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Sleep and Circadian Alterations and the Gut Microbiome: Associations or Causality?

Sleep and Circadian Alterations and the Gut Microbiome: Associations or Causality? Purpose of Review This short review is aimed at presenting the most recent literature investigating the potential causal links between alterations in sleep/circadian cycle and changes in the gut microbiota. Recent Findings Data in mice and humans indicate that sleep disturbances modify the gut microbiota and that pre/probiotic- induced alterations of the microbiota disrupt sleep architecture. Moreover, data in rodents and preliminary results in humans indicate that by either environmentally altering the light/dark cycle or by genetically modifying the circadian system, alterations in gut microbiota will occur. Furthermore, bidirectional interactions between the circadian and hypoxic response systems have emerged, suggesting that the circadian clock could protect against heart attacks. Summary Taken together, the current and still scarce cumulative evidence clearly reinforces the concept that improved under- standing of the role played by the gut microbiome in sleep diseases may potentially contribute to devising future treatments of sleep disorders via targeted restoration of the microbiota. . . . . . Keywords Sleepbreathingdisorders Shiftsleep Light/darkcycle Sleepdiseases Host-microbiotainteraction Gutmicrobiota pathophysiology This article is part of the Topical Collection on Sleep and 3D (Cancer, Introduction Cardiovascular, Metabolic Diseases) The fact that the gut microbiota plays a much more important * Núria Farré NFarreLopez@parcdesalutmar.cat http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

Sleep and Circadian Alterations and the Gut Microbiome: Associations or Causality?

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References (55)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-018-0100-0
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review This short review is aimed at presenting the most recent literature investigating the potential causal links between alterations in sleep/circadian cycle and changes in the gut microbiota. Recent Findings Data in mice and humans indicate that sleep disturbances modify the gut microbiota and that pre/probiotic- induced alterations of the microbiota disrupt sleep architecture. Moreover, data in rodents and preliminary results in humans indicate that by either environmentally altering the light/dark cycle or by genetically modifying the circadian system, alterations in gut microbiota will occur. Furthermore, bidirectional interactions between the circadian and hypoxic response systems have emerged, suggesting that the circadian clock could protect against heart attacks. Summary Taken together, the current and still scarce cumulative evidence clearly reinforces the concept that improved under- standing of the role played by the gut microbiome in sleep diseases may potentially contribute to devising future treatments of sleep disorders via targeted restoration of the microbiota. . . . . . Keywords Sleepbreathingdisorders Shiftsleep Light/darkcycle Sleepdiseases Host-microbiotainteraction Gutmicrobiota pathophysiology This article is part of the Topical Collection on Sleep and 3D (Cancer, Introduction Cardiovascular, Metabolic Diseases) The fact that the gut microbiota plays a much more important * Núria Farré NFarreLopez@parcdesalutmar.cat

Journal

Current Sleep Medicine Reports – Springer Journals

Published: Jan 26, 2018

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