Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/personalized-medicine-a-pediatric-perspective-OtZu9lTcJP
References (33)
-
L. Smit, V. Siroux, E. Bouzigon, M. Oryszczyn, M. Lathrop, F. Demenais, F. Kauffmann (2009)
CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults.American journal of respiratory and critical care medicine, 179 5
-
S.J. Brown, C.L. Relton, H. Liao (2008)
Filaggrin null mutations and childhood atopic eczema: a population-based case-control studyJ Allergy Clin Immunol, 121
-
J. Tellería, A. Blanco‐quirós, D. Varillas, A. Armentia, I. Fernández-Carvajal, M. Alonso, Ignacio Díez (2008)
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.Respiratory medicine, 102 6
-
C. Murray, A. Simpson, A. Custovic (2004)
Allergens, viruses, and asthma exacerbations.Proceedings of the American Thoracic Society, 1 2
-
M. Kang, So-Yeon Lee, Hyo-Bin Kim, Jinho Yu, Byoung-ju Kim, Won-Ah Choi, S. Jang, S. Hong (2008)
Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstrictionPharmacogenetics and Genomics, 18
-
H. Bisgaard, A. Simpson, C. Palmer, K. Bønnelykke, I. McLean, S. Mukhopadhyay, C. Pipper, L. Halkjaer, B. Lipworth, J. Hankinson, A. Woodcock, A. Custovic (2008)
Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat ExposurePLoS Medicine, 5
-
Edith Chen, Gregory Miller, H. Walker, J. Arevalo, Caroline Sung, Steve Cole (2008)
Genome-wide transcriptional profiling linked to social class in asthmaThorax, 64
-
J. Henderson, K. Northstone, Simon Lee, H. Liao, Yiwei Zhao, M. Pembrey, S. Mukhopadhyay, G. Smith, C. Palmer, W. McLean, A. Irvine (2008)
The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.The Journal of allergy and clinical immunology, 121 4
-
M. Moffatt, M. Kabesch, L. Liang, A. Dixon, D. Strachan, S. Heath, M. Depner, A. Berg, A. Bufe, E. Rietschel, A. Heinzmann, Burkard Simma, T. Frischer, S. Willis-Owen, K. Wong, T. Illig, C. Vogelberg, S. Weiland, E. Mutius, G. Abecasis, M. Farrall, I. Gut, G. Lathrop, W. Cookson (2007)
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthmaNature, 448
-
I. Laing, I. Laing, N. Klerk, S. Turner, P. Judge, C. Hayden, Lou Landau, J. Goldblatt, P. Souëf (2009)
Cross‐sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow‐up cohortClinical & Experimental Allergy, 39
-
F. Martinez (2007)
CD14, endotoxin, and asthma risk: actions and interactions.Proceedings of the American Thoracic Society, 4 3
-
M. Baldini, I. Lohman, M. Halonen, R. Erickson, P. Holt, F. Martinez (1999)
A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.American journal of respiratory cell and molecular biology, 20 5
-
E. Bouzigon, E. Corda, H. Aschard, M. Dizier, A. Boland, J. Bousquet, Nicolas Chateigner, F. