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Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate Frameworks: Morphology, Drug Release, Hemocompatibility and Shape Memory Studies

Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate... Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepared for vascular tissue application. In this line, ZIF-8@Asp NPs were synthesized, and their characterization revealed their average NP size and the drug loading efficiency of approximately 180 nm and 76 %. Afterward, ZIF-8@Asp NPs were loaded into PLA nanofibers and the obtained results showed a uniform morphology with an average nanofibers diameter of around 544 nm, Young’s modulus of 1.7 MPa, and the ultimate drug release of 19 % after six days. Besides degradation studies of the sample, the addition of ZIF-8@Asp NPs to the PLA nanofibers displayed no adverse effect on the shape recovery properties. Finally, the hemolysis and platelet adhesion confirmed that the surface of the ZIF-8@Asp-loaded PLA nanofibrous samples exhibited appropriate hemocompatibility. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fibers and Polymers Springer Journals

Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate Frameworks: Morphology, Drug Release, Hemocompatibility and Shape Memory Studies

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Publisher
Springer Journals
Copyright
Copyright © The Korean Fiber Society 2022
ISSN
1229-9197
eISSN
1875-0052
DOI
10.1007/s12221-022-4163-7
Publisher site
See Article on Publisher Site

Abstract

Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepared for vascular tissue application. In this line, ZIF-8@Asp NPs were synthesized, and their characterization revealed their average NP size and the drug loading efficiency of approximately 180 nm and 76 %. Afterward, ZIF-8@Asp NPs were loaded into PLA nanofibers and the obtained results showed a uniform morphology with an average nanofibers diameter of around 544 nm, Young’s modulus of 1.7 MPa, and the ultimate drug release of 19 % after six days. Besides degradation studies of the sample, the addition of ZIF-8@Asp NPs to the PLA nanofibers displayed no adverse effect on the shape recovery properties. Finally, the hemolysis and platelet adhesion confirmed that the surface of the ZIF-8@Asp-loaded PLA nanofibrous samples exhibited appropriate hemocompatibility.

Journal

Fibers and PolymersSpringer Journals

Published: Aug 1, 2022

Keywords: PLA; ZIF-8; Aspirin; Nanofiber; Platelet

References