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Response to major peanut and peach allergens in a population of children allergic to peanut

Response to major peanut and peach allergens in a population of children allergic to peanut Garcia-Blanca et al. Clinical and Translational Allergy 2015, 5(Suppl 3):P128 http://www.ctajournal.com/content/5/S3/P128 POSTER PRESENTATION Open Access Response to major peanut and peach allergens in a population of children allergic to peanut 1 2 1 1 1 3 Alexandra Garcia-Blanca , Ana Aranda , Natalia Blanca-Lopez , Diana Perez , Maria Luisa Somoza , Francisca Gomez , 4 3 5 3 1 3* Cristobalina Mayorga , Maria Jose Torres , Araceli Diaz Perales ,Miguel Blanca , Gabriela Canto , Gador Bogas From Food Allergy and Anaphylaxis Meeting 2014 Dublin, Ireland. 9-11 October 2014 Introduction both groups IgE response to the allergens was found, Specific IgE to food allergens may vary according to geo- with predominance of Arah2 in group A and Arah9 graphic areas due to differences in dietary habits, environ- (p=0.001) and Prup3 (p=0.008) in group B. In the differ- mental pollen exposure and other factors. Studies of the ent age groups observed a decrease in sensitisation to different patterns of sensitization, the relation with others Arah2 with an increase to Arah9 and Prup3 correlated allergens, clinical entities and variation according to age with age. are needed. We studied sensitization to Arah2, Arah9 and Prup3 in a population of children and adolescents from 1 Conclusions to 20 years, who were allergic to peanut and the relation- Peanut allergy is frequent in subjects with allergy of ship with peach allergy. vegetal origin. Arah2 and Arah9 were the most relevant proteins. Arah2 predominated over Arah9 in younger Methods patients. The reverse was observed in older patients. Patients allergic to peanut were chosen from a large num- A strong association was found between IgE response to ber of patients with allergy to plant-foods. They were clas- Arah9 and to Prup3. sified in: A) those allergic to peanut with tolerance to peach and B) those allergic to peach and peanut. The IgE Authors’ details response was measured by ImmunoCAP to Arah2, Arah9 1 2 Allergy Service, Infanta Leonor Hospital, Madrid, Spain. Research Laboratory, and Prup3 and the relationship with the different clinical IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain. Allergy Service, Carlos Haya Hospital, Malaga, Spain. Research Laboratory, Carlos entities as well as the variation according to age was Haya Hospital-FIMABIS, Malaga, Spain. Centre for Plant Biotechnology and analyzed. Genomic, Polytechnical University of Madrid, Madrid, Spain. Published: 30 March 2015 Results From a total of 348 subjects evaluated, 28% were allergic to peanut. The median age was 10.48 years and 69% had doi:10.1186/2045-7022-5-S3-P128 sensitization to pollens, with Phleum, Olea, Platanus Cite this article as: Garcia-Blanca et al.: Response to major peanut and and Artemisia the most relevant. Urticaria appeared in peach allergens in a population of children allergic to peanut. Clinical 47%, followed by anaphylaxis (27%) and oral allergy syn- and Translational Allergy 2015 5(Suppl 3):P128. drome (23%). A positive response to Arah2 and/or Arah9 appeared in the 59% of cases. The 54% reported symptoms with peanut and tolerance to peach (Group A) and 46% to peanut and peach (Group B). We observed significant differences in sex (p=0.02), age (p=0.01) and the sensitization to Artemisia (p=0.03). In Allergy Service, Carlos Haya Hospital, Malaga, Spain Full list of author information is available at the end of the article © 2015 Garcia-Blanca et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Allergy Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Garcia-Blanca et al; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
2045-7022
DOI
10.1186/2045-7022-5-S3-P128
Publisher site
See Article on Publisher Site

Abstract

Garcia-Blanca et al. Clinical and Translational Allergy 2015, 5(Suppl 3):P128 http://www.ctajournal.com/content/5/S3/P128 POSTER PRESENTATION Open Access Response to major peanut and peach allergens in a population of children allergic to peanut 1 2 1 1 1 3 Alexandra Garcia-Blanca , Ana Aranda , Natalia Blanca-Lopez , Diana Perez , Maria Luisa Somoza , Francisca Gomez , 4 3 5 3 1 3* Cristobalina Mayorga , Maria Jose Torres , Araceli Diaz Perales ,Miguel Blanca , Gabriela Canto , Gador Bogas From Food Allergy and Anaphylaxis Meeting 2014 Dublin, Ireland. 9-11 October 2014 Introduction both groups IgE response to the allergens was found, Specific IgE to food allergens may vary according to geo- with predominance of Arah2 in group A and Arah9 graphic areas due to differences in dietary habits, environ- (p=0.001) and Prup3 (p=0.008) in group B. In the differ- mental pollen exposure and other factors. Studies of the ent age groups observed a decrease in sensitisation to different patterns of sensitization, the relation with others Arah2 with an increase to Arah9 and Prup3 correlated allergens, clinical entities and variation according to age with age. are needed. We studied sensitization to Arah2, Arah9 and Prup3 in a population of children and adolescents from 1 Conclusions to 20 years, who were allergic to peanut and the relation- Peanut allergy is frequent in subjects with allergy of ship with peach allergy. vegetal origin. Arah2 and Arah9 were the most relevant proteins. Arah2 predominated over Arah9 in younger Methods patients. The reverse was observed in older patients. Patients allergic to peanut were chosen from a large num- A strong association was found between IgE response to ber of patients with allergy to plant-foods. They were clas- Arah9 and to Prup3. sified in: A) those allergic to peanut with tolerance to peach and B) those allergic to peach and peanut. The IgE Authors’ details response was measured by ImmunoCAP to Arah2, Arah9 1 2 Allergy Service, Infanta Leonor Hospital, Madrid, Spain. Research Laboratory, and Prup3 and the relationship with the different clinical IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain. Allergy Service, Carlos Haya Hospital, Malaga, Spain. Research Laboratory, Carlos entities as well as the variation according to age was Haya Hospital-FIMABIS, Malaga, Spain. Centre for Plant Biotechnology and analyzed. Genomic, Polytechnical University of Madrid, Madrid, Spain. Published: 30 March 2015 Results From a total of 348 subjects evaluated, 28% were allergic to peanut. The median age was 10.48 years and 69% had doi:10.1186/2045-7022-5-S3-P128 sensitization to pollens, with Phleum, Olea, Platanus Cite this article as: Garcia-Blanca et al.: Response to major peanut and and Artemisia the most relevant. Urticaria appeared in peach allergens in a population of children allergic to peanut. Clinical 47%, followed by anaphylaxis (27%) and oral allergy syn- and Translational Allergy 2015 5(Suppl 3):P128. drome (23%). A positive response to Arah2 and/or Arah9 appeared in the 59% of cases. The 54% reported symptoms with peanut and tolerance to peach (Group A) and 46% to peanut and peach (Group B). We observed significant differences in sex (p=0.02), age (p=0.01) and the sensitization to Artemisia (p=0.03). In Allergy Service, Carlos Haya Hospital, Malaga, Spain Full list of author information is available at the end of the article © 2015 Garcia-Blanca et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Journal

Clinical and Translational AllergySpringer Journals

Published: Mar 30, 2015

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