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Semi-automated methodology for determination of contrast agent relaxivity using MRI

Semi-automated methodology for determination of contrast agent relaxivity using MRI IntroductionKnowledge of the longitudinal and transverse relaxivities (r1 and r2) of a contrast agent (CA) is essential for its magnetic characterization. These parameters can be measured using Magnetic Resonance Imaging (MRI) clinical scanners with the advantage of characterizing the CA under the same experimental conditions where it will be employed. Nevertheless, when using MRI, there are several limitations to consider, and we provide ways to compensate for them to obtain accurate results.Materials and MethodsWe present a fast and robust methodology to determine the relaxivity of CA solutions using a 3 T MRI clinical scanner with a single-channel transmit-receive birdcage coil. We performed relaxivity measurements on a phantom consisting of five samples of copper sulfate at different concentrations.ResultsWe optimized image acquisition for total scan time using three different pulse sequences. Post-processing steps following image acquisition were implemented in a semiautomatic MATLAB toolbox. Relaxation times were estimated using the three-parameter model with the Levenberg-Marquardt algorithm. Statistical comparisons demonstrate good reproducibility and robustness in the relaxivity estimation by each method.ConclusionsThis paper presented a methodology and a systematic discussion of experimental factors associated with relaxivity determination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Biomedical Engineering Springer Journals

Semi-automated methodology for determination of contrast agent relaxivity using MRI

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References (16)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2446-4732
eISSN
2446-4740
DOI
10.1007/s42600-023-00309-4
Publisher site
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Abstract

IntroductionKnowledge of the longitudinal and transverse relaxivities (r1 and r2) of a contrast agent (CA) is essential for its magnetic characterization. These parameters can be measured using Magnetic Resonance Imaging (MRI) clinical scanners with the advantage of characterizing the CA under the same experimental conditions where it will be employed. Nevertheless, when using MRI, there are several limitations to consider, and we provide ways to compensate for them to obtain accurate results.Materials and MethodsWe present a fast and robust methodology to determine the relaxivity of CA solutions using a 3 T MRI clinical scanner with a single-channel transmit-receive birdcage coil. We performed relaxivity measurements on a phantom consisting of five samples of copper sulfate at different concentrations.ResultsWe optimized image acquisition for total scan time using three different pulse sequences. Post-processing steps following image acquisition were implemented in a semiautomatic MATLAB toolbox. Relaxation times were estimated using the three-parameter model with the Levenberg-Marquardt algorithm. Statistical comparisons demonstrate good reproducibility and robustness in the relaxivity estimation by each method.ConclusionsThis paper presented a methodology and a systematic discussion of experimental factors associated with relaxivity determination.

Journal

Research on Biomedical Engineering – Springer Journals

Published: Sep 15, 2023

Keywords: Contrast agent; Relaxivity; Magnetic Resonance Imaging

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