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Seborrheic keratosis with Bowenoid transformation

Seborrheic keratosis with Bowenoid transformation Seborrheic keratosis is a benign epidermal tumor but may transform to malignant lesion in sun-exposed areas of the skin. In current study, we report here a patient who presented with multiple cutaneous horns originating from seborrheic keratosis with Bowenoid transformation on the back of the shoulder as an uncommon site. An 88-year-old Iranian woman presented with a multi-conical keratotic projection lesion (7 × 8 cm) on the back of the left shoulder. A biopsy of the lesion revealed intra-epidermal neoplasm that is composed of acanthosis, hyperkeratosis, and parakeratosis. Total thickness of epidermis is composed of atypical squamous cells with foci of individual keratinization, anaplastic cells, and frequent mitosis. Based on the clinical and pathologic findings, we diagnosed this lesion as a cutaneous horn originating from seborrheic keratosis with Bowenoid transformation. Histopathologic examination of all seborrheic keratosis cases should be considered, especially when seborrheic keratosis has atypical clinical manifestations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Seborrheic keratosis with Bowenoid transformation

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References (8)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-014-2042-3
Publisher site
See Article on Publisher Site

Abstract

Seborrheic keratosis is a benign epidermal tumor but may transform to malignant lesion in sun-exposed areas of the skin. In current study, we report here a patient who presented with multiple cutaneous horns originating from seborrheic keratosis with Bowenoid transformation on the back of the shoulder as an uncommon site. An 88-year-old Iranian woman presented with a multi-conical keratotic projection lesion (7 × 8 cm) on the back of the left shoulder. A biopsy of the lesion revealed intra-epidermal neoplasm that is composed of acanthosis, hyperkeratosis, and parakeratosis. Total thickness of epidermis is composed of atypical squamous cells with foci of individual keratinization, anaplastic cells, and frequent mitosis. Based on the clinical and pathologic findings, we diagnosed this lesion as a cutaneous horn originating from seborrheic keratosis with Bowenoid transformation. Histopathologic examination of all seborrheic keratosis cases should be considered, especially when seborrheic keratosis has atypical clinical manifestations.

Journal

Comparative Clinical PathologySpringer Journals

Published: Mar 4, 2015

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