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Plasma fibrinogen concentration is increased following depletion of vitamin K-dependent clotting factors by the indirect anticoagulant difenacoum in norway rats (Rattus norvegicus)

Plasma fibrinogen concentration is increased following depletion of vitamin K-dependent clotting... Difenacoum, a 4-hydroxycoumarin anticoagulant rodenticide with the same mode of action as warfarin, was fed to four strains of rat in medium oatmeal at 0.005% (w/w) for five days. The four rat strains had differing degrees of resistance to the anticoagulant difenacoum. Prothrombin time, factor X and fibrinogen concentration were monitored daily throughout the feeding period, and for a further 8 days following feeding. After 24 h factor X had been reduced in susceptible rats to 25% and fibrinogen had increased to 110% of resting levels. By 48 h prothrombin times were so extended that it was impossible to estimate the levels of fibrinogen in rats of this susceptible strain beyond that time point. As factor X levels reduced, fibrinogen levels increased in the plasma of rats with medium resistance levels. Feeding of difenacoum to highly resistant rats caused little, if any, extension of prothrombin time and enabled further comparison of fibrinogen and factor X levels in these animals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Plasma fibrinogen concentration is increased following depletion of vitamin K-dependent clotting factors by the indirect anticoagulant difenacoum in norway rats (Rattus norvegicus)

Comparative Clinical Pathology , Volume 9 (2) – Mar 7, 2007

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1999 by Springer-Verlag
Subject
Medicine & Public Health; Hematology; Oncology; Pathology
eISSN
1433-2973
DOI
10.1007/BF02585540
Publisher site
See Article on Publisher Site

Abstract

Difenacoum, a 4-hydroxycoumarin anticoagulant rodenticide with the same mode of action as warfarin, was fed to four strains of rat in medium oatmeal at 0.005% (w/w) for five days. The four rat strains had differing degrees of resistance to the anticoagulant difenacoum. Prothrombin time, factor X and fibrinogen concentration were monitored daily throughout the feeding period, and for a further 8 days following feeding. After 24 h factor X had been reduced in susceptible rats to 25% and fibrinogen had increased to 110% of resting levels. By 48 h prothrombin times were so extended that it was impossible to estimate the levels of fibrinogen in rats of this susceptible strain beyond that time point. As factor X levels reduced, fibrinogen levels increased in the plasma of rats with medium resistance levels. Feeding of difenacoum to highly resistant rats caused little, if any, extension of prothrombin time and enabled further comparison of fibrinogen and factor X levels in these animals.

Journal

Comparative Clinical PathologySpringer Journals

Published: Mar 7, 2007

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