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Role of the Microbiome in Food Allergy

Role of the Microbiome in Food Allergy Purpose of Review Resident microbial communities likely modify risk for allergic disorders, including food allergy. We review epidemiologic studies linking microbial exposures to food allergy risk and discuss the mechanisms by which the microbiome may modulate oral tolerance. We additionally address ongoing translational efforts in human microbiome studies. Recent Findings Epidemiologic studies and murine models support that altered microbial exposures and colonization in early life modify food allergy risk. Differential microbiota confer protection or susceptibility to food allergy by modulating the regulatory tone of the mucosal immune system. Recent efforts are focused on the identification of bacterial strains necessary for oral tolerance in human and microbial-based clinical trials. Summary Early childhood appears to be critical for the colonization of a diverse microbiota necessary for the induction and maintenance of oral tolerance. Identification and functional evaluation of protective commensal microbes will inform strategies for the prevention and treatment of food allergy. . . . . . Keywords Food allergy Microbiome Microbiota Peanut allergy Probiotics Oral tolerance Introduction dissecting host-microbial relationships in food allergy, with the idea that manipulating microbial communities to the host’s The prevalence of IgE-mediated food allergy has increased advantage could help prevent and/or treat food allergy. Here, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Role of the Microbiome in Food Allergy

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References (78)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-018-0780-z
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Resident microbial communities likely modify risk for allergic disorders, including food allergy. We review epidemiologic studies linking microbial exposures to food allergy risk and discuss the mechanisms by which the microbiome may modulate oral tolerance. We additionally address ongoing translational efforts in human microbiome studies. Recent Findings Epidemiologic studies and murine models support that altered microbial exposures and colonization in early life modify food allergy risk. Differential microbiota confer protection or susceptibility to food allergy by modulating the regulatory tone of the mucosal immune system. Recent efforts are focused on the identification of bacterial strains necessary for oral tolerance in human and microbial-based clinical trials. Summary Early childhood appears to be critical for the colonization of a diverse microbiota necessary for the induction and maintenance of oral tolerance. Identification and functional evaluation of protective commensal microbes will inform strategies for the prevention and treatment of food allergy. . . . . . Keywords Food allergy Microbiome Microbiota Peanut allergy Probiotics Oral tolerance Introduction dissecting host-microbial relationships in food allergy, with the idea that manipulating microbial communities to the host’s The prevalence of IgE-mediated food allergy has increased advantage could help prevent and/or treat food allergy. Here,

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: Apr 5, 2018

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