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Retroperitoneal Sarcoma. Outcome Analysis in a Teaching Hospital in Eastern India- a Perspective

Retroperitoneal Sarcoma. Outcome Analysis in a Teaching Hospital in Eastern India- a Perspective Abstract Primary Retroperitoneal Sarcomas are relatively uncommon tumors with varied manifestations, ill-defined prognostic factors and uncertain management modalities. We undertook this study to review patients who presented with primary or recurrent RPS at our institute during the study period. Between 2008 and 2010, 23 patients were evaluated. Statistical analysis was done using the chi square test or Fisher’s exact test. Recurrence was calculated using Kaplan Meier curves. The log-rank test was used to compare differences in survival or relapse. Among the 23 patients, 13 were males. Majority (52.2 %) presented with abdominal lump located in umbilical and right hypochondrial region. Surgery was done in 20 (87 %) patients for primary RPS and three (13 %) for recurrent RPS at initial presentation. 14 (61 %) received complete tumor resection, six (27 %) incomplete microscopic resection, and three (13 %) incomplete macroscopic resection. In univariate Cox’s proportional hazard model on time (‘timer’) to event (‘relapse’) analysis, all the variables like older age (p = 0.027), male sex (p = 0.012), incomplete resection (p = 0.008), large size (0.047) and high grade (p = 0.047) became significant predictor of early recurrence. However, multivariate analysis showed that only extent of resection, grade and sex were statistically significant predictors. Complete tumor resection of retroperitoneal sarcoma (n = 14) was associated with a significantly lesser recurrence compared with unclear resection (n = 9, p = 0.002). The median time between surgery and first recurrence was 15 months. High-grade sarcomas had a significantly higher recurrence (n = 10; median: 24, 95 % CI) than low-grade sarcomas (n = 13, median: 15; 95 %CI P < 0.01). Furthermore, the survival of male patients were worse than that of females (p = 0.036). Completeness of resection, tumor grade and sex are prognostic factors of retroperitoneal soft tissue sarcomas. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Surgical Oncology Springer Journals

Retroperitoneal Sarcoma. Outcome Analysis in a Teaching Hospital in Eastern India- a Perspective

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Publisher
Springer Journals
Copyright
2015 Indian Association of Surgical Oncology
ISSN
0975-7651
eISSN
0976-6952
DOI
10.1007/s13193-015-0404-1
Publisher site
See Article on Publisher Site

Abstract

Abstract Primary Retroperitoneal Sarcomas are relatively uncommon tumors with varied manifestations, ill-defined prognostic factors and uncertain management modalities. We undertook this study to review patients who presented with primary or recurrent RPS at our institute during the study period. Between 2008 and 2010, 23 patients were evaluated. Statistical analysis was done using the chi square test or Fisher’s exact test. Recurrence was calculated using Kaplan Meier curves. The log-rank test was used to compare differences in survival or relapse. Among the 23 patients, 13 were males. Majority (52.2 %) presented with abdominal lump located in umbilical and right hypochondrial region. Surgery was done in 20 (87 %) patients for primary RPS and three (13 %) for recurrent RPS at initial presentation. 14 (61 %) received complete tumor resection, six (27 %) incomplete microscopic resection, and three (13 %) incomplete macroscopic resection. In univariate Cox’s proportional hazard model on time (‘timer’) to event (‘relapse’) analysis, all the variables like older age (p = 0.027), male sex (p = 0.012), incomplete resection (p = 0.008), large size (0.047) and high grade (p = 0.047) became significant predictor of early recurrence. However, multivariate analysis showed that only extent of resection, grade and sex were statistically significant predictors. Complete tumor resection of retroperitoneal sarcoma (n = 14) was associated with a significantly lesser recurrence compared with unclear resection (n = 9, p = 0.002). The median time between surgery and first recurrence was 15 months. High-grade sarcomas had a significantly higher recurrence (n = 10; median: 24, 95 % CI) than low-grade sarcomas (n = 13, median: 15; 95 %CI P < 0.01). Furthermore, the survival of male patients were worse than that of females (p = 0.036). Completeness of resection, tumor grade and sex are prognostic factors of retroperitoneal soft tissue sarcomas.

