Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Platelet variables in healthy dogs: reference intervals and influence of age, breed and sex

Platelet variables in healthy dogs: reference intervals and influence of age, breed and sex Platelet parameters are routinely available and might be valuable in veterinary diagnostics. The aim of this study was to assess influences of age, breed and sex on platelet parameters as well as to define reference ranges for dogs. Data of 166 healthy dogs were reviewed retrospectively. One hundred fifty-six dogs aged >1 month to 8.5 years were categorised into five age groups. Reference intervals were determined for 119 adult dogs and for this subpopulation the influence of sex and neuter status was examined. Breeds with n ≥ 5 individuals were statistically compared; these included 11 Havanese dogs, 11 Rhodesian Ridgebacks, 9 Labrador Retrievers, 8 Golden Retrievers and 5 German Shepherds. Blood analysis was performed using the ADVIA® 120 haematology analyser. The following parameters were assessed: platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), mean platelet component (MPC), platelet component distribution width (PCDW), mean platelet mass (MPM), platelet mass distribution width (PMDW), large platelets and platelet clump count. Puppies had significantly higher values for all platelet variables except MPC and PCDW. Significant breed differences were observed for PLT, PDW, PCT, MPC, MPM and PMDW. Significant sex differences were only seen for mean PLT (females, 320 × 103/μl; males, 272 × 103/μl; p = 0.003) as well as median MPV (females, 10.5 fl; males, 11.0 fl; p = 0.043). The influence of age and breed should be considered in clinical interpretation of canine platelet variables. Calculated reference intervals may deliver useful information for an increasing clinical use of examined parameters. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Platelet variables in healthy dogs: reference intervals and influence of age, breed and sex

Download PDF
10 pages

Loading next page...
 
/lp/springer-journals/platelet-variables-in-healthy-dogs-reference-intervals-and-influence-7JS20e6wCu
Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-016-2305-2
Publisher site
See Article on Publisher Site

Abstract

Platelet parameters are routinely available and might be valuable in veterinary diagnostics. The aim of this study was to assess influences of age, breed and sex on platelet parameters as well as to define reference ranges for dogs. Data of 166 healthy dogs were reviewed retrospectively. One hundred fifty-six dogs aged >1 month to 8.5 years were categorised into five age groups. Reference intervals were determined for 119 adult dogs and for this subpopulation the influence of sex and neuter status was examined. Breeds with n ≥ 5 individuals were statistically compared; these included 11 Havanese dogs, 11 Rhodesian Ridgebacks, 9 Labrador Retrievers, 8 Golden Retrievers and 5 German Shepherds. Blood analysis was performed using the ADVIA® 120 haematology analyser. The following parameters were assessed: platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), mean platelet component (MPC), platelet component distribution width (PCDW), mean platelet mass (MPM), platelet mass distribution width (PMDW), large platelets and platelet clump count. Puppies had significantly higher values for all platelet variables except MPC and PCDW. Significant breed differences were observed for PLT, PDW, PCT, MPC, MPM and PMDW. Significant sex differences were only seen for mean PLT (females, 320 × 103/μl; males, 272 × 103/μl; p = 0.003) as well as median MPV (females, 10.5 fl; males, 11.0 fl; p = 0.043). The influence of age and breed should be considered in clinical interpretation of canine platelet variables. Calculated reference intervals may deliver useful information for an increasing clinical use of examined parameters.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Aug 26, 2016

