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In the review, the properties of nano- and microparticles as tools for delivery of medicinal substances (namely, size, shape, and superfacial characteristics) are discussed. The main fields of application of these particles, such as therapy of malignant tumors and intracellular infections, increase in vaccine adjuvanticity, solubilization of poorly soluble compounds, and delivery to the brain, are discussed. Effects provided by substance loading into nano- and microparticles (reduced toxicity, protection from rapid degradation, and deposition) are described. The most progress is expected in active targeting, intracellular targeting, and controllable release.
Applied Biochemistry and Microbiology – Springer Journals
Published: Nov 6, 2011
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