A large number of management options are available for treating basal cell carcinoma (BCC). While surgical resection is the gold standard treatment, novel approaches are constantly being developed and studied to treat tumors effectively and safely in a noninvasive way. A decade ago, several modalities such as immunotherapy and photodynamic therapy were considered investigational. Today, such drugs as imiquimod and porfimer sodium (Photofrin™) are being reported in the literature for treatment of selected BCCs. Some efforts have focused on increasing drug delivery or penetration into tumors with electrochemotherapy and cytotoxic agents. Other advances in drug therapy, such as chemoprevention with retinoids appear promising but may need further trials to gain acceptance. This review explores the potential of drug therapy for BCCs.
American Journal of Cancer – Springer Journals
Published: Aug 10, 2012
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