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Charles White, M. McBride, Kayla Pate, A. Tieppo, M. Byrne (2011)
Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses.Biomaterials, 32 24
Jinah Kim, Anthony Conway, A. Chauhan (2008)
Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses.Biomaterials, 29 14
J. Ciolino, T. Hoare, Naomi Iwata, I. Behlau, C. Dohlman, R. Langer, D. Kohane (2009)
A drug-eluting contact lens.Investigative ophthalmology & visual science, 50 7
Furqan Maulvi, T. Soni, D. Shah (2015)
Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndromeJournal of Biomaterials Science, Polymer Edition, 26
Vicente Martín-Montañéz, A. López-Miguel, C. Arroyo, M. Mateo, J. González-Méijome, M. Calonge, M. González-García (2014)
Influence of environmental factors in the in vitro dehydration of hydrogel and silicone hydrogel contact lenses.Journal of biomedical materials research. Part B, Applied biomaterials, 102 4
A. Tieppo, Charles White, A. Paine, M. Voyles, Matthew McBride, Mark Byrne (2012)
Sustained in vivo release from imprinted therapeutic contact lenses.Journal of controlled release : official journal of the Controlled Release Society, 157 3
F. Yáñez, A. Concheiro, C. Alvarez‐Lorenzo (2008)
Macromolecule release and smoothness of semi-interpenetrating PVP-pHEMA networks for comfortable soft contact lenses.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69 3
Charles White, A. Tieppo, M. Byrne (2011)
Controlled drug release from contact lenses: A comprehensive review from 1965-presentJournal of Drug Delivery Science and Technology, 21
P. Paradiso, R. Galante, L. Santos, A. Matos, R. Colaço, A. Serro, B. Saramago (2014)
Comparison of two hydrogel formulations for drug release in ophthalmic lenses.Journal of biomedical materials research. Part B, Applied biomaterials, 102 6
H. Jung, A. Chauhan (2012)
Temperature sensitive contact lenses for triggered ophthalmic drug delivery.Biomaterials, 33 7
Rhongsheng Zhang, M. Tang, A. Bowyer, R. Eisenthal, J. Hubble (2005)
A novel pH- and ionic-strength-sensitive carboxy methyl dextran hydrogel.Biomaterials, 26 22
Y. Qiu, Kinam Park (2001)
Environment-sensitive hydrogels for drug deliveryAdvanced Drug Delivery Reviews, 53
C. Alvarez‐Lorenzo, H. Hiratani, A. Concheiro (2006)
Contact lenses for drug deliveryAmerican Journal of Drug Delivery, 4
F. Holly (1981)
Tear Film Physiology and Contact Lens Wear. II. Contact Lens‐Tear Film InteractionOptometry and Vision Science, 58
Korsmeyer Wilker, N. Peppas (1981)
EFFECT OF THE MORPHOLOGY OF HYDROPHILIC POLYMERIC MATRICES ON THE DIFFUSION AND RELEASE OF WATER SOLUBLE DRUGSJournal of Membrane Science, 9
P. Ritger, N. Peppas (1987)
A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discsJournal of Controlled Release, 5
Masakazu Yamada, Hiroshi Mochizuki, M. Kawai, Mami Yoshino, Y. Mashima (1997)
Fluorophotometric measurement of pH of human tears in vivo.Current eye research, 16 5
H. R. Noh (2012)
10.7317/pk.2012.36.2.190Polym. Korea, 36
Furqan Maulvi, Dhara Lakdawala, A. Shaikh, Ankita Desai, Harsh Choksi, Rutvi Vaidya, K. Ranch, A. Koli, B. Vyas, D. Shah (2016)
In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society, 226
Hanin Bearat, B. Lee, J. Valdez, B. Vernon (2011)
Synthesis, Characterization and Properties of a Physically and Chemically Gelling Polymer System Using Poly(NIPAAm-co-HEMA-acrylate) and Poly(NIPAAm-co-cysteamine)Journal of Biomaterials Science, Polymer Edition, 22
M. Norn (1988)
Tear fluid pH in normals, contact lens wearers, and pathological casesActa Ophthalmologica, 66
L. Verestiuc, O. Năstăsescu, E. Barbu, Indrajeetsinh Sarvaiya, K. Green, J. Tsibouklis (2006)
Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation.Journal of biomedical materials research. Part A, 77 4
M. Abelson, I. Udell, J. Weston (1981)
Normal human tear pH by direct measurement.Archives of ophthalmology, 99 2
A. Mahomed, J. Wolffsohn, B. Tighe (2016)
Structural design of contact lens-based drug delivery systems; in vitro and in vivo studies of ocular triggering mechanisms.Contact lens & anterior eye : the journal of the British Contact Lens Association, 39 2
J. Thygesen, O. Jensen (1987)
pH changes of the tear fluid in the conjunctival sac during postoperative inflammation of the human eyeActa Ophthalmologica, 65
Hua Wei, Si-Xue Cheng, Xianzheng Zhang, R. Zhuo (2009)
Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriersProgress in Polymer Science, 34
Won-Il Rhim, Ho-Sun Lee, Y. Yun, H. Choi (2003)
Analysis of Tear Composition in Chronic BlepharitisJournal of The Korean Ophthalmological Society, 44
Kai Cai, Yong Huang, Jinlong Yang (2005)
A Synergistic Low-Toxicity Gelcasting System by Using HEMA and PVPJournal of the American Ceramic Society, 88
Bumsang Kim, N. Peppas (2003)
Poly(ethylene glycol)-containing Hydrogels for Oral Protein Delivery ApplicationsBiomedical Microdevices, 5
C. Alvarez‐Lorenzo, Haruyiki Hiratani, J. Gómez-Amoza, R. Martínez‐Pacheco, C. Souto, A. Concheiro (2002)
Soft contact lenses capable of sustained delivery of timolol.Journal of pharmaceutical sciences, 91 10
P. K. Sahoo D. Ray (2008)
10.4103/0973-8398.42501Asian J. Pharm., 4
Abstract In this study, we evaluated contact lenses as drug delivery media and the effect of tear physiological pH on drug release behavior. Anionic or cationic hydroxyethyl methacrylate (HEMA) lenses were polymerized with either vinylpyrrolidone (VP) or N-isopropylacrylamide (NIPAAm). The pH of artificial tears was prepared as between 5.8 and 8.35. One of common treatments, hydroxypropyl methylcellulose (HPMC), to dry eye disease was used as a test drug. As a result, drug releases from anionic 100% p-HEMA and p-HEMA-VP lens were both increased with increasing tear pH. However, released drug amounts from cationic the p-HEMA-NIPAAm lens were decreased with increasing pH. In weak basicity (pH 8.03), the p-HEMA-VP (20 wt%) lens swelled resulting releasing drugs 3.5 times more compared to in weak acidity (pH 5.80). On the other hand, the p-HEMA-NIPAAm (20 wt%) lens de-swelled in basic solution resulting decreased drug release compared to in acidic solution. The hydrogel contact lenses showed various physical properties and drug releasing properties including diffusion coefficients in response to ionization reactions between ionic groups in the lens and pH of solution. It suggests that hydrogel contact lens has potential as selective drug delivery media.
"Macromolecular Research" – Springer Journals
Published: Mar 1, 2018
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