Access the full text.
Sign up today, get DeepDyve free for 14 days.
W. Sheehan, W. Phipatanakul (2015)
Difficult-to-control asthma: epidemiology and its link with environmental factorsCurrent Opinion in Allergy and Clinical Immunology, 15
J. Corren, R. Lemanske, N. Hanania, P. Korenblat, M. Parsey, J. Arron, Jeffrey Harris, H. Scheerens, Lawren Wu, Zheng Su, Sofia Mosesova, M. Eisner, Sean Bohen, J. Matthews (2011)
Lebrikizumab treatment in adults with asthma.The New England journal of medicine, 365 12
B. Lanier, T. Bridges, M. Kulus, A. Taylor, I. Berhane, C. Vidaurre (2009)
Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma.The Journal of allergy and clinical immunology, 124 6
R. Sehmi, Steven Smith, M. Kjarsgaard, K. Radford, L. Boulet, C. Lemière, C. Prazma, Hector Ortega, James Martin, P. Nair (2016)
Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone‐dependent severe asthmaClinical & Experimental Allergy, 46
Hector Ortega, Mark Liu, I. Pavord, Guy Brusselle, J. FitzGerald, A. Chetta, M. Humbert, Lynn Katz, O. Keene, Steve Yancey, P. Chanez (2014)
Mepolizumab treatment in patients with severe eosinophilic asthma.The New England journal of medicine, 371 13
Kayleigh Kew, C. Karner, Stephanie Mindus, G. Ferrara (2013)
Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.The Cochrane database of systematic reviews, 12
R. Covar, S. Szefler, Richard Martin, D. Sundstrom, P. Silkoff, James Murphy, D. Young, J. Spahn (2003)
Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.The Journal of pediatrics, 142 5
D. Shaw, A. Sousa, S. Fowler, L. Fleming, G. Roberts, J. Corfield, I. Pandis, A. Bansal, E. Bel, C. Auffray, C. Compton, H. Bisgaard, E. Bucchioni, M. Caruso, P. Chanez, B. Dahlén, S. Dahlén, Kerry Dyson, U. Frey, T. Geiser, M. Verdier, D. Gibeon, Yi-Ke Guo, S. Hashimoto, G. Hedlin, E. Jeyasingham, P. Hekking, T. Higenbottam, I. Horváth, A. Knox, N. Krug, V. Erpenbeck, L. Larsson, Nikos Lazarinis, J. Matthews, R. Middelveld, P. Montuschi, J. Musial, D. Myles, L. Pahus, T. Sandström, W. Seibold, F. Singer, K. Strandberg, J. Vestbo, N. Vissing, C. Garnier, I. Adcock, S. Wagers, A. Rowe, P. Howarth, A. Wagener, R. Djukanović, P. Sterk, K. Chung (2015)
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohortEuropean Respiratory Journal, 46
G. Chupp, C. Lee, Nizar Jarjour, Y. Shim, C. Holm, Susan He, J. Dziura, J. Reed, A. Coyle, P. Kiener, M. Cullen, M. Grandsaigne, M. Dombret, M. Aubier, M. Pretolani, J. Elias (2007)
A chitinase-like protein in the lung and circulation of patients with severe asthma.The New England journal of medicine, 357 20
Grant Keeney, M. Gray, Andrea Morrison, M. Levas, E. Kessler, G. Hill, M. Gorelick, J. Jackson (2014)
Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysisPediatrics, 133
S. Turner, K. Richardson, C. Murray, M. Thomas, E. Hillyer, A. Burden, D. Price (2017)
Long-Acting β-Agonist in Combination or Separate Inhaler as Step-Up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids.The journal of allergy and clinical immunology. In practice, 5 1
