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Semimicro HPLC as a Tool for Optimizing Organic Synthesis

Semimicro HPLC as a Tool for Optimizing Organic Synthesis Doklady Chemistry, Vol. 381, Nos. 4–6, 2001, pp. 347–348. Translated from Doklady Akademii Nauk, Vol. 381, No. 4, 2001, pp. 506–508. Original Russian Text Copyright © 2001 by Gorshkov, Shmidt, Mikhaleva. CHEMISTRY Semimicro HPLC as a Tool for Optimizing Organic Synthesis A. G. Gorshkov*, E. Yu. Shmidt**, and A. I. Mikhaleva** Presented by Academician B.A. Trofimov July 4, 2001 Received August 6, 2001 High-performance liquid chromatography (HPLC) is quantify starting reagents, target products, and byprod- one of the few analytical methods available for direct ucts in reaction mixtures in 10–15 min. A simple proce- determination of reaction products in reaction mixtures. dure of sample preparation and versatile possibilities of However, despite its obvious advantages, this method is the C18 polymer phase for the analysis of polyfunc- not used properly for monitoring organic syntheses, pre- tional compounds allows one to easily adapt this proce- sumably, because analysis using conventional HPLC dure for the investigation of syntheses and chemical columns (4.6 · 250 mm) is too costly and time consum- transformations of different O- and N-vinyl monomers. ing. The use of semimicro columns (according to the Direct HPLC analysis of reaction mixtures requires classification suggested by Ishi [1]) considerably reduces a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Semimicro HPLC as a Tool for Optimizing Organic Synthesis

Gorshkov, A.; Shmidt, E.; Mikhaleva, A.
Doklady Chemistry , Volume 381 (6) – Oct 12, 2004
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References (2)

Publisher
Springer Journals
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1023/A:1013368808839
Publisher site
See Article on Publisher Site

Abstract

Doklady Chemistry, Vol. 381, Nos. 4–6, 2001, pp. 347–348. Translated from Doklady Akademii Nauk, Vol. 381, No. 4, 2001, pp. 506–508. Original Russian Text Copyright © 2001 by Gorshkov, Shmidt, Mikhaleva. CHEMISTRY Semimicro HPLC as a Tool for Optimizing Organic Synthesis A. G. Gorshkov*, E. Yu. Shmidt**, and A. I. Mikhaleva** Presented by Academician B.A. Trofimov July 4, 2001 Received August 6, 2001 High-performance liquid chromatography (HPLC) is quantify starting reagents, target products, and byprod- one of the few analytical methods available for direct ucts in reaction mixtures in 10–15 min. A simple proce- determination of reaction products in reaction mixtures. dure of sample preparation and versatile possibilities of However, despite its obvious advantages, this method is the C18 polymer phase for the analysis of polyfunc- not used properly for monitoring organic syntheses, pre- tional compounds allows one to easily adapt this proce- sumably, because analysis using conventional HPLC dure for the investigation of syntheses and chemical columns (4.6 · 250 mm) is too costly and time consum- transformations of different O- and N-vinyl monomers. ing. The use of semimicro columns (according to the Direct HPLC analysis of reaction mixtures requires classification suggested by Ishi [1]) considerably reduces a

Journal

Doklady Chemistry – Springer Journals

Published: Oct 12, 2004

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