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Background: We aimed to enhance the solubility, dissolution properties, and skin-whitening ability of ferulic acid (FA) by preparing a ferulic acid–phospholipid complex (FA–PC). The properties and melanogenesis inhibition activities of FA–PC were then elucidated. Methods: We characterized the complex via differential scanning calorimetry, Fourier transform infrared spectros- copy, scanning electron microscopy, solubility, and oil–water partition coefficient. A Strat-M membrane, a synthetic membrane possessing diffusion characteristics that are well-correlated with human skin, was used for the diffusion studies of FA–PC. Results: We found that the lipophilicity of FA improved when complexed with phospholipids, allowing FA–PC to release FA in a controlled pattern. In the same time, complexing with phospholipids also obviously enhanced inhibi- tion of B16F10 cellular melanogenesis. Conclusions: FA–PC is a promising material for medicinal and cosmetic usages. Keywords: Ferulic acid, Phospholipid, Solubility, Transdermal permeation, Melanin inhibition Background and inflammation-associated enzymes [ 5] and matrix Ferulic acid (FA; 4-hydroxy-3-methoxycinnamic acid) metalloproteinases (MMPs), and attenuates the degrada- is present in many foods, including wheat, rice, barley, tion of collagen fibers [ 6]. oats, citrus fruits, and tomatoes [1]. FA has been shown Phospholipid complexes are widely used in the phar- to afford significant skin protection against UV-induced maceutical industry. They
Chemistry Central Journal – Springer Journals
Published: Mar 22, 2017
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