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Cardiol Ther (2018) 7:173–183 https://doi.org/10.1007/s40119-018-0117-y ORIGINAL RESEARCH Risk of Hospitalization for Cardiovascular Events with b-Blockers in Hypertensive Patients: A Retrospective Cohort Study . . . . Jan Basile Brent Egan Henry Punzi Sanjida Ali . . Qian Li Mehul Patel Joel Neutel Received: April 27, 2018 / Published online: September 6, 2018 The Author(s) 2018 to unfavorable long-term cardiovascular events ABSTRACT observed with non-vasodilatory b-blockers. However, the comparative cardiovascular event Introduction: b-Blockers are a heterogenous risk between the vasodilatory b -selective class of drugs that are no longer recommended antagonist/b agonist nebivolol and non-va- for initial antihypertension monotherapy due sodilatory b -blockers, atenolol and metoprolol, is unknown. Enhanced digital features To view enhanced digital Methods: Incident nebivolol, atenolol, or features for this article go to https://doi.org/10.6084/ m9.figshare.6965000. metoprolol monotherapy users with hyperten- sion were identified using US claims data Electronic supplementary material The online (2007–2014). The first b-blocker claim on/after version of this article (https://doi.org/10.1007/s40119- 018-0117-y) contains supplementary material, which is 1/1/2008 defined the index drug/date. Hyper- available to authorized users. tensive patients without pre-index cardiovas- cular history were followed until index drug J. Basile (&) discontinuation ([ 90 day supply gap), use of Medical University of South Carolina,
Cardiology and Therapy – Springer Journals
Published: Sep 6, 2018
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