Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Serum neutrophil gelatinase-associated lipocalin and cystatin C as markers of renal function in patients with stages 2–5 chronic kidney disease

Serum neutrophil gelatinase-associated lipocalin and cystatin C as markers of renal function in... Individuals with reduced glomerular filtration rate (GFR) are at greater risk for cardiovascular disease and other comorbidities. Creatinine-based equations are used to estimate GFR, identify patients with potential kidney disease, and classify them into different stages since serum creatinine is insensitive to changes in the GFR. The aim of our work was to evaluate diagnostic performance of serum cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as markers of kidney function in patients with reduced GFR. Fifty cases at different stages of renal impairment and 30 healthy control subjects were tested. Only serum NGAL and cystatin C were higher in stage 2 chronic kidney disease (CKD) when compared to the control group (p < 0.05). For stages 3–5 the median levels of cystatin C, NGAL, and creatinine were found to be significantly higher than the control group. ROC curve constructed to differentiate stage 2 patients from the controls showed AUC for NGAL 0.795, sensitivity 86%, and specificity 63.3%; AUC for cystatin C 0.957, sensitivity 86%, and specificity 90%; and AUC for creatinine 0.738. Frequency of cases that tested positive for NGAL and cystatin C in stage 2 was higher than those in control group (p < 0.05) with an OR of 10.364 (95% CI 1.099–97.686) for NGAL and OR 54 (95% CI 4.7–613) for cystatin C. NGAL and cystatin C exhibited higher sensitivity than creatinine for diagnosis of stage 2 CKD. Their use as adjunctive diagnostic tools in patients with mildly reduced GFR may be justified on the long term to diagnose early renal insult. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Serum neutrophil gelatinase-associated lipocalin and cystatin C as markers of renal function in patients with stages 2–5 chronic kidney disease

Download PDF
8 pages

Loading next page...
 
/lp/springer-journals/serum-neutrophil-gelatinase-associated-lipocalin-and-cystatin-c-as-xFj8tQYyd4
Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-011-1404-3
Publisher site
See Article on Publisher Site

Abstract

Individuals with reduced glomerular filtration rate (GFR) are at greater risk for cardiovascular disease and other comorbidities. Creatinine-based equations are used to estimate GFR, identify patients with potential kidney disease, and classify them into different stages since serum creatinine is insensitive to changes in the GFR. The aim of our work was to evaluate diagnostic performance of serum cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as markers of kidney function in patients with reduced GFR. Fifty cases at different stages of renal impairment and 30 healthy control subjects were tested. Only serum NGAL and cystatin C were higher in stage 2 chronic kidney disease (CKD) when compared to the control group (p < 0.05). For stages 3–5 the median levels of cystatin C, NGAL, and creatinine were found to be significantly higher than the control group. ROC curve constructed to differentiate stage 2 patients from the controls showed AUC for NGAL 0.795, sensitivity 86%, and specificity 63.3%; AUC for cystatin C 0.957, sensitivity 86%, and specificity 90%; and AUC for creatinine 0.738. Frequency of cases that tested positive for NGAL and cystatin C in stage 2 was higher than those in control group (p < 0.05) with an OR of 10.364 (95% CI 1.099–97.686) for NGAL and OR 54 (95% CI 4.7–613) for cystatin C. NGAL and cystatin C exhibited higher sensitivity than creatinine for diagnosis of stage 2 CKD. Their use as adjunctive diagnostic tools in patients with mildly reduced GFR may be justified on the long term to diagnose early renal insult.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Jan 4, 2012

