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J. Greaves, P. Ayres (1967)
Heritable Resistance to Warfarin in RatsNature, 215
D. Drummond, E. Wilson (1968)
Laboratory investigations of resistance to warfarin of Rattus norvegicus Berk. In Montgome norvegicus Berk. in Montgomeryshire and Shropshire.The Annals of applied biology, 61 2
J. Stenflo, J. Suttie (1977)
Vitamin K-dependent formation of gamma-carboxyglutamic acid.Annual review of biochemistry, 46
Z. Amirat, R. Brudieux (1993)
Seasonal changes in in vivo cortisol response to ACTH and in plasma and pituitary concentrations of ACTH in a desert rodent, the sand rat (Psammomys obesus).Comparative biochemistry and physiology. Comparative physiology, 104 1
(1988)
The role of altered vitamin K metabolism in anticoagulant resistance in rodents
G. Miller (1992)
Environmental influences on hemostasis and thrombosis. Diet and smoking.Annals of epidemiology, 2 4
DC Drummond, EJ Wilson (1968)
Laboratory investigations of resistance to warfarin ofRattus norvegicus Berk. in Montgomeryshire and ShropshireAnn Appl Biol, 61
J. Gill, G. Kerins, S. Langton, A. MacNicoll (1994)
Blood-clotting response test for bromadiolone resistance in Norway ratsJournal of Wildlife Management, 58
R. Redfern, J. Gill (1978)
The development and use of a test to identify resistance to the anticoagulant difenacoum in the Norway rat (Rattus norvegicus)Journal of Hygiene, 81
A. Martin, L. Steed, R. Redfern, J. Gill, L. Huson (1979)
Warfarin-Resistance Genotype Determination in the Norway Rat, Rattus NorvegicusLaboratory Animals, 13
(1992)
Environmental influences on haemostasi and thrombosis : diet andsmoking
A. Yacobi, G. Levy (1974)
Pharmacokinetics of the warfarin enantiomers in ratsJournal of Pharmacokinetics and Biopharmaceutics, 2
A. Zimmermann, J. Matschiner (1974)
Biochemical basis of hereditary resistance to warfarin in the rat.Biochemical pharmacology, 23 6
J. Gill, G. Kerins, S. Langton, A. MacNicoll (1993)
The development of a blood clotting response test for discriminating between difenacoum-resistant and susceptible Norway rats (Rattus norvegicus, Berk.).Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 104 1
T. Harauchi, K. Takano, M. Matsuura, T. Yoshizaki (1986)
Liver and plasma levels of descarboxyprothrombin (PIVKA II) in vitamin K deficiency in rats.Japanese journal of pharmacology, 40 4
J. Gill, G. Kerins, A. MacNicoll (1992)
Inheritance of low grade brodifacoum resistance in the Norway ratJournal of Wildlife Management, 56
(1987)
Evidence of a common binding site in vivo for the retention of anticoagulants in rat liver
J. Suttie, C. Jackson (1977)
Prothrombin structure, activation, and biosynthesis.Physiological reviews, 57 1
R. Cook, T. Williams (1972)
Proceedings of the Association of Applied BiologistsAnnals of Applied Biology, 71
(1975)
Instructionsfor determiningthe susceptibility or resistanceof rodents to anticoagulants
G. Kerins, A. MacNicoll (1999)
Comparison of the half-lives and regeneration rates of blood clotting factors II, VII, and X in anticoagulant-resistant and susceptible Norway rats (Rattus norvegicus Berk.).Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 122 3
AD MacNicoll (1988)
Seventeenth Steenbock symposium on current advances in vitamin K research
(1988)
Genetics of difenacoum resistance in the rat
Difenacoum, a 4-hydroxycoumarin anticoagulant rodenticide with the same mode of action as warfarin, was fed to four strains of rat in medium oatmeal at 0.005% (w/w) for five days. The four rat strains had differing degrees of resistance to the anticoagulant difenacoum. Prothrombin time, factor X and fibrinogen concentration were monitored daily throughout the feeding period, and for a further 8 days following feeding. After 24 h factor X had been reduced in susceptible rats to 25% and fibrinogen had increased to 110% of resting levels. By 48 h prothrombin times were so extended that it was impossible to estimate the levels of fibrinogen in rats of this susceptible strain beyond that time point. As factor X levels reduced, fibrinogen levels increased in the plasma of rats with medium resistance levels. Feeding of difenacoum to highly resistant rats caused little, if any, extension of prothrombin time and enabled further comparison of fibrinogen and factor X levels in these animals.
Comparative Clinical Pathology – Springer Journals
Published: Mar 7, 2007
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