Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Alkreathy, R. Khan, Muhammad Khan, Sumaira Sahreen (2014)
CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensisBMC Complementary and Alternative Medicine, 14
S. Roberts, R. James, M. Franklin (2003)
Hepatotoxicity: Toxic Effects on the Liver
S. Sen, R. Chakraborty (2016)
Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and futureJournal of Traditional and Complementary Medicine, 7
Fabiana Vilela, R. Soncini, A. Giusti-Paiva (2009)
Anxiolytic-like effect of Sonchus oleraceus L. in mice.Journal of ethnopharmacology, 124 2
Shivaraj Gowda, P. Desai, Shruthi Kulkarni, Vinayak Hull, Avinash Math, Sonal Vernekar (2010)
Markers of renal function testsNorth American Journal of Medical Sciences, 2
M. Agra, G. Baracho, Kiriaki Nurit, I. Basílio, V. Coelho (2007)
Medicinal and poisonous diversity of the flora of "Cariri Paraibano", Brazil.Journal of ethnopharmacology, 111 2
S. Bhandary, S. Kumari, V. Bhat, M. Bekal (2012)
PRELIMINARY PHYTOCHEMICAL SCREENING OF VARIOUS EXTRACTS OF PUNICA GRANATUM PEEL, WHOLE FRUIT AND SEEDS, 02
J. Karlberg (2001)
General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine
Imir Metushi, Ping Cai, Xu Zhu, Tetsuya Nakagawa, Jack Uetrecht (2011)
A Fresh Look at the Mechanism of Isoniazid‐Induced HepatotoxicityClinical Pharmacology & Therapeutics, 89
C. Marzolini, E. Paus, T. Buclin, R. Kim (2004)
Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical RelevanceClinical Pharmacology & Therapeutics, 75
O. Lv, Lifang Wang, Jianke Li, Q. Ma, Wei Zhao (2016)
Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway.Food & function, 7 12
K. John, M. Ayyanar, T. Arumugam, G. Enkhtaivan, Kijoun Jin, D. Kim (2015)
Phytochemical screening and antioxidant activity of different solvent extracts from Strychnos minor Dennst leavesAsian Pacific Journal of Tropical Disease, 5
A. Rizk, F. Hammouda, S. Ismail, N. Hassan, M. El-Missiry, Faheem Ahmad (1983)
Constituents of plants growing in QatarPlant Foods for Human Nutrition, 40
R. Havel (1969)
Pathogenesis, differentiation and management of hypertriglyceridemia.Advances in internal medicine, 15
Haidan Yuan, Q. Ma, L. Ye, Guangchun Piao (2016)
The Traditional Medicine and Modern Medicine from Natural ProductsMolecules, 21
Abhijeet V.Puri, Prakash D.Khandagale, Yunus Ansari (2018)
A REVIEW ON ETHNOMEDICINAL, PHARMACOLOGICAL AND PHYTOCHEMICAL ASPECTS OF SONCHUS OLERACEUS LINN. (ASTERACEAE)
L. Kubena, R. Harvey, W. Huff, M. Elissalde, A. Yersin, T. Phillips, G. Rottinghaus (1993)
Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and diacetoxyscirpenol.Poultry science, 72 1
Alexander Birbrair, P. Frenette (2016)
Niche heterogeneity in the bone marrowAnnals of the New York Academy of Sciences, 1370
Z. Muhammad, Shabir Ahmad, R. Ullah, F. Ullah, Saleem Jan (2012)
Isolation and Characterization of Two New Compounds from Genus SonchusBiomedical and Pharmacology Journal, 5
E. Iqbal, K. Salim, Linda Lim (2015)
Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei DarussalamJournal of King Saud University - Science, 27
R. Khan, Muhammad Khan, Sumaira Sahreen, N. Shah (2012)
Hepatoprotective activity of Sonchus asper against carbon tetrachloride-induced injuries in male rats: a randomized controlled trialBMC Complementary and Alternative Medicine, 12
A. Hayes (1982)
Principles and methods of toxicology
T. Tatefuji, Miyako Yanagihara, Shinobu Fukushima, K. Hashimoto (2014)
Safety assessment of melinjo (Gnetum gnemon L.) seed extract: acute and subchronic toxicity studies.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 67
K. Janbaz, A. Gilani (1995)
Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.Journal of ethnopharmacology, 47 1
VP Abhijeet, DK Prakash, NA Yunus (2018)
A review on ethnomedicinal, pharmacological and a review on ethnomedicinal, pharmacological and phytochemical aspects of Sonchus oleraceus LINN (Asteraceae)IJPBS, 8
L. Navarro-Moreno, M. Quintanar-Escorza, S. González, Ricardo Mondragón, J. Cerbón-Solórzano, Jesús Valdés, J. Calderón-Salinas (2009)
Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells.Toxicology in vitro : an international journal published in association with BIBRA, 23 7
W. Bandaranayake (2006)
Quality control, screening, toxicity and regulations of herbal drugs
Zakia Khanam, C. Wen, I. Bhat (2015)
Phytochemical screening and antimicrobial activity of root and stem extracts of wild Eurycoma longifolia Jack (Tongkat Ali)Journal of King Saud University - Science, 27
(2009)
Pharmacognosie, phytochimie, plantes médicinales (4e éd.)