References

  • Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
    Bachorzewska-Gajewska, H; Malyszko, J; Sitniewska, E; Malyszko, JS; Pawlak, K; Mysliwiec, M
  • Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Bennett, M; Dent, CL; Ma, Q; Dastrala, S; Grenier, F; Workman, R
  • Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) in macroproteinuric patients with worsening renal function
    Bolignano, D; Coppolino, G; Lacquaniti, A; Nicocia, G; Buemi, M
  • Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury
    Devarajan, P
  • Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Dharnidharka, VR; Kwon, C; Stevens, G
  • Urinary neutrophil gelatinase-associated lipocalin is an early biomarker for renal tubulointerstitial injury in IgA nephropathy
    Ding, H; He, Y; Li, K; Yang, J; Li, X; Lu, R; Gao, W
  • Chronic kidney disease progression
    Eddy, AA; Neilson, EG
  • Cystatin C as a marker of GFR—history, indications, and future research
    Filler, G; Bokenkamp, A; Hofmann, W; Bricon, TL; Grubb, A
  • Adult reference for serum cystatin C, creatinine and predicted creatinine clearance
    Finney, H; Newman, DJ; Price, CP
  • The lipocalin protein family: structural and sequence overview
    Flower, DR; North, AC; Sansom, CE
  • Age, gender, and race effects on cystatin C levels in US adolescents
    Groesbeck, D; Köttgen, A; Parekh, R; Selvin, E; Schwartz, GJ; Coresh, J
  • A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft–Gault formula
    Grubb, A; Bjork, J; Lindstrom, V; Sterner, G; Bondesson, P; Nyman, U
  • New biomarkers of acute kidney injury and the cardio-renal syndrome
    Hawkins, R
  • Early detection of acute renal failure by serum cystatin C
    Herget-Rosenthal, S; Marggraf, G; Hüsing, J; Göring, F; Pietruck, F; Janssen, O
  • Clinical epidemiology and biostatistics
    Knapp, RG; Miller, MC
  • Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Knight, EL; Verhave, JC; Spiegelman, D; Hillege, HL; Zeeuw, D; Curhan, GC
  • Tietz text book of clinical chemistry
    Lamb, E; Newman, D; Price, C
  • A simplified equation to predict glomerular filtration rate from serum creatinine
    Levey, AS; Greene, T; Kusek, JW; Beck, GJ; Group, MS
  • Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Levey, AS; Eckardt, KU; Tsukamoto, Y; Levin, A; Coresh, J; Rossert, J; Zeeuw, D; Hostetter, TH; Lameire, N; Eknoyan, G
  • GFR estimation using cystatin C is not independent of body composition
    Macdonald, J; Marcora, S; Jibani, M; Roberts, G; Kumwenda, M; Glover, R
  • Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Makris, K; Markou, N; Evodia, E; Dimopoulou, E; Drakopoulos, I; Ntetsika, K
  • Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in non-diabetic patients with stage 2–4 chronic kidney disease
    Malyszko, J; Bachorzewska-Gajewska, H; Sitniewska, E; Malyszko, JS; Poniatowski, B; Dobrzycki, S
  • Neutrophil gelatinase-associated lipocalin is a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients
    Malyszko, J; Malyszko, JS; Bachorzewska-Gajewska, H; Poniatowski, B; Dobrzycki, S; Mysliwiec, M
  • Level of kidney function as a risk factor for cardiovascular outcomes in the elderly
    Manjunath, G; Tighioaurt, H; Coresh, J; Macleod, B; Salem, DN; Griffith, JL
  • Chronic kidney disease: the global challenge
    Meguid, EL; Nahas, A; Bello, A
  • Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Mishra, J; Ma, Q; Prada, A; Mitsnefes, M; Zahedi, K; Yang, J
  • Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity
    Mishra, J; Mori, K; Ma, Q; Kelly, C; Barasch, J; Devarajan, P
  • Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
    Mori, K; Nakao, K
  • Clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification
  • Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Nickolas, TL; O'Rourke, MJ; Yang, J; Sise, ME; Canetta, PA; Barasch, N
  • The role of renal proximal tubular cells in diabetic nephropathy
    Phillips, AO
  • Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients
    Pucci, L; Triscornia, S; Lucchesi, D; Fotino, C; Pellegrini, G; Pardini, E
  • The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study
    Rowe, JW; Andres, R; Tobin, JD; Norris, AH; Shock, NW
  • Lipocalin-2 development, analytical characterization, and clinical testing of a new ELISA
    Stejskal, D; Karpisek, M; Humenanska, V; Hanulova, Z; Stejskal, P; Kusnierova, P; Petzel, M
  • Chronic kidney disease in the elderly—how to assess risk
    Stevens, LA; Levey, AS
  • Estimation of the initial dose setting of vancomycin therapy using cystatin C as a new marker of renal function
    Tanaka, A; Suemaru, K; Otsuka, T; Ido, K; Nishimiya, T; Sakai, I
  • Cystatin C measurement and its practical use in patients with various renal diseases
    Tian, S; Kusano, E; Ohara, T; Tabei, K; Itoh, Y; Kawai, T; Asano, Y
  • Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass
    Tuladhar, SM; Puntmann, VO; Soni, M; Punjabi, PP; Bogle, RG
  • Reaction of alkaline sodium picrate with creatinine: 1. Kinetics and mechanism of formation of the non creatinine picric acid complex
    Vasiliades, J
  • KIM-1 and NGAL: new markers of obstructive nephropathy
    Wasilewska, A; Taranta-Janusz, K; Dębek, W; Zoch-Zwierz, W; Kuroczycka-Saniutycz, E
  • Serum cystatin C level is a marker of end-organ damage in patients with essential hypertension
    Watanabe, S; Okura, T; Liu, J; Miyoshi, K; Fukuoka, T; Hiwada, K