M. Uchida, H. Shiraishi, S. Ohta, K. Arima, K. Taniguchi, Shoichi Suzuki, M. Okamoto, S. Ahlfeld, K. Ohshima, S. Kato, S. Toda, H. Sagara, H. Aizawa, T. Hoshino, S. Conway, S. Hayashi, K. Izuhara (2012)
Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis.American journal of respiratory cell and molecular biology, 46 5
C. Vogelberg, P. Moroni-Zentgraf, Miglė Leonavičiūtė-Klimantavičienė, R. Sigmund, E. Hamelmann, M. Engel, S. Szefler (2015)
A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroidsRespiratory Research, 16
Takashi Inoue, K. Akashi, Masako Watanabe, Y. Ikeda, S. Ashizuka, Takanori Motoki, Ryohei Suzuki, N. Sagara, N. Yanagida, Sakura Sato, M. Ebisawa, S. Ohta, J. Ono, K. Izuhara, T. Katsunuma (2016)
Periostin as a biomarker for the diagnosis of pediatric asthmaPediatric Allergy and Immunology, 27
J. Konradsen, A. James, B. Nordlund, Lovisa Reinius, C. Söderhäll, E. Mélen, Å. Wheelock, Karin Carlsen, M. Lidegran, M. Verhoek, R. Boot, B. Dahlén, S. Dahlén, G. Hedlin (2013)
The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma.The Journal of allergy and clinical immunology, 132 2
A. Deschildre, C. Marguet, J. Salleron, I. Pin, J. Rittié, J. Derelle, R. Taam, M. Fayon, J. Brouard, J. Dubus, D. Siret, L. Weiss, G. Pouessel, L. Béghin, J. Just (2013)
Add-on omalizumab in children with severe allergic asthma: a 1-year real life surveyEuropean Respiratory Journal, 42
S. Castanhinha, R. Sherburn, S. Walker, Atul Gupta, C. Bossley, James Buckley, N. Ullmann, R. Grychtol, G. Campbell, M. Maglione, S. Koo, L. Fleming, L. Gregory, R. Snelgrove, A. Bush, C. Lloyd, S. Saglani (2015)
Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33The Journal of Allergy and Clinical Immunology, 136
M. Schee, Rochelle Palmay, J. Cowan, D. Taylor (2013)
Predicting steroid responsiveness in patients with asthma using exhaled breath profilingClinical & Experimental Allergy, 43
G. Takayama, K. Arima, T. Kanaji, S. Toda, Hiroyuki Tanaka, S. Shoji, A. McKenzie, H. Nagai, T. Hotokebuchi, K. Izuhara (2006)
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.The Journal of allergy and clinical immunology, 118 1
S. Vahlkvist, M. Sinding, Kirsten Skamstrup, H. Bisgaard (2006)
Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure.The Journal of allergy and clinical immunology, 117 6
A. Deschildre, C. Marguet, C. Langlois, I. Pin, J. Rittié, J. Derelle, R. Taam, M. Fayon, J. Brouard, J. Dubus, D. Siret, L. Weiss, G. Pouessel, L. Béghin, J. Just (2015)
Real-life long-term omalizumab therapy in children with severe allergic asthmaEuropean Respiratory Journal, 46
H. Kerstjens, M. Engel, R. Dahl, P. Paggiaro, E. Beck, M. Vandewalker, R. Sigmund, W. Seibold, P. Moroni-Zentgraf, E. Bateman (2012)
Tiotropium in asthma poorly controlled with standard combination therapy.The New England journal of medicine, 367 13
C. Brightling, P. Chanez, R. Leigh, P. O'Byrne, S. Korn, D. She, R. May, K. Streicher, K. Ranade, E. Piper (2015)
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.The Lancet. Respiratory medicine, 3 9
