Access the full text.
Sign up today, get DeepDyve free for 14 days.
René Thomas (1998)
Laws for the dynamics of regulatory networks.The International journal of developmental biology, 42 3
H. Atlan (1999)
La fin du tout génétique? Vers de nouveaux paradigmes en biologic
J.W. Lengeler, I.G. Drews (1999)
Biology of the procaryotes
René Thomas, M. Kaufman (2001)
Multistationarity, the basis of cell differentiation and memory. II. Logical analysis of regulatory networks in terms of feedback circuits.Chaos, 11 1
H. Atlan (1999)
La Fin du "tout génétique"? : vers de nouveaux paradigmes en biologie : une conférence-débat organisée par le groupe Sciences en questions, Paris, INRA, 28 mai 1998
M. Cohn, K. Horibata (1959)
PHYSIOLOGY OF THE INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLIJournal of Bacteriology, 78
René Thomas, D. Thieffry, M. Kaufman (1995)
Dynamical behaviour of biological regulatory networks--I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state.Bulletin of mathematical biology, 57 2
P. Montfort, B. Baleux (1999)
Bactéries viables non cultivables: réalité et conséquencesBulletin de la société française de microbiologie, 14
P. Schaeffer, J. Millet, J. Aubert (1965)
Catabolic repression of bacterial sporulation.Proceedings of the National Academy of Sciences of the United States of America, 54 3
M. Cohn, K. Horibata (1959)
INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI. ANALYSIS OF MAINTENANCEJournal of Bacteriology, 78
R Thomas, R. D'Ari (1990)
Biological feedback
J. Demongeot, M. Kaufman, R. Thomas (2000)
Positive feedback circuits and memory.Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 323 1
R. Thomas, P. Ham (1975)
Analyse formelle de circuits de régulation génétique: le contrôle de l’immunité chez les bactériophages lambdoïdesBiochimie, 56
D. Thieffry, René Thomas (1995)
Dynamical behaviour of biological regulatory networks--II. Immunity control in bacteriophage lambda.Bulletin of mathematical biology, 57 2
René Thomas (1991)
Regulatory networks seen as asynchronous automata: A logical descriptionJournal of Theoretical Biology, 153
J. Govan, G. Harris (1986)
Pseudomonas aeruginosa and cystic fibrosis: unusual bacterial adaptation and pathogenesis.Microbiological sciences, 3 10
M. Schurr, D. Martin, M. Mudd, V. Deretic (1994)
Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidyJournal of Bacteriology, 176
René Thomas (1973)
Boolean formalization of genetic control circuits.Journal of theoretical biology, 42 3
A. Novick, Milton Weiner (1957)
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON.Proceedings of the National Academy of Sciences of the United States of America, 43 7
El Snoussi (1989)
Qualitative dynamics of piecewise-linear differential equations: a discrete mapping approachDynamics and Stability of Systems, 4
René Thomas, M. Kaufman (2001)
Multistationarity, the basis of cell differentiation and memory. I. Structural conditions of multistationarity and other nontrivial behavior.Chaos, 11 1
A. Danchin (1999)
L'habit ne fait pas le moineLa Recherche, 326
H. Snoussi, René Thomas (1993)
Logical identification of all steady states: The concept of feedback loop characteristic statesBulletin of Mathematical Biology, 55
M. Cohn, K. Horibata (1959)
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESISJournal of Bacteriology, 78
René Thomas (1979)
Kinetic logic : a Boolean approach to the analysis of complex regulatory systems : proceedings of the EMBO course "Formal analysis of genetic regulation," held in Brussels, September 6-16, 1977
The mechanisms by which bacteria adapt to changes in their environment involve transcriptional regulation in which a transcriptional regulator responds to signal(s) from the environment and regulates (positively or negatively) the expression of several genes or operons. Some of these regulators exert a positive feedback on their own expression. This is a necessary (although not sufficient) condition for the occurrence of multistationarity. One biological consequence of multistationarity may be epigenetic modifications, a hypothesis unusual to microbiologists, in spite of some well-known epigenetic modifications in bacteria. We propose here that the occurrence of mucoidy in the opportunistic pathogen Pseudomonas aeruginosa, which is currently attributed to mutations only, may also be an epigenetic modification. A theoretical approach using a generalised logical analysis lends credit to this hypothesis and suggests experiments to ascertain it.
Acta Biotheoretica – Springer Journals
Published: Oct 26, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.