Journal

Indian Journal of Surgical Oncology – Springer Journals

Published: Jun 1, 2015

Keywords: surgical oncology; oncology; surgery

References

  • Diagnosis and management of retroperitoneal soft-tissue sarcoma
    FK Storm, D Mahvi
  • Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system
    H Nathan, CP Raut, K Thornton, JM Herman, N Ahuja, RD Schulick
  • Retroperitoneal sarcomas - a retrospective study
    M Al-Qahtani, A Asiri
  • Effect of resection and outcome in patients with retroperitoneal sarcoma
    A Chiappa, AP Zbar, R Bifffi, E Bertani, F Biella, G Viale
  • Operative management of primary retroperitoneal sarcomas: a reappraisal of an institutional experience
    I Hassan, SZ Park, JH Donohue, DM Nagorney, PA Kay, AG Nasciemento
  • prov-results/prov_data_products_wb
    http
  • Sarcoma
    KM Skubitz, DR D’Adamo
  • Clinical practice guidelines.Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
  • Role of chemotherapy in the management of soft tissue sarcomas
    D Krikelis, I Judson
  • Long-term outcomes after radiotherapy for retroperitoneal and deep truncal sarcoma
    M Feng, J Murphy, KA Griffith
  • Primary retroperitoneal sarcomas: common symptoms, common diagnoses, uncommon disease
    BH Ziran, JT Makley, JR Carter
  • Retroperitoneal and visceral sarcomas: issues for the general surgeon
    C Woodall, R Scoggins
  • Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management
    MJ Heslin, JJ Lewis, E Nadler, E Newman, JM Woodruff, ES Casper
  • Surgical management of primary and recurrent retroperitoneal liposarcoma
    SJ Neuhaus, P Barry, MA Clark, AJ Hayes, C Fisher, JM Thomas
  • Retroperitoneal sarcomas: grade and survival
    T Ferrario, CP Karakousis
  • AJCC cancer staging manual
    ID Fleming
  • High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas
    KM Alektiar, K Hu, L Anderson, MF Brennan, LB Harrison
  • Surgery and radiotherapy for retroperitoneal and abdominal sarcoma, both necessary and sufficient
    Z Zhou, TP McDade, JP Simons, SC Ng, LA Lambert, GF Whalen
  • Adjuvant chemo- therapy for localized respectable soft-tissue sarcoma of adults: meta-analysis of individual data
  • Is there a role for incomplete resection in the management of retroperitoneal Iiposarcomas?
    D Shibata, JJ Lewis, DH Leung, MF Brennan
  • Prognostic factors predictive of survival for truncal and retroperitoneal soft-tissue sarcoma
    S Singer, JM Corson, GD Demetri
  • Retroperitoneal soft-tissue sarcoma
    J Lewis, D Leung, J Woodruff
  • Li H Prognostic factors of retroperitoneal soft tissue sarcomas: analysis of 132 cases
    C Chen, L Yin, C Peng, Y Cai, Y Li, R Zhao, H Zhou
  • Major vascular resection and prosthetic replacement for retroperitoneal tumors
    P Fueglistaler, L Gurke, P Stierli, T Obeid, C Koella, D Oertli
  • Venous reconstruction of the inferior vena cava bifurcation for retroperitoneal rhabdomyosarcoma in a child. Case report
    V Chervenkoff, K Kirilova, AL Tschirkov
  • Preliminary results of a randomized study of adjuvant radiation therapy in resectable adult retroperitoneal soft tissue sarcomas
    TJ Kinsella, WF Sindelar, E Lack
  • Locoregional recurrence after preoperative radiation therapy for retroperitoneal sarcoma
    SM McBride, PC Raut, M Lapidus, MP Devlin, KJ Marcus, M Bertagnolli
  • Resectability of retroperitoneal sarcomas: a matter of surgical technique?
    CP Karakousis, K Kontzoglou, DL Driscoll
  • Retroperitoneal sarcomas: a reappraisal of treatment
    FK Storm, FR Eilber, J Mirra, DL Morton