Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/protein-chip-based-glp-1-receptor-assay-system-UiTVW2DVuF
References (20)
-
Jung-kyu Lee, I. Kang (2013)
Analysis of Plk1-Bora interaction using a protein chip systemBioChip Journal, 7
-
Chan-Won Park, I. Kang, Youngjin Choi (2012)
Activity-based screening system for the discovery of neuraminidase inhibitors using protein chip technologyBioChip Journal, 6
-
J. Buse, D. Klonoff, L. Nielsen, X. Guan, C. Bowlus, J. Holcombe, D. Maggs, M. Wintle (2007)
Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials.Clinical therapeutics, 29 1
-
K. Murphy, S. Bloom (2007)
Nonpeptidic glucagon-like peptide 1 receptor agonists: A magic bullet for diabetes?Proceedings of the National Academy of Sciences, 104
-
A. Ling, Y. Hong, J. González, V. Gregor, A. Polinsky, A. Kuki, S. Shi, K. Teston, D. Murphy, J. Porter, D. Kiel, J. Lakis, K. Anderes, J. May, L. Knudsen, J. Lau (2001)
Identification of alkylidene hydrazides as glucagon receptor antagonists.Journal of medicinal chemistry, 44 19
-
J. Bang, Eung-Yoon Kim, T. Shim, Hwa-Seung Yoo, Yeon-weol Lee, Yong-Soo Kim, C. Cho, Yong-seok Choi, Hyun‐Ja Jeong, I. Kang (2010)
Analysis of anti-angiogenic mechanism of HangAmDan-B (HAD-B), a Korean traditional medicine, using antibody microarray chipBioChip Journal, 4
-
(2009)
Analysis of Antigen - antibody Interactions Using Combination of Protein Nanoarray and Atomic Force Measurement -
J. Bang, Eung-Yoon Kim, Dongku Kang, Soo‐Ik Chang, M. Han, K. Baek, I. Kang (2011)
Pharmacoproteomic Analysis of a Novel Cell-permeable Peptide Inhibitor of Tumor-induced Angiogenesis*Molecular & Cellular Proteomics, 10
-
Chan-Won Park, J. Bang, Youngjin Choi, I. Kang (2011)
ProteoChip-based screening system of novel inhibitors against the interaction of VEGF165 and β-Amyloid1–42BioChip Journal, 5
-
H. Su, Min He, Hongmei Li, Qing Liu, Jia Wang, Yiqian Wang, Wei-wei Gao, Ling Zhou, Jia-yu Liao, A. Young, Ming-Wei Wang (2008)
Boc5, a Non-Peptidic Glucagon-Like Peptide-1 Receptor Agonist, Invokes Sustained Glycemic Control and Weight Loss in Diabetic MicePLoS ONE, 3
-
H. Doods, G. Hallermayer, Dongmei Wu, M. Entzeroth, K. Rudolf, W. Engel, W. Eberlein (2000)
Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonistBritish Journal of Pharmacology, 129
-
(2007)
3 . 5 years of exenatide maintained progressive weight reduction was associated with improvements in cardiovascular risk factors in patients with type 2 diabetes ( T 2 DM ) -
Eung-Yoon Kim, Youngjin Choi, Chan-Won Park, I. Kang (2009)
Erkitinib, a novel EGFR tyrosine kinase inhibitor screened using a ProteoChip system from a phytochemical library.Biochemical and biophysical research communications, 389 3
-
김응윤, I. Kang (2009)
Protein Chip-based Dipeptidyl Peptidase IV Assay SystemBiochip Journal, 3
-
L. Knudsen, D. Kiel, M. Teng, C. Behrens, D. Bhumralkar, J. Kodra, J. Holst, C. Jeppesen, Michael Johnson, J. Jong, A. Jørgensen, T. Kercher, Jarek Kostrowicki, P. Madsen, P. Olesen, J. Petersen, F. Poulsen, U. Sidelmann, J. Sturis, L. Truesdale, J. May, J. Lau (2007)
Small-molecule agonists for the glucagon-like peptide 1 receptorProceedings of the National Academy of Sciences, 104
-
C. Chen, R. Dagnino, E. Souza, D. Grigoriadis, Charles Huang, Kyung-Il Kim, Zhengyu Liu, T. Moran, T. Webb, J. Whitten, Y. Xie, J. Mccarthy (1997)
Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor1 Receptor AntagonistsChemInform, 28
-
Youngjin Choi, Eung-Su Kim, Yoonsuk Lee, M. Han, I. Kang (2010)
Site‐specific inhibition of integrin αvβ3‐vitronectin association by a ser‐asp‐val sequence through an Arg‐Gly‐Asp‐binding site of the integrinPROTEOMICS, 10
-
Chan-Won Park, Min Kim, Youngjin Choi, I. Kang (2012)
Analysis of PKC β-mediated tyrosinase phosphorylation using ProteoChipBioChip Journal, 6
-
J. Bang, Kyungmin Kim, Eung-Yoon Kim, Hwa-Seung Yoo, Yeon-weol Lee, C. Cho, Youngjin Choi, Hyun‐Ja Jeong, I. Kang (2011)
Anti-angiogenic effects of the water extract of HangAmDan (WEHAD), a Korean traditional medicineScience China Life Sciences, 54
-
C. Chen (1996)
Design and synthesis of a series of nonpeptide high-affinity human corticotropin-releasing factor1 receptor antagonistsJ. Med. Chem., 39
- Publisher
- Springer Journals
- Copyright
- 2014 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg
- ISSN
- 1976-0280
- eISSN
- 2092-7843
- DOI
- 10.1007/s13206-014-8310-0
- Publisher site
- See Article on Publisher Site
Abstract
Abstract We investigated GLP-1 Receptor (GLP-1R) assay system on the basis of receptor-ligand interaction using ProteoChip. GLP-1R was immobilized on the surface of the ProteoChip and then GLP-1 peptide labeled with a Cy5-fluorescent dye was interacted with the GLP-1R array on the chip in a dose-dependent manner. Exendin-4 was tested for targeting GLP-1R to demonstrate the chip-based GLP-1R assay system. Chemical compound 6 and 45 were screened as novel agonists of GLP-1R using the GLP-1R assay system. The compound significantly inhibited GLP-1 binding to GLP-1R in a dose-dependent manner. The protein chip-based GLP-1R assay system will serve as a useful tool for screening of novel GLP-1R agonists.
Journal
BioChip Journal – Springer Journals
Published: Sep 1, 2014