L. Denlinger, B. Phillips, Sima Ramratnam, K. Ross, N. Bhakta, J. Cardet, M. Castro, S. Peters, W. Phipatanakul, S. Aujla, L. Bacharier, E. Bleecker, S. Comhair, A. Coverstone, M. DeBoer, S. Erzurum, S. Fain, M. Fajt, A. Fitzpatrick, J. Gaffin, B. Gaston, A. Hastie, G. Hawkins, F. Holguin, A. Irani, E. Israel, B. Levy, N. Ly, D. Meyers, W. Moore, Ross Myers, M. Opina, M. Peters, M. Schiebler, R. Sorkness, Gerald Teague, S. Wenzel, P. Woodruff, D. Mauger, J. Fahy, N. Jarjour (2016)
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent ExacerbationsAmerican Journal of Respiratory and Critical Care Medicine, 195
G. Jia, R. Erickson, D. Choy, Sofia Mosesova, Lawren Wu, O. Solberg, A. Shikotra, R. Carter, Séverine Audusseau, Q. Hamid, P. Bradding, J. Fahy, P. Woodruff, Jeffrey Harris, J. Arron (2011)
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.The Journal of allergy and clinical immunology, 130 3
I. Veen, A. Brinke, S. Gauw, P. Sterk, K. Rabe, E. Bel (2009)
Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study.The Journal of allergy and clinical immunology, 124 3
A. Fitzpatrick, W. Teague, D. Meyers, S. Peters, Xingnan Li, Huashi Li, S. Wenzel, S. Aujla, M. Castro, L. Bacharier, B. Gaston, E. Bleecker, W. Moore (2011)
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program.The Journal of allergy and clinical immunology, 127 2
F. Buchvald, H. Bisgaard (2001)
FeNO measured at fixed exhalation flow rate during controlled tidal breathing in children from the age of 2 yr.American journal of respiratory and critical care medicine, 163 3 Pt 1
F. Schleich, A. Chevremont, V. Paulus, M. Henket, M. Manise, L. Seidel, R. Louis (2014)
Importance of concomitant local and systemic eosinophilia in uncontrolled asthmaEuropean Respiratory Journal, 44
S. Teach, M. Gill, A. Togias, C. Sorkness, S. Arbes, A. Calatroni, J. Wildfire, P. Gergen, R. Cohen, J. Pongracic, C. Kercsmar, G. Hershey, R. Gruchalla, A. Liu, E. Zoratti, M. Kattan, K. Grindle, J. Gern, W. Busse, S. Szefler (2015)
Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.The Journal of allergy and clinical immunology, 136 6
Krzysztof Specjalski, E. Jassem (2011)
YKL-40 Protein is a Marker of AsthmaJournal of Asthma, 48
H. Milgrom, W. Berger, A. Nayak, N. Gupta, S. Pollard, M. McAlary, A. Taylor, P. Rohane (2001)
Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab).Pediatrics, 108 2
J. Fahy (2009)
Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies.Proceedings of the American Thoracic Society, 6 3
R. Covar, J. Spahn, James Murphy, S. Szefler (2004)
Progression of asthma measured by lung function in the childhood asthma management program.American journal of respiratory and critical care medicine, 170 3
W. Busse, W. Morgan, P. Gergen, H. Mitchell, J. Gern, A. Liu, R. Gruchalla, M. Kattan, S. Teach, J. Pongracic, J. Chmiel, S. Steinbach, A. Calatroni, A. Togias, K. Thompson, S. Szefler, C. Sorkness (2011)
Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.The New England journal of medicine, 364 11
J. Henderson, R. Granell, Jon Heron, A. Sherriff, A. Simpson, A. Woodcock, D. Strachan, S. Shaheen, J. Sterne (2008)
Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhoodThorax, 63
