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Curr Allergy Asthma Rep (2017) 17: 75 DOI 10.1007/s11882-017-0743-9 LETTER TO THE EDITOR Response to Ebo et al., Letter to the Editor Regarding Update on Quinolone Allergy 1 2,3 1 4 Inmaculada Doña & Esther Moreno & Natalia Pérez-Sánchez & Inmaculada Andreu & 5 1 Dolores Hernández Fernandez de Rojas & María José Torres Published online: 4 October 2017 Springer Science+Business Media, LLC 2017 Dear Editor in Chief: (MRGPRX2)-inducing mast cell activation and degranulation We thank Van Gasse et al. for their correspondence and for directly by quinolones will help to elucidate these particular raising the question of non-IgE mechanisms of mast cell acti- issues concerning quinolone hypersensitivity reactions. vation in hypersensitivity reactions to quinolones [1]. This in- However, skin tests have been shown to give a sensitivity teresting paper unfortunately could not be included in our re- of up to 71% and a specificity of up to 86%, with positive and view due to its recent publication. Anaphylactic reactions in- negative predictive values of up to 50 and 94%, respectively duced by drugs through a non-IgE-mediated mechanism have [11], suggesting that a specific IgE mechanism might explain been reported and include complement-mediated or direct acti- a high proportion
Current Allergy and Asthma Reports – Springer Journals
Published: Oct 1, 2017
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