduction. Furthermore, we focused on big data and genomic approaches that may expand the innovative horizon aimed at personalized treatment of OSA. Recent Findings Patients with obstructive sleep apnea (OSA) are more prone to suffer from cardiovascular diseases and their complications. Arousal from sleep, changes in intrathoracic pressures, and intermittent episodes of hypoxemia and re- oxygenation trigger intermediate mechanisms that are responsible for the cardiovascular consequences of OSA. Summary The impact of OSA on cardiovascular health, such as the effect of continuous positive airway pressure (CPAP) treatment on cardiovascular risk, may vary among different patient profiles. In spite of increasing interest towards personalized therapy for OSA, observational studies and randomized clinical trials have failed to conclusively determine which OSA pheno- types may benefit most from treatment, particularly in terms of reducing cardiovascular risk. . . . Keywords OSA Cardiovascular disease Cardiovascular risk CPAP Introduction Obstructive Sleep Apnea and Cardiovascular Morbidity: Identifying the Magnitude Cardiovascular diseases are the leading cause of death global- of this Relationship ly, with 17.7 million victims http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

Sleep Apnea and Cardiovascular Morbidity—a Perspective

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References (90)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-018-0108-5
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review In this paper, we analyzed the principal mechanisms linking OSA and cardiovascular diseases, the magnitude of this association, and the effect of treatment on cardiovascular risk reduction. Furthermore, we focused on big data and genomic approaches that may expand the innovative horizon aimed at personalized treatment of OSA. Recent Findings Patients with obstructive sleep apnea (OSA) are more prone to suffer from cardiovascular diseases and their complications. Arousal from sleep, changes in intrathoracic pressures, and intermittent episodes of hypoxemia and re- oxygenation trigger intermediate mechanisms that are responsible for the cardiovascular consequences of OSA. Summary The impact of OSA on cardiovascular health, such as the effect of continuous positive airway pressure (CPAP) treatment on cardiovascular risk, may vary among different patient profiles. In spite of increasing interest towards personalized therapy for OSA, observational studies and randomized clinical trials have failed to conclusively determine which OSA pheno- types may benefit most from treatment, particularly in terms of reducing cardiovascular risk. . . . Keywords OSA Cardiovascular disease Cardiovascular risk CPAP Introduction Obstructive Sleep Apnea and Cardiovascular Morbidity: Identifying the Magnitude Cardiovascular diseases are the leading cause of death global- of this Relationship ly, with 17.7 million victims

Journal

Current Sleep Medicine Reports – Springer Journals

Published: Feb 22, 2018

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