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- Publisher
- Springer Journals
- Copyright
- Copyright © 2010 by Korean Society of Nuclear Medicine
- Subject
- Medicine & Public Health; Imaging / Radiology; Oncology; Orthopedics; Cardiology; Nuclear Medicine
- ISSN
- 1869-3474
- eISSN
- 1869-3482
- DOI
- 10.1007/s13139-010-0068-2
- pmid
- 24899987
- Publisher site
- See Article on Publisher Site
Abstract
Nucl Med Mol Imaging (2011) 45:93–102 DOI 10.1007/s13139-010-0068-2 ORIGINAL ARTICLE Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression Zhongxing Liang & Heidi T. Cho & Larry Williams & Aizhi Zhu & Ke Liang & Ke Huang & Hui Wu & Chunsu Jiang & Samuel Hong & Ronald Crowe & Mark M. Goodman & Hyunsuk Shim Received: 12 August 2010 /Accepted: 4 November 2010 /Published online: 24 November 2010 Korean Society of Nuclear Medicine 2010 Abstract PET tracer for the non-invasive imaging of malignant breast Purpose L-type amino acid transporter 1 (LAT1) is cancer using an orthotopic animal model. essential for the transport of large neutral amino acids. Conclusions The overexpression of LAT1 is required for However, its role in breast cancer growth remains largely the progression of breast cancer. LAT1 represents a unknown. The purpose of the study is to investigate potential biomarker for therapy and diagnosis of breast whether LAT1 is a potential biomarker for the diagnosis cancer. Anti-[ F]FACBC that correlates with LAT1 func- and treatment of breast cancer. tion is a potential PET tracer for malignant breast tumor Methods LAT1 mRNA and protein levels in breast cancer imaging. cell lines and tissues
Journal
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Nov 24, 2010