C. Vogelberg, M. Engel, P. Moroni-Zentgraf, Miglė Leonavičiūtė-Klimantavičienė, R. Sigmund, J. Downie, K. Nething, Viktorija Vevere, M. Vandewalker (2014)
Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: a randomised dose-ranging study.Respiratory medicine, 108 9
Halie Anderson, R. Lemanske, J. Arron, C. Holweg, V. Rajamanickam, R. Gangnon, J. Gern, D. Jackson (2017)
Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma developmentThe Journal of Allergy and Clinical Immunology, 139
M. McGeachie, Katherine Yates, Xiaobo Zhou, F. Guo, A. Sternberg, M. Natta, R. Wise, S. Szefler, Sunita Sharma, A. Kho, M. Cho, Damien Croteau-Chonka, P. Castaldi, Gaurav Jain, Amartya Sanyal, Amartya Sanyal, Y. Zhan, B. Lajoie, B. Lajoie, J. Dekker, J. Stamatoyannopoulos, R. Covar, R. Covar, R. Zeiger, R. Zeiger, N. Adkinson, Paul Williams, H. Kelly, H. Grasemann, J. Vonk, G. Koppelman, D. Postma, B. Raby, I. Houston, Q. Lu, A. Fuhlbrigge, K. Tantisira, E. Silverman, James Tonascia, S. Weiss, R. Strunk (2016)
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma.The New England journal of medicine, 374 19
Aniela Pruteanu, Bhupendrasinh Chauhan, Linjie Zhang, Sílvio Prietsch, F. Ducharme (2014)
Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth.Evidence-based child health : a Cochrane review journal, 9 4
Parameswaran Nair, M. Pizzichini, M. Kjarsgaard, M. Inman, A. Efthimiadis, E. Pizzichini, F. Hargreave, P. O'Byrne (2009)
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia.The New England journal of medicine, 360 10
L. Baden, G. Curfman, S. Morrissey, J. Drazen (2007)
Human papillomavirus vaccine--opportunity and challenge.The New England journal of medicine, 356 19
S. Holgate, T. Casale, S. Wenzel, J. Bousquet, Y. Deniz, C. Reisner (2005)
The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation.The Journal of allergy and clinical immunology, 115 3
Robert Zeiger, Robert Zeiger, D. Mauger, L. Bacharier, T. Guilbert, F. Martinez, R. Lemanske, R. Strunk, R. Covar, S. Szefler, S. Boehmer, D. Jackson, C. Sorkness, J. Gern, H. Kelly, N. Friedman, M. Mellon, M. Schatz, M. Schatz, W. Morgan, V. Chinchilli, H. Raissy, Elizabeth Bade, J. Malka-Rais, A. Beigelman, L. Taussig (2011)
Daily or intermittent budesonide in preschool children with recurrent wheezing.The New England journal of medicine, 365 21
W. Busse, J. Corren, B. Lanier, M. McAlary, A. FowlerTaylor, G. Cioppa, A. As, N. Gupta (2001)
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma.The Journal of allergy and clinical immunology, 108 2
W. Berger, N. Gupta, M. McAlary, A. Fowler-Taylor (2003)
Evaluation of long-term safety of the anti-IgE antibody, omalizumab, in children with allergic asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 91 2
P. Silkoff, F. Romero, N. Gupta, R. Townley, H. Milgrom (2004)
Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody.Pediatrics, 113 4
S. Willsie (2010)
Mepolizumab and Exacerbations of Refractory Eosinophilic AsthmaYearbook of Pulmonary Disease, 2010
M. Humbert, W. Busse, N. Hanania, P. Lowe, J. Canvin, V. Erpenbeck, S. Holgate (2014)
