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Rational design of nano- and micro-size medicinal forms of biologically active substances

Rational design of nano- and micro-size medicinal forms of biologically active substances In the review, the properties of nano- and microparticles as tools for delivery of medicinal substances (namely, size, shape, and superfacial characteristics) are discussed. The main fields of application of these particles, such as therapy of malignant tumors and intracellular infections, increase in vaccine adjuvanticity, solubilization of poorly soluble compounds, and delivery to the brain, are discussed. Effects provided by substance loading into nano- and microparticles (reduced toxicity, protection from rapid degradation, and deposition) are described. The most progress is expected in active targeting, intracellular targeting, and controllable release. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Rational design of nano- and micro-size medicinal forms of biologically active substances

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References (62)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Medical Microbiology; Biochemistry, general; Microbiology
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683811080072
Publisher site
See Article on Publisher Site

Abstract

In the review, the properties of nano- and microparticles as tools for delivery of medicinal substances (namely, size, shape, and superfacial characteristics) are discussed. The main fields of application of these particles, such as therapy of malignant tumors and intracellular infections, increase in vaccine adjuvanticity, solubilization of poorly soluble compounds, and delivery to the brain, are discussed. Effects provided by substance loading into nano- and microparticles (reduced toxicity, protection from rapid degradation, and deposition) are described. The most progress is expected in active targeting, intracellular targeting, and controllable release.

Journal

Applied Biochemistry and MicrobiologySpringer Journals

Published: Nov 6, 2011

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