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References (22)
-
S. Unezaki, K. Maruyama, J. Hosoda, I. Nagae, Y. Koyanagi, M. Nakata, O. Ishida, M. Iwatsuru, S. Tsuchiya (1996)
Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopyInternational Journal of Pharmaceutics, 144
-
A. Chenite, M. Buschmann, D. Wang, C. Chaput, N. Kandani (2001)
Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutionsCarbohydrate Polymers, 46
-
M. Reist J. Berger (2004)
10.1016/S0939-6411(03)00161-9Eur. J. Pharm. Biopharm., 57
-
G. Molinaro, J. Leroux, J. Damas, A. Adam (2002)
Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials.Biomaterials, 23 13
-
A. Chenite, C. Chaput, D. Wang, C. Combes, M. Buschmann, C. Hoemann, J. Leroux, B. Atkinson, F. Binette, A. Selmani (2000)
Novel injectable neutral solutions of chitosan form biodegradable gels in situ.Biomaterials, 21 21
-
J. Berger, M. Reist, J. Mayer, O. Felt, R. Gurny (2004)
Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 57 1
-
M. Fujita, M. Ishihara, Masafumi Simizu, K. Obara, T. Ishizuka, Yoshio Saito, H. Yura, Y. Morimoto, B. Takase, T. Matsui, M. Kikuchi, T. Maehara (2004)
Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel.Biomaterials, 25 4
-
J. Berger, M. Reist, J. Mayer, O. Felt, N. Peppas, R. Gurny (2003)
Structure and Interactions in Covalently and Ionically Crosslinked Chitosan Hydrogels for Biomedical Applications -
Lie Ma, Changyou Gao, Z. Mao, Jie Zhou, Jia-cong Shen, Xueqing Hu, Chunmao Han (2003)
Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering.Biomaterials, 24 26
-
Eve Ruel-Gariépy, A. Chenite, C. Chaput, S. Guirguis, J. Leroux (2000)
Characterization of thermosensitive chitosan gels for the sustained delivery of drugs.International journal of pharmaceutics, 203 1-2
-
Anne Paavola, I. Kilpeläinen, J. Yliruusi, P. Rosenberg (2000)
Controlled release injectable liposomal gel of ibuprofen for epidural analgesia.International journal of pharmaceutics, 199 1
-
K. Tomihata, Y. Ikada (1997)
In vitro and in vivo degradation of films of chitin and its deacetylated derivatives.Biomaterials, 18 7
-
F. Mi, Yubing Tan, Hsiang-Fa Liang, Hsing‐Wen Sung (2002)
In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant.Biomaterials, 23 1
-
K. Kofuji, H. Akamine, Chun-Jun Qian, K. Watanabe, Y. Togan, M. Nishimura, I. Sugiyama, Y. Murata, S. Kawashima (2004)
Therapeutic efficacy of sustained drug release from chitosan gel on local inflammation.International journal of pharmaceutics, 272 1-2
-
Eve Ruel-Gariépy, Grégoire Leclair, P. Hildgen, A. Gupta, J. Leroux (2002)
Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules.Journal of controlled release : official journal of the Controlled Release Society, 82 2-3
-
J.-K. Suh, H. Matthew (2000)
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review.Biomaterials, 21 24
-
Sang Lee, Sung-Mi Seo, Youn-Mook Lim, S. Cho, Y. Lee, Y. Nho (2004)
Preparation of alginate/poly(N-isopropylacrylamide) hydrogels using gamma-ray irradiation graftingMacromolecular Research, 12
-
Haojie Zhao, Kai Wang, Yi Zhao, Li-qun Pan (2002)
Novel sustained-release implant of herb extract using chitosan.Biomaterials, 23 23
-
J. Lee, D. Lee, S. Kim (2003)
pH- and temperature-sensitive bifunctional hydrogels ofN-isopropylacrylamide and sulfadimethoxine monomerMacromolecular Research, 11
-
B. Jeong, Y. Bae, D. Lee, S. Kim (1997)
Biodegradable block copolymers as injectable drug-delivery systemsNature, 388
-
Haifeng Liu, J. Mao, K. Yao, Guanghui Yang, Lei Cui, Yilin Cao (2004)
A study on a chitosan-gelatin-hyaluronic acid scaffold as artificial skin in vitro and its tissue engineering applicationsJournal of Biomaterials Science, Polymer Edition, 15
-
Eve Ruel-Gariépy, M. Shive, A. Bichara, M. Berrada, D. Garrec, A. Chenite, J. Leroux (2004)
A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 57 1
- Publisher
- Springer Journals
- Copyright
- 2004 The Polymer Society of Korea and Springer
- ISSN
- 1598-5032
- eISSN
- 2092-7673
- DOI
- 10.1007/BF03218435
- Publisher site
- See Article on Publisher Site
Abstract
Abstract We have developed an injectable thermosensitive hydrogel for local drug delivery to treat cancers clinically. We selected chitosan as a polymer matrix because of its biocompatibility and biodegradability. Glycerol 2-phosphate disodium salt hydrate (β-GP) was used to neutralize the chitosan solution to physiological pH. The chitosan solution displayed a sol-gel phase transition in a pH- and temperature-dependent manner and formed an endothermic hydrogel after subcutaneous injection into mouse in the presence of β-GP. Additionally, we evaluated the biodegradation of chitosan hydrogel in mice by measuring the volume of injected chitosan hydrogel after subcutaneous injection. The injected chitosan hydrogel in mice was sected and stained with hematoxylin-eosin reagent for histological observation to confirm biodegradation of the hydrogel by the infiltrated cells. Chitosan hydrogel systems that possess biocompatibility and biodegradability could be promising thermosensitive injectable materials useful as depot systems for local anti-cancer drug delivery.
Journal
"Macromolecular Research" – Springer Journals
Published: Oct 1, 2004