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Fukutomi et al. Clinical and Translational Allergy 2011, 1(Suppl 1):P49 http://www.ctajournal.com/content/1/S1/P49 POSTER PRESENTATION Open Access Rhinoconjunctival sensitization to hydrolyzed wheat protein in facial soap and induce wheat- dependant exercise-induced anaphylaxis 1* 2 1 1 1 1 Yuma Fukutomi , Yasuharu Itagaki , Masami Taniguchi , Akemi Saito , Hiroshi Yasueda , Takuya Nakazawa , 1 3 4 Maki Hasegawa , Hiroyuki Nakamura , Kazuo Akiyama From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy. 17-19 February 2011 Background eyelids or face after using the soap. Their symptoms of Wheat protein is responsible for various kinds of allergic allergy to facial soap resembled prodromal symptoms disease. Wheat-dependent exercise-induced anaphylaxis that develop following the combination of wheat inges- (WDEIA) is one of the most important clinical pheno- tion and exercise. A significantly higher IgE reactivity to types of adult wheat allergy. Relatively homogenous clin- HWP than to natural wheat protein was observed in ical and immunological presentations of this phenotype these patients. Inhibition analyses of their sera showed have already been described. More recently, some stu- that IgE reactivity to HWP was not inhibited by natural dies have shown that sensitization to hydrolyzed wheat wheat extracts, whereas those to natural wheat extracts protein (HWP) in cosmetics can induce allergy to were fully inhibited by HWP, indicating that the primary HWP-containing food as well as contact allergy to sensitizer of these patients is HWP. HWP-containing cosmetics. Discussion Case reports Ourreportisimportant inthatitindicates thepossible We experienced treating five Japanese women with role of HWP included in cosmetics in the induction of WDEIA with atypical presentation. They presented exer- allergy to natural wheat products. cise-induced anaphylaxis after ingestion of normal wheat products, but also had episodes of skin and/or rhinocon- Author details junctival contact allergy to hydrolyzed wheat protein 1 Sagamihara National Hospital, Clinical Research Center for Allergy and (HWP)-containing facial soap. Furthermore, case his- Rheumatology, Sagamihara Kanagawa, Japan. Hokkaido Bunkyo University, Department of Health and Nutrition, Faculty of Human Science, Eniwa, tories and serological analyses of these patients indicated Japan. Graduate School of Medical Science, Kanazawa University, Kanazawa that the development of their WDEIA was induced by Ishikawa, Japan. Sagamihara National Hospital, Sagamihara, Clinical Research primary sensitization to HWP in the facial soap they Center for Allergy and Rheumatology, Sagamihara Kanagawa, Japan. used and accompanying sensitization to natural wheat Published: 12 August 2011 protein. Methods and results doi:10.1186/2045-7022-1-S1-P49 All of the patients had started to use the same facial Cite this article as: Fukutomi et al.: Rhinoconjunctival sensitization to soap product containing HWP 1 to 3 years prior to the hydrolyzed wheat protein in facial soap and induce wheat-dependant exercise-induced anaphylaxis. Clinical and Translational Allergy 2011 1 onset of WDEIA. At first, they used the facial soap with- (Suppl 1):P49. out any problem. When they continued to use the soap, they started to experience itchiness and urticaria of the Sagamihara National Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara Kanagawa, Japan Full list of author information is available at the end of the article © 2011 Fukutomi et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical and Translational Allergy – Springer Journals
Published: Aug 12, 2011
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