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Reductive aminations using a 3D printed supported metal(0) catalyst system

Reductive aminations using a 3D printed supported metal(0) catalyst system Abstract Additively manufactured catalytic static mixers were used for the intensified reductive amination of aldehydes and ketones inside a continuous flow reactor. This efficient synthesis method is enabled by the use of tubular reactors fitted with 3D printed metal static mixers which are coated with a catalytically active layer, either Pd or Ni. The 3D printing process allows for maximum design flexibility for the mixer scaffold and is compatible with a range of deposition methods including electroplating and metal cold spraying. Single- and multi-stage continuous flow processing yielded high to full conversion and has the potential to scale-up these operations without the need for manual handling of reactive imine intermediates. The continuous flow reductive amination was performed in a tubular hydrogenation reactor, using nickel or palladium containing catalytic static mixers Graphical Abstract http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Reductive aminations using a 3D printed supported metal(0) catalyst system

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Publisher
Springer Journals
Copyright
2018 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-018-0013-6
Publisher site
See Article on Publisher Site

Abstract

Abstract Additively manufactured catalytic static mixers were used for the intensified reductive amination of aldehydes and ketones inside a continuous flow reactor. This efficient synthesis method is enabled by the use of tubular reactors fitted with 3D printed metal static mixers which are coated with a catalytically active layer, either Pd or Ni. The 3D printing process allows for maximum design flexibility for the mixer scaffold and is compatible with a range of deposition methods including electroplating and metal cold spraying. Single- and multi-stage continuous flow processing yielded high to full conversion and has the potential to scale-up these operations without the need for manual handling of reactive imine intermediates. The continuous flow reductive amination was performed in a tubular hydrogenation reactor, using nickel or palladium containing catalytic static mixers Graphical Abstract

Journal

Journal of Flow ChemistrySpringer Journals

Published: Jun 1, 2018

References