Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/sdha-a-key-player-in-t-cell-mediated-intestinal-disease-severity-06D5GZGLJj
References (10)
-
Gulistan Agirman, Kristie Yu, E. Hsiao (2021)
Signaling inflammation across the gut-brain axisScience, 374
-
B. Parfait, D. Chrétien, A. Rötig, C. Marsac, Arnold Munnich, P. Rustin (2000)
Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndromeHuman Genetics, 106
-
H Fujiwara (2021)
1440Nat Immunol, 22
-
T. Bourgeron, P. Rustin, D. Chrétien, M. Birch‐Machin, M. Bourgeois, E. Viégas-Péquignot, A. Munnich, A. Rötig (1995)
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiencyNature Genetics, 11
-
M. Selak, S. Armour, Elaine MacKenzie, Houda Boulahbel, D. Watson, K. Mansfield, Yi Pan, M. Simon, C. Thompson, E. Gottlieb (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylaseCancer Cell, 7
-
(2021)
Nat Commun -
Kelsey Voss, H. Hong, Jackie Bader, Ayaka Sugiura, C. Lyssiotis, J. Rathmell (2021)
A guide to interrogating immunometabolismNature Reviews Immunology, 21
-
I. Martínez-Reyes, N. Chandel (2020)
Mitochondrial TCA cycle metabolites control physiology and diseaseNature Communications, 11
-
Elisabeth Urbauer, E. Rath, D. Haller (2021)
Mitochondrial Metabolism in the Intestinal Stem Cell Niche—Sensing and Signaling in Health and DiseaseFrontiers in Cell and Developmental Biology, 8
-
Hideaki Fujiwara, A. Mathew, I. Kovalenko, Anupama Pal, Ho-Joon Lee, Daniel Peltier, Stephanie Kim, Chen Liu, K. Oravecz-Wilson, Lu Li, Yaping Sun, Jaeman Byun, Thomas Saunders, A. Rehemtulla, C. Lyssiotis, Subramanian Pennarthur, P. Reddy (2020)
Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated ImmunopathologybioRxiv
- Publisher
- Springer Journals
- Copyright
- Copyright © The Author(s), under exclusive licence to CSI and USTC 2021
- ISSN
- 1672-7681
- eISSN
- 2042-0226
- DOI
- 10.1038/s41423-021-00820-7
- Publisher site
- See Article on Publisher Site
Abstract
www.nature.com/cmi RESEARCH HIGHLIGHT José M. Izquierdo © The Author(s), under exclusive licence to CSI and USTC 2021 Cellular & Molecular Immunology (2022) 19:139–141; https://doi.org/10.1038/s41423-021-00820-7 In their recent article in Nature Immunology, Fujiwara et al. in IECs from all groups, suggesting that the glycolysis flux was identified reduced mitochondrial respiration and increased succi- refractory, which was confirmed by metabolic isotopic labeling of nate levels in intestinal epithelial cells (IECs) from several distinct glycolysis. To determine the mechanism resulting in the increased models of T cell-mediated colitis. Their observations point to a succinate, the authors experimentally eliminated the contributions specific link between alterations in the mitochondrial complex II of glucose and glutamine anaplerosis and β-oxidation. The component SDHA and the severity of T cell-mediated intestinal researchers hypothesized that the elevated succinate resulted diseases and suggest that SDHA dysfunction could be a diagnostic from the downregulation of SDHA, which catalyzes the oxidation and/or prognostic biomarker in T cell-mediated immunopathology. of succinate to fumarate and generates FADH in the electron Unique metabolic phenotypes are characteristic of several transport chain (ETC). Analysis of SDHA activity in cryosections of human pathologies, which is hardly surprising given the known GVHD target tissues revealed a decrease in
Journal
Cellular & Molecular Immunology – Springer Journals
Published: Feb 1, 2022