Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Real-time oxidative stress biomarkers measured in patients with Hashimoto’s thyroiditis—an electron paramagnetic resonance study

Real-time oxidative stress biomarkers measured in patients with Hashimoto’s thyroiditis—an... Although the role of presence of thyroid dysfunction for overproduction of free radicals has been elucidated, the data about the role of autoimmunity in Hashimoto’s thyroiditis (HT) to sustain the presence of oxidative stress despite the normal serum thyroid hormone levels are scarce. The present study aimed by using electron paramagnetic resonance spectroscopy (EPR) methods to elucidate the radical mechanisms included in the pathogenesis of HT by following out the sera levels of some Breal-time^ oxidative stress biomarkers. We investigated 14 newly diagnosed patients with euthyroid HT and 35 subjects with HT treated with levothyroxine. Twenty-three healthy subjects were included as controls. All samples were measured in triplicate and presented as arbitrary units. We found statistically significant elevated levels of ascorbate radical (Asc� ) in euthyroid HT patients and in HT patients treated with levothyroxine compared to controls. Reactive oxygen species (ROS) products were statistically higher in both studied patient groups compared to controls. Our study showed also statistically significant increases in the levels of registered nitric oxide radical (NO� ) in both groups of HT patients compared to controls. Oxidative stress is increased similarly in both euthyroid HT and HT patients under treatment with LT4 and these data http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Real-time oxidative stress biomarkers measured in patients with Hashimoto’s thyroiditis—an electron paramagnetic resonance study

Loading next page...
 
/lp/springer-journals/real-time-oxidative-stress-biomarkers-measured-in-patients-with-rSr1P5Av06

References (34)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer-Verlag London Ltd., part of Springer Nature
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-019-02943-w
Publisher site
See Article on Publisher Site

Abstract

Although the role of presence of thyroid dysfunction for overproduction of free radicals has been elucidated, the data about the role of autoimmunity in Hashimoto’s thyroiditis (HT) to sustain the presence of oxidative stress despite the normal serum thyroid hormone levels are scarce. The present study aimed by using electron paramagnetic resonance spectroscopy (EPR) methods to elucidate the radical mechanisms included in the pathogenesis of HT by following out the sera levels of some Breal-time^ oxidative stress biomarkers. We investigated 14 newly diagnosed patients with euthyroid HT and 35 subjects with HT treated with levothyroxine. Twenty-three healthy subjects were included as controls. All samples were measured in triplicate and presented as arbitrary units. We found statistically significant elevated levels of ascorbate radical (Asc� ) in euthyroid HT patients and in HT patients treated with levothyroxine compared to controls. Reactive oxygen species (ROS) products were statistically higher in both studied patient groups compared to controls. Our study showed also statistically significant increases in the levels of registered nitric oxide radical (NO� ) in both groups of HT patients compared to controls. Oxidative stress is increased similarly in both euthyroid HT and HT patients under treatment with LT4 and these data

Journal

Comparative Clinical PathologySpringer Journals

Published: Mar 25, 2019

There are no references for this article.