The design of chemotherapy schedules for treatment of malignancies is based on the selection of optimal drug doses with tolerable adverse effects. Interindividual variation in absorption, distribution, metabolism and excretion may exist for a given dose, which depend on both physiological and pathological factors. These factors will be of importance for the outcome of treatment in terms of efficacy as well as toxicity. As chemotherapy usually consists of a combination of drugs, pharmacological interactions may be expected. This also holds for other drug classes, such as analgesics, antidepressants, antibiotics, that are frequently coadministered to patients receiving chemotherapy. The study of pharmacokinetics can give insight in to the extent of interindividual variability based on genetic and patient factors, as well as in the occurrence of drug interactions.
American Journal of Cancer – Springer Journals
Published: Aug 9, 2012
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