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Oncol Ther (2019) 7:67–81 https://doi.org/10.1007/s40487-019-0094-x ORIGINAL RESEARCH Real-World Impact of Physician and Patient Discordance on Health-Related Quality of Life in US Patients with Acute Myeloid Leukemia . . . . L. Elise Horvath Walsh Alex Rider James Piercy James Pike . . Samuel Wilson Bhavik J. Pandya Bruno C. Medeiros Received: January 16, 2019 / Published online: April 26, 2019 The Author(s) 2019 Methods: Physicians in the USA captured ABSTRACT demographics, current AML treatment and symptoms for 82 AML patients who completed Introduction: There is limited understanding the Functional Assessment of Cancer Therapy- concerning the health-related quality of life Leukemia (FACT-Leu), 5-Dimension EuroQol (HRQoL) in acute myeloid leukemia (AML) Questionnaire (EQ-5D-3L) and Cancer Treat- patients. Due to an overlap of symptoms, it can ment Satisfaction Questionnaire (CTSQ). Effect be difficult to separate disease versus treatment- size (ES) and clinically meaningful differences related effects. Study objectives were to under- between AML subgroups were assessed, as was stand the impact of factors that might influence the impact of disagreement between patients patients’ HRQoL, assess the degree of concor- and physicians regarding symptom recognition. dance in symptom reporting by patients and Results: Clinically meaningful lower overall physicians, and assess the impact of
Oncology and Therapy – Springer Journals
Published: Apr 26, 2019
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