Omalizumab in asthma: an update on recent developments.The journal of allergy and clinical immunology. In practice, 2 5
B. Chipps, R. Zeiger, L. Borish, S. Wenzel, A. Yegin, M. Hayden, Dave Miller, E. Bleecker, F. Simons, S. Szefler, S. Weiss, T. Haselkorn (2012)
Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.The Journal of allergy and clinical immunology, 130 2
C. Robroeks, J. Berkel, Q. Jöbsis, F. Schooten, J. Dallinga, E. Wouters, E. Dompeling (2013)
Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective studyEuropean Respiratory Journal, 42
C. Randolph, Sears Mr, Greene Jm, Willan Engl, B. Chipps, Y. K., Davis Kj, Davis J, Peden D, Shy Respir (2003)
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood.The New England journal of medicine, 349 15
J. Konradsen, E. Skantz, B. Nordlund, M. Lidegran, A. James, J. Ono, S. Ohta, K. Izuhara, S. Dahlén, K. Alving, G. Hedlin (2015)
Predicting asthma morbidity in children using proposed markers of Th2‐type inflammationPediatric Allergy and Immunology, 26
T. Higaki, Mitsuhiro Okano, T. Fujiwara, S. Makihara, S. Kariya, Yohei Noda, Takenori Haruna, Kazunori Nishizaki (2012)
COX/PGE2 axis critically regulates effects of LPS on eosinophilia‐associated cytokine production in nasal polypsClinical & Experimental Allergy, 42
D. Agrawal, Z. Shao (2010)
Pathogenesis of Allergic Airway InflammationCurrent Allergy and Asthma Reports, 10
J. Pongracic, R. Krouse, D. Babineau, E. Zoratti, R. Cohen, R. Wood, G. Hershey, C. Kercsmar, R. Gruchalla, M. Kattan, S. Teach, C. Johnson, L. Bacharier, J. Gern, Steve Sigelman, P. Gergen, A. Togias, C. Visness, W. Busse, A. Liu (2016)
Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.The Journal of allergy and clinical immunology, 138 4
C. Ulrik (1995)
Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthmaClinical & Experimental Allergy, 25
S. Saglani, C. Lloyd (2014)
Eosinophils in the pathogenesis of paediatric severe asthmaCurrent Opinion in Allergy and Clinical Immunology, 14
R. Nadif, Valérie Siroux, M. Oryszczyn, C. Ravault, C. Pison, I. Pin, Francine Kauffmann (2009)
Heterogeneity of asthma according to blood inflammatory patternsThorax, 64
R. Dweik, R. Sorkness, S. Wenzel, J. Hammel, D. Curran-Everett, S. Comhair, E. Bleecker, W. Busse, W. Calhoun, M. Castro, K. Chung, E. Israel, N. Jarjour, W. Moore, S. Peters, Gerald Teague, B. Gaston, S. Erzurum (2010)
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma.American journal of respiratory and critical care medicine, 181 10
(2009)
Blood eosinophils as markers of inflammation in asthma
L. Taussig, A. Wright, C. Holberg, M. Halonen, W. Morgan, F. Martinez (2003)
Tucson Children's Respiratory Study: 1980 to present.The Journal of allergy and clinical immunology, 111 4
E. Hamelmann, E. Bateman, C. Vogelberg, S. Szefler, M. Vandewalker, P. Moroni-Zentgraf, M. Avis, A. Unseld, M. Engel, A. Boner (2016)
Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial.The Journal of allergy and clinical immunology, 138 2
J. Jones, S. Hopkinson (2010)
Faculty Opinions recommendation of Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.
