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Single-Pill Combination of Perindopril/Indapamide/Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial

Single-Pill Combination of Perindopril/Indapamide/Amlodipine in Patients with Uncontrolled... Cardiol Ther (2017) 6:91–104 DOI 10.1007/s40119-017-0085-7 ORIGINAL RESEARCH Single-Pill Combination of Perindopril/Indapamide/ Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial Sergey V. Nedogoda Vesna J. Stojanov Received: October 13, 2016 / Published online: February 8, 2017 The Author(s) 2017. This article is published with open access at Springerlink.com (SBP C140 and \160 mmHg and DBP C90 ABSTRACT and\100 mmHg), uncontrolled on maximal dose antihypertensive monotherapy or with a Introduction: Patients with hypertension often single dose of dual therapy. Patients were ran- require a combination of three antihypertensive domly assigned to: single-pill triple combina- agents to achieve blood pressure control, but tion of perindopril 5 mg/indapamide 1.25 mg/ very few single-pill triple combinations are amlodipine 5 mg (Per/Ind/Aml) or dual-pill available. The aim of this study was to deter- combination perindopril 5 mg/indapamide mine whether a single-pill triple combination of 1.25 mg ? amlodipine 5 mg (Per/Ind ? Aml) perindopril, indapamide, and amlodipine was once daily for 12 weeks. The primary endpoint as effective as a dual-pill combination of was change in office supine SBP and DBP from perindopril/indapamide plus separate amlodip- baseline to week 12. The proportion of respon- ine at reducing blood pressure in patients with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiology and Therapy Springer Journals

Single-Pill Combination of Perindopril/Indapamide/Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial

Nedogoda, Sergey; Stojanov, Vesna
Cardiology and Therapy , Volume 6 (1) – Feb 8, 2017
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References (66)

Publisher
Springer Journals
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine; Cardiology
ISSN
2193-8261
eISSN
2193-6544
DOI
10.1007/s40119-017-0085-7
Publisher site
See Article on Publisher Site

Abstract

Cardiol Ther (2017) 6:91–104 DOI 10.1007/s40119-017-0085-7 ORIGINAL RESEARCH Single-Pill Combination of Perindopril/Indapamide/ Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial Sergey V. Nedogoda Vesna J. Stojanov Received: October 13, 2016 / Published online: February 8, 2017 The Author(s) 2017. This article is published with open access at Springerlink.com (SBP C140 and \160 mmHg and DBP C90 ABSTRACT and\100 mmHg), uncontrolled on maximal dose antihypertensive monotherapy or with a Introduction: Patients with hypertension often single dose of dual therapy. Patients were ran- require a combination of three antihypertensive domly assigned to: single-pill triple combina- agents to achieve blood pressure control, but tion of perindopril 5 mg/indapamide 1.25 mg/ very few single-pill triple combinations are amlodipine 5 mg (Per/Ind/Aml) or dual-pill available. The aim of this study was to deter- combination perindopril 5 mg/indapamide mine whether a single-pill triple combination of 1.25 mg ? amlodipine 5 mg (Per/Ind ? Aml) perindopril, indapamide, and amlodipine was once daily for 12 weeks. The primary endpoint as effective as a dual-pill combination of was change in office supine SBP and DBP from perindopril/indapamide plus separate amlodip- baseline to week 12. The proportion of respon- ine at reducing blood pressure in patients with

Journal

Cardiology and Therapy – Springer Journals

Published: Feb 8, 2017

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