A. Adedapo, M. Abatan, A. Akinloye, S. Idowu, O. Olorunsogo (2003)
Morphometric and histopathological studies on the effects of some chromatographic fractions of Phyllanthus amarus and Euphorbia hirta on the male reproductive organs of rats.Journal of veterinary science, 4 2
Monchai Manassila, A. Nuntagij, P. Tittabutr, N. Boonkerd, N. Teaumroong (2012)
Growth, symbiotic, and proteomics studies of soybean Bradyrhizobium in response to adaptive acid toleranceAfrican Journal of Biotechnology, 11
Brenda Slavin (1985)
Clinical chemistry in diagnosis and treatmentThe Ulster Medical Journal, 54
(2018)
Isolation and structure elucidation of a flavone and tannic acid from Sudanese S.Oleraceus plant
A. Soussi, M. Gargouri, A. Feki (2018)
Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in ratsEnvironmental Toxicology, 33
A. Akindele, A. Adeneye, Oluwole Salau, M. Sofidiya, A. Benebo (2014)
Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav. (Malpighiaceae) in rodentsFrontiers in Pharmacology, 5
Ramachandran Vinayagam, Baojun Xu (2015)
Antidiabetic properties of dietary flavonoids: a cellular mechanism reviewNutrition & Metabolism, 12
V. Neergheen-Bhujun (2013)
Underestimating the Toxicological Challenges Associated with the Use of Herbal Medicinal Products in Developing CountriesBioMed Research International, 2013
M. Fuster, J. Esko (2005)
The sweet and sour of cancer: glycans as novel therapeutic targetsNature Reviews Cancer, 5
M. Al-Mamary, M. Al-Habori, A. Al-aghbari, M. Baker (2002)
Investigation into the toxicological effects of Catha edulis leaves: a short term study in animalsPhytotherapy Research, 16
Deepak Kumar, R. Ghosh, B. Pal (2013)
α-Glucosidase inhibitory terpenoids from Potentilla fulgens and their quantitative estimation by validated HPLC methodJournal of Functional Foods, 5
K. Smock, S. Perkins (2014)
Thrombocytopenia: an updateInternational Journal of Laboratory Hematology, 36
J. Costa-Silva, C. Lima, Erick Silva, A. Araújo, M. Fraga, A. Ribeiro, A. Arruda, S. Lafayette, A. Wanderley (2008)
Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil.Journal of ethnopharmacology, 116 3
Rosidah, M. Yam, A. Sadikun, Maria Ahmad, G. Akowuah, M. Asmawi (2009)
Toxicology evaluation of standardized methanol extract of Gynura procumbens.Journal of ethnopharmacology, 123 2
(2014)
Prelminary phytochemical screening and in vitro antioxidant activity of extracts of whole plant of Sonchus oleraceus Asteraceae
M. Bahmani, H. Shirzad, S. Rafieian, M. Rafieian-kopaei (2015)
Silybum marianum: Beyond HepatoprotectionJournal of Evidence-Based Complementary & Alternative Medicine, 20
(1986)
Enzymes in serum, their volume in diagnosis
Tg (2018)
Repeated Dose 90-Day Oral Toxicity Study in Rodents (OECD TG 408)OECD Series on Testing and Assessment
T. Benn, Bohkyung Kim, Young-Ki Park, Yue Yang, T. Pham, C. Ku, Callie Farruggia, Ellen Harness, J. Smyth, Ji-Young Lee (2015)
Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.The British journal of nutrition, 113 11
S Schaffer, S Schmitt-Schillig, WE Muller, GP Eckert (2005)
Antioxidant properties of Mediterranean food plant extracts: geographical differencesJ Physiol Pharmacol Supplement, 56
C. Auletta (2001)
Acute, Subchronic, and Chronic Toxicology
Ting Liu, Xiao Yu, Enze Gao, X. Liu, Li Sun, Hua Li, Pei-le Wang, Yunli Zhao, Zhi-guo Yu (2014)
Hepatoprotective Effect of Active Constituents Isolated from Mung Beans (Phaseolus radiatus L.) in an Alcohol‐Induced Liver Injury Mouse ModelJournal of Food Biochemistry, 38
R. Khan, Muhammad Khan, Sumaira Sahreen, N. Shah, A. Khan, Y. Khan, Jasia Bokhari, U. Rashid, B. Ahmad, M. Shabbir, Naima Saeed, Shumaila Jan, Tayyaba Afsar (2012)
Amelioration of kidney function markers by Sonchus asper butanolic extract against KBrO3-induced toxicity in ratJournal of Medicinal Plants Research, 6
M. Builders, C. Isichie, J. Aguiyi (2012)
Toxicity Studies of the Extracts of Parkia biglobosa Stem Bark in RatsBritish journal of pharmaceutical research, 2
(2009)
Evaluation of prospective hypocholesterolemic effect and preliminary toxicology of crude extract and decoction from Vitex megapotamica (Spreng) Moldenke (V. montevidensis Cham.) in vivo
OS Olorunnisola, G Bradley, AJ Afolayan (2012)
Acute and sub-chronic toxicity studies of methanolic extract of Tulbaghia violacea rhizomes in Wistar ratsAfr J Biotech, 11
Zeinab Zgheir, N. Yaseen, T. Makkawi (2012)
STUDY OF THE EFFECT OF CRUDE EXTRACTS OF Sonchus oleraceus ON CANCER CELL GROWTH ( In vivo ) * *
V. Liju, K. Jeena, R. Kuttan (2013)
Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L).Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53
S. Venkateswaran, L. Pari, P. Viswanathan, V. Menon (1997)
Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats.Journal of ethnopharmacology, 57 3
P. Quézel, S. Santa, O. Schotter (1962)
Nouvelle flore de l'Algerie et des regions desertiques meridionales - v. 1-2
K. Gabriel (1964)
VETERINARY TOXICOLOGYAnnals of the New York Academy of Sciences, 111
M. Ezeja, A. Anaga, I. Asuzu (2014)
Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats.Journal of ethnopharmacology, 151 3
Saifur Khan, Andrew Morgan, K. Michail, Nutan Srivastava, R. Whittal, N. Aljuhani, A. Siraki (2016)
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.Biochemical pharmacology, 106
K. Hata, Kyoko Ishikawa, K. Hori, T. Konishi (2000)
Differentiation-inducing activity of lupeol, a lupane-type triterpene from Chinese dandelion root (Hokouei-kon), on a mouse melanoma cell line.Biological & pharmaceutical bulletin, 23 8
Fatine Aissani, N. Grara, C. Bensouici, A. Bousbia, Hayette Ayed, M. Idris, L. Teh (2021)
Algerian Sonchus oleraceus L.: a comparison of different extraction solvent on phytochemical composition, antioxidant properties and anti-cholinesterase activityAdvances in Traditional Medicine, 22
R. Khan, Muhammad Khan, Sumaira Sahreen, Mushtaq Ahmed (2012)
Evaluation of phenolic contents and antioxidant activity of various solvent extracts of Sonchus asper (L.) HillChemistry Central Journal, 6
Duangjai Tungmunnithum, Areeya Thongboonyou, Apinan Pholboon, Aujana Yangsabai (2018)
Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An OverviewMedicines, 5
R. Mehta, J. Kellum, Sudhir Shah, B. Molitoris, C. Ronco, D. Warnock, A. Levin (2007)
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injuryCritical Care, 11
O. Adeyemi, C. Osubor (2010)
Toxicological evaluation of the effect of Clarias gariepinus (African catfish) cultivated in water contaminated with phthalate, benzene and cyclohexane on liver of albino rats.African Journal of Food Science, 4
Meriam Tir, A. Feriani, Arbia Labidi, A. Mufti, E. Saadaoui, N. Nasri, A. Khaldi, M. Cafsi, Nizar Tlili (2019)
Protective effects of phytochemicals of Capparis spinosa seeds with cisplatin and CCl4 toxicity in miceFood Bioscience
D. Lorke (1983)
A new approach to practical acute toxicity testingArchives of Toxicology, 54
Respect for life. National Institute of environment
D.M.W. Anderson (1975)
Industrial Gums, Polysaccharides and their DerivativesCarbohydrate Research, 41
O. Martey, G. Armah, L. Okine (2010)
Absence of organ specific toxicity in rats treated with Tonica, an aqueous herbal haematinic preparation.African journal of traditional, complementary, and alternative medicines : AJTCAM, 7 3
A. Sundberg, E. Appelkvist, G. Dallner, Robert Nilsson (1994)
Glutathione transferases in the urine: sensitive methods for detection of kidney damage induced by nephrotoxic agents in humans.Environmental Health Perspectives, 102
M. Smach, J. Hafsa, B. Charfeddine, H. Dridi, K. Limem (2015)
Effects of sage extract on memory performance in mice and acetylcholinesterase activity.Annales pharmaceutiques francaises, 73 4
C. Teugwa, Pascaline Mejiato, Denis Zofou, Bruno Tchinda, F. Boyom (2013)
Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae)BMC Complementary and Alternative Medicine, 13
F. Jimoh, A. Adedapo, A. Afolayan (2011)
Comparison of the nutritive value, antioxidant and antibacterial activities of Sonchus asper and Sonchus oleraceus
S. Khan, Jonathan Epstein, K. Olival, M. Hassan, Mamdud Hossain, Kaisar Rahman, M. Elahi, Mohammad Mamun, Najmul Haider, G. Yasin, James Desmond (2011)
Hematology and serum chemistry reference values of stray dogs in BangladeshOpen Veterinary Journal, 1
S. Balogun, Iberê Silva, E. Colodel, Ruberlei Oliveira, S. Ascêncio, D. Martins (2014)
Toxicological evaluation of hydroethanolic extract of Helicteres sacarolha A. St.- Hil. et al.Journal of ethnopharmacology, 157
Madhuvanthi Ramaiah, Ajay Jain, J. Baldwin, A. Karthikeyan, K. Raghothama (2011)
Characterization of the Phosphate Starvation-Induced Glycerol-3-phosphate permease Gene Family in Arabidopsis1[C][W][OA]Plant Physiology, 157
H. Ginsberg, Yuan-Li Zhang, A. Hernandez-Ono (2006)
Metabolic Syndrome: Focus on DyslipidemiaObesity, 14
H. Olson, G. Betton, D. Robinson, K. Thomas, A. Monro, G. Kolaja, P. Lilly, James Sanders, Glenn Sipes, W. Bracken, M. Dorato, Koen Deun, Peter Smith, B. Berger, Allen Heller (2000)
Concordance of the toxicity of pharmaceuticals in humans and in animals.Regulatory toxicology and pharmacology : RTP, 32 1
Fabiana Vilela, Marina Padilha, Lucas Santos-E-Silva, Geraldo Alves-da-Silva, A. Giusti-Paiva (2009)
Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice.Journal of ethnopharmacology, 124 2
S. Kassaee, M. Goodarzi, N. Roodbari, P. Yaghmaei (2016)
The Effects of Cinnamomum zeylanicum on Lipid Profiles and Histology Via Up-Regulation of LDL Receptor Gene Expression in Hamsters Fed a High Cholesterol DietJundishapur Journal of Natural Pharmaceutical Products, 12
Ibadet Tohti, M. Tursun, A. Umar, S. Turdi, Horyat Imin, N. Moore (2006)
Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio--venous shunt thrombosis in vivo.Thrombosis research, 118 6
K. N’guessan, B. Kadja, G. Zirihi, Dossahoua Traoré, L. Aké-Assi (2009)
Screening phytochimique de quelques plantes médicinales ivoiriennes utilisées en pays Krobou (Agboville, Côte-d'Ivoire), 6
S. Schaffer, S. Schmitt-Schillig, Walter Müller, G. Eckert (2005)
Antioxidant properties of Mediterranean food plant extracts: geographical differences.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56 Suppl 1
Kwan Ping, I. Darah, Yeng Chen, S. Sreeramanan, S. Sasidharan (2013)
Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in RatsBioMed Research International, 2013
Babu Thapa, A. Walia (2007)
Liver function tests and their interpretationThe Indian Journal of Pediatrics, 74
B. Saad, H. Azaizeh, G. Abu-Hijleh, O. Said (2006)
Safety of Traditional Arab Herbal MedicineEvidence-based Complementary and Alternative Medicine, 3
Liliani Thiesen, Maria Nunes, C. Meyre-Silva, Veronica Pastor, S. Andrade, Angélica Couto, L. Silva, T. Bresolin, J. Santin (2018)
The hydroethanolic Litchi chinensis leaf extract alleviate hepatic injury induced by carbon tetrachloride (CCl4) through inhibition of hepatic inflammation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107
R. Mcelreath, Barney Luttbeg, S. Fogarty, T. Brodin, A. Sih (2007)
Evolution of animal personalitiesNature, 450
Harmonised integrated classification system for human health and environmental hazards of chemical substances and mixtures
Huifeng Wu, Xiaoyu Zhang, Xiaojing Li, Yijie Wu, F. Pei (2005)
Acute biochemical effects of La(NO3)3 on liver and kidney tissues by magic-angle spinning 1H nuclear magnetic resonance spectroscopy and pattern recognition.Analytical biochemistry, 339 2
Reetika Singh, N. Kumari (2015)
Comparative determination of phytochemicals and antioxidant activity from leaf and fruit of Sapindus mukorrossi Gaertn. – A valuable medicinal treeIndustrial Crops and Products, 73
D. Hooper, S. Spitsin, R. Kean, J. Champion, G. Dickson, I. Chaudhry, H. Koprowski (1998)
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America, 95 2
Sonchus oleraceus L. is a Mediterranean leafy vegetable. The aerial parts are widely used in Algerian traditional medicine to treat several diseases such as inflammation, hepatitis, and for detoxication. To date, there are no studies corroborating its toxicity profile. This work aimed to investigate the qualitative phytochemical screening (QPS) and to evaluate the toxicity of the hydro-methanolic (HME) and hot aqueous (HAE) extracts of the aerial parts of S. oleraceus L. in female mice. The QPS of both extracts was achieved using simple tests, as well as the acute and subacute toxicities were examined following Lorke’s method and OECD guidelines 407, respectively. The qualitative phytochemical analysis revealed the presence of polyphenols, flavonoids, sterols and triterpenes, anthraquinone glycoside, and reducing compounds in both extracts. The administered doses of the two extracts disclosed no mortality and no visible sign of toxicity. The LD50 was estimated above 5 g/kg body weight. In the subacute test, the extracts did not induce neither mortality nor significant changes in body weight and relative organ weights. The data also revealed that HME leads to a disturbance in LDL, indirect bilirubin, while HAE caused a disorder in cholesterol, ALT, urea, creatinine, and total proteins levels. They caused as well a strong disturbance of hematological parameters. Histopathological examination showed an important hepatic, renal, and lung lesions up to the dose of 2000 mg/kg b.w. Our results showed that the two extracts may elicit toxic effects on the liver, kidney, and lung on prolonged administration.
Comparative Clinical Pathology – Springer Journals
Published: Jun 1, 2022
Keywords: Sonchus oleraceus L.; Phytochemical screening; Acute toxicity; Subacute toxicity; LD50; Biochemical and hematological parameters
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.