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Prospects for the Use of Methylotrophic Yeast in the Creation of Industrial Producers of Feed Enzymes

Prospects for the Use of Methylotrophic Yeast in the Creation of Industrial Producers of Feed... In recent years, mycelial fungi have faced competition from recombinant yeast as producers of feed enzymes. An intensive study on genetic diversity identified the yeast genes encoding feed enzymes, the specific activity of which is much higher than that in mycelial fungi. In addition, these genes were expressed in yeast much more efficiently than in mycelial fungi. The use of yeast recombinant producers allowed the expansion of the production of a line of industrial enzymes with a significant reduction in their cost. The advantages of yeast producers of recombinant enzymes include the ability to obtain monoenzymes, which are part of various enzyme complexes used for different purposes. Pichia pastoris methylotrophic yeast is the most attractive subject for the creation of recombinant protein-producing strains. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Prospects for the Use of Methylotrophic Yeast in the Creation of Industrial Producers of Feed Enzymes

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References (55)

Publisher
Springer Journals
Copyright
Copyright © Pleiades Publishing, Inc. 2020. ISSN 0003-6838, Applied Biochemistry and Microbiology, 2020, Vol. 56, No. 8, pp. 815–821. © Pleiades Publishing, Inc., 2020. Russian Text © The Author(s), 2019, published in Biotekhnologiya, 2019, Vol. 35, No. 6, pp. 12–20.
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683820080050
Publisher site
See Article on Publisher Site

Abstract

In recent years, mycelial fungi have faced competition from recombinant yeast as producers of feed enzymes. An intensive study on genetic diversity identified the yeast genes encoding feed enzymes, the specific activity of which is much higher than that in mycelial fungi. In addition, these genes were expressed in yeast much more efficiently than in mycelial fungi. The use of yeast recombinant producers allowed the expansion of the production of a line of industrial enzymes with a significant reduction in their cost. The advantages of yeast producers of recombinant enzymes include the ability to obtain monoenzymes, which are part of various enzyme complexes used for different purposes. Pichia pastoris methylotrophic yeast is the most attractive subject for the creation of recombinant protein-producing strains.

Journal

Applied Biochemistry and MicrobiologySpringer Journals

Published: Dec 1, 2020

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