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Preparation of HA/β-TCP scaffold and mechanical strength optimization using a genetic algorithm method

Preparation of HA/β-TCP scaffold and mechanical strength optimization using a genetic algorithm... Calcium phosphate is widely used as bone scaffold because of its degradation and biocompatible properties. The scaffold must provide high surface area for cellular adhesion from biological surrounding, and suitable mechanical properties for the substitution of damaged bones. Also, the scaffold must be biocompatible, degradable, and the resorption controlled to match those of natural tissues. There are numerous procedures designed for the scaffold that depend on innovation and experiment. The scaffold was prepared by sacrificial method of mixing calcium phosphate powder with polymeric powder polyethylene glycol (PEG). Then, pressing in the cylindrical mold uniaxially, and porous structure of hydroxyapatite and β-tricalcium phosphate (HA/β-TCP) was obtained after sintering. Genetic algorithm optimization was used to optimize the compressive strength; the ratio of brushite and porosity were the parameters of problem. By maximizing the objective function genetic optimization showed that the best compressive strength was (54.67MPa) at 25 wt% ratio of brushite and 40% volume fraction of porosity and experimental value (53.3MPa).The slight difference between these values, perhaps attributable to uncontrolled conditions such as moisture, presence of agglomerate, and the morphology of porosity and other factors, could have led to this difference. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Australian Ceramic Society Springer Journals

Preparation of HA/β-TCP scaffold and mechanical strength optimization using a genetic algorithm method

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Australian Ceramic Society
Subject
Materials Science; Ceramics, Glass, Composites, Natural Materials; Materials Engineering; Inorganic Chemistry
ISSN
2510-1560
eISSN
2510-1579
DOI
10.1007/s41779-016-0007-5
Publisher site
See Article on Publisher Site

Abstract

Calcium phosphate is widely used as bone scaffold because of its degradation and biocompatible properties. The scaffold must provide high surface area for cellular adhesion from biological surrounding, and suitable mechanical properties for the substitution of damaged bones. Also, the scaffold must be biocompatible, degradable, and the resorption controlled to match those of natural tissues. There are numerous procedures designed for the scaffold that depend on innovation and experiment. The scaffold was prepared by sacrificial method of mixing calcium phosphate powder with polymeric powder polyethylene glycol (PEG). Then, pressing in the cylindrical mold uniaxially, and porous structure of hydroxyapatite and β-tricalcium phosphate (HA/β-TCP) was obtained after sintering. Genetic algorithm optimization was used to optimize the compressive strength; the ratio of brushite and porosity were the parameters of problem. By maximizing the objective function genetic optimization showed that the best compressive strength was (54.67MPa) at 25 wt% ratio of brushite and 40% volume fraction of porosity and experimental value (53.3MPa).The slight difference between these values, perhaps attributable to uncontrolled conditions such as moisture, presence of agglomerate, and the morphology of porosity and other factors, could have led to this difference.

Journal

Journal of the Australian Ceramic SocietySpringer Journals

Published: Jan 26, 2017

References