K. Alving, A. Malinovschi (2010)
Basic aspects of exhaled nitric oxideEuropean Respiratory Monograph, 49
A. Fitzpatrick (2016)
Severe Asthma in Children: Lessons Learned and Future Directions.The journal of allergy and clinical immunology. In practice, 4 1
J. Cronin, S. Mccoy, U. Kennedy, Sinéad Fhailí, A. Wakai, J. Hayden, G. Crispino, M. Barrett, S. Walsh, R. O'Sullivan (2016)
A Randomized Trial of Single-Dose Oral Dexamethasone Versus Multidose Prednisolone for Acute Exacerbations of Asthma in Children Who Attend the Emergency Department.Annals of emergency medicine, 67 5
S. Holgate (2011)
Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?The Journal of allergy and clinical immunology, 128 3
D. MacGlashan, B. Bochner, D. Adelman, P. Jardieu, A. Togias, J. McKenzie-White, S. Sterbinsky, R. Hamilton, L. Lichtenstein (1997)
Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.Journal of immunology, 158 3
A. Tai, Haily Tran, M. Roberts, Nadeene Clarke, A. Gibson, S. Vidmar, John Wilson, C. Robertson (2014)
Outcomes of childhood asthma to the age of 50 years.The Journal of allergy and clinical immunology, 133 6
A. Long, Abdelkader Rahmaoui, K. Rothman, E. Guinan, M. Eisner, Mary Bradley, C. Iribarren, Hubert Chen, G. Carrigan, K. Rosen, S. Szefler (2014)
Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab.The Journal of allergy and clinical immunology, 134 3
H. Petsky, C. Cates, T. Lasserson, A. Li, C. Turner, J. Kynaston, A. Chang (2010)
A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)Thorax, 67
S. Sidhu, Shaopeng Yuan, Anh Innes, S. Kerr, P. Woodruff, L. Hou, S. Muller, J. Fahy (2010)
Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthmaProceedings of the National Academy of Sciences, 107
R. Pauwels (1996)
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION, 45
H. Ortega, G. Chupp, P. Bardin, A. Bourdin, Gilles Garcia, B. Hartley, S. Yancey, M. Humbert (2014)
The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophiliaEuropean Respiratory Journal, 44
L. Fleming, C. Murray, A. Bansal, S. Hashimoto, H. Bisgaard, A. Bush, U. Frey, G. Hedlin, F. Singer, W. Aalderen, N. Vissing, Z. Zolkipli, A. Selby, S. Fowler, D. Shaw, K. Chung, A. Sousa, S. Wagers, J. Corfield, I. Pandis, A. Rowe, E. Formaggio, P. Sterk, G. Roberts (2015)
The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohortsEuropean Respiratory Journal, 46
H. Bisgaard, P. Roux, Ditlef Bjåmer, A. Dymek, J. Vermeulen, C. Hultquist (2006)
Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma.Chest, 130 6
E. Bel, S. Wenzel, P. Thompson, C. Prazma, O. Keene, S. Yancey, H. Ortega, I. Pavord (2014)
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.The New England journal of medicine, 371 13
W. Kanchongkittiphon, W. Phipatanakul (2014)
Exhaled Volatile Organic Compounds Predict Exacerbations of Childhood Asthma in a 1-Year Prospective StudyPediatrics, 134
C. Svanes, J. Sunyer, E. Plana, S. Dharmage, J. Heinrich, D. Jarvis, R. Marco, D. Norbäck, C. Raherison, S. Villani, M. Wjst, K. Svanes, J. Antó (2009)
Early life origins of chronic obstructive pulmonary diseaseThorax, 65
Curr Allergy Asthma Rep (2017) 17: 21 DOI 10.1007/s11882-017-0688-z PEDIATRIC ALLERGY AND IMMUNOLOGY (W DOLEN, SECTION EDITOR) 1 1 1 Bradley E. Chipps & Neil G. Parikh & Sheena K. Maharaj Published online: 28 March 2017 Springer Science+Business Media New York 2017 Abstract persistent. Currently, available treatments have not been Purpose of Review The aim of this study is to characterize, shown to provide disease modification. diagnose, evaluate, and treat severe childhood asthma. Recent Findings Understanding the occurrence of the physi- ologic and clinical presentations of childhood severe asthma, Natural History of Severe Asthma the treatment and response may be predicted by biomarkers, but the patient’s response is highly variable. Asthmaaffectsnearly6millionchildrenintheUSA Summary The onset of severe asthma occurs early and is pri- approximately 10% of children less than 15 years of marily predicted by severity of viral infection and coexistence age. A total of 5–10% of these children have severe or of the atopic state. difficult-to-treat asthma. The medical expenditure for asthma is approximately 10 billion annually with severe . . . Keywords Severe asthma Childhood asthma Biomarkers asthma accounting for up to 50% of these costs. The Biologic therapy Pharmacologic therapy National Heart, Lung and Blood Institute’sSevere Asthma
Current Allergy and Asthma Reports – Springer Journals
Published: Mar 28, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.