References

  • Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis
    Albayrak, Y; Albayrak, A; Albayrak, F; Yildirim, R; Aylu, B; Uyanik, A; Kabalar, E; Güzel, IC
  • Platelet distribution width and mean platelet volume in the interpretation of thrombocytopenia in dogs
    Bommer, NX; Shaw, DJ; Milne, EM; Ridyard, AE
  • Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?
    Bord, S; Vedi, S; Beavan, SR; Horner, A; Compston, JE
  • Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors alpha and beta
    Bord, S; Frith, E; Ireland, DC; Scott, MA; Craig, JI; Compston, JE
  • Comparison of platelet number, mean platelet volume and platelet mass in five mammalian species
    Boudreaux, MK; Ebbe, S
  • The determination of a reference range for new platelet parameters produced by the Bayer ADVIATM 120 full blood count analyser
    Brummitt, DR; Barker, HF
  • Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men
    Butkiewicz, AM; Kemona, H; Dymicka-Piekarska, V; Matowicka-Karna, J; Radziwon, P; Lipska, A
  • Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis
    Çil, H; Yavuz, C; İslamoğlu, Y; Tekbaş, EÖ; Demirtaş, S; Atılgan, ZA; Gündüz, E; Benli, ED; Tanrıverdi, H
  • Clinical and laboratory-diagnosed parameters in 21 dogs with primary immune-mediated thrombocytopenia
    Dircks, B; Schuberth, HJ; Mischke, R
  • Definition of reference ranges for the platelet distribution width (PDW): a local need
    Farias, MG; Schunck, EG; Dal Bó, S; Castro, SM
  • ASVCP reference interval guidelines: determination of de novo reference intervals in veterinary species and other related topics
    Friedrichs, KR; Harr, KE; Freeman, KP; Szladovits, B; Walton, RM; Barnhart, KF; Blanco-Chavez, J
  • Evaluation of platelet analysis on the ADVIA 120 hematology system
    Giacomini, A; Legovini, P; Antico, F; Gessoni, G; Valverde, S; Salvadego, MM; Manoni, F
  • Platelet count and parameters determined by the Bayer ADVIATM 120 in reference subjects and patients
    Giacomini, A; Legovini, P; Gessoni, G; Antico, F; Valverde, S; Salvadego, MM; Manoni, F
  • Age-related changes in thrombopoietin levels
    Ishiguro, A; Nakahata, T; Matsubara, K; Hayashi, Y; Kato, T; Suzuki, Y; Shimbo, T
  • Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia
    Kaito, K; Otsubo, H; Usui, N; Yoshida, M; Tanno, J; Kurihara, E; Matsumoto, K; Hirata, R; Domitsu, K; Kobayashi, M
  • Prognostic value of platelet indices as determined by ADVIA 120 in patients suspected of having disseminated intravascular coagulation
    Kim, HK; Kim, JE; Ham, CK; Lee, DS; Park, S; Cho, HI
  • Platelet measurements in rat, dog and mouse blood samples using the Sysmex XT-2000iV
    Mathers, RA; Evans, GO; Bleby, J
  • Quantification of thrombopoietic activity in bone marrow aspirates of dogs
    Mischke, R; Busse, L; Bartels, D; Glaser, S; Kreienbrock, L
  • Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol
    Nagata, Y; Yoshikawa, J; Hashimoto, A; Yamamoto, M; Payne, AH; Todokoro, K
  • Platelet function in dogs: breed differences and effect of acetylsalicylic acid administration
    Nielsen, LA; Zois, NE; Pedersen, HD; Olsen, LH; Tarnow, I
  • Diagnosis of microthrombocytosis and immune-mediated thrombocytopenia in dogs with thrombocytopenia: 68 cases (1987-1989)
    Northern, J; Tvedten, HW
  • Evaluation of mean platelet volume in the differential diagnosis of thrombocytopenia
    Ntaios, G; Papadopoulos, A; Chatzinikolaou, A; Girtovitis, F; Kaiafa, G; Savopoulos, C; Hatzitolios, A
  • Effects of high-dose estrogen on murine hematopoietic bone marrow precede those on osteogenesis
    Perry, MJ; Samuels, A; Bird, D; Tobias, JH
  • Hemogram in normal newborn babies with special reference to platelet count
    Sasanakul, W; Singalavanija, S; Hathirat, P; Mahaphan, W; Chuansumrit, A
  • Platelet counts differ by sex, ethnicity, and age in the United States
    Segal, JB; Moliterno, AR
  • Platelet parameters from an automated hematology analyzer in dogs with inflammatory clinical diseases
    Smith, JR; Smith, KF; Brainard, BM
  • Thrombopoietin (Tpo) in the fetus and neonate: Tpo concentrations in preterm and term neonates, and organ distribution of Tpo and its receptor (c-mpl) during human fetal development
    Sola, MC; Juul, SE; Meng, YG; Garg, S; Sims, P; Calhoun, DA; Dame, JB; Christensen, D
  • Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia
    Yilmaz, Z; Eralp, O; Ilcol, YO
  • Erythrocyte and platelet indices in babesiosis of dogs
    Žvorc, Z; Rafaj, RB; Kuleš, J; Mrljak, V