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Pharmacokinetics in Cancer Treatment

Pharmacokinetics in Cancer Treatment The design of chemotherapy schedules for treatment of malignancies is based on the selection of optimal drug doses with tolerable adverse effects. Interindividual variation in absorption, distribution, metabolism and excretion may exist for a given dose, which depend on both physiological and pathological factors. These factors will be of importance for the outcome of treatment in terms of efficacy as well as toxicity. As chemotherapy usually consists of a combination of drugs, pharmacological interactions may be expected. This also holds for other drug classes, such as analgesics, antidepressants, antibiotics, that are frequently coadministered to patients receiving chemotherapy. The study of pharmacokinetics can give insight in to the extent of interindividual variability based on genetic and patient factors, as well as in the occurrence of drug interactions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cancer Springer Journals

Pharmacokinetics in Cancer Treatment

American Journal of Cancer , Volume 1 (1) – Aug 9, 2012

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Publisher
Springer Journals
Copyright
Copyright © 2002 by Adis International Limited
Subject
Pharmacy; Pharmacy
ISSN
1175-6357
DOI
10.2165/00024669-200201010-00005
Publisher site
See Article on Publisher Site

Abstract

The design of chemotherapy schedules for treatment of malignancies is based on the selection of optimal drug doses with tolerable adverse effects. Interindividual variation in absorption, distribution, metabolism and excretion may exist for a given dose, which depend on both physiological and pathological factors. These factors will be of importance for the outcome of treatment in terms of efficacy as well as toxicity. As chemotherapy usually consists of a combination of drugs, pharmacological interactions may be expected. This also holds for other drug classes, such as analgesics, antidepressants, antibiotics, that are frequently coadministered to patients receiving chemotherapy. The study of pharmacokinetics can give insight in to the extent of interindividual variability based on genetic and patient factors, as well as in the occurrence of drug interactions.

Journal

American Journal of CancerSpringer Journals

Published: Aug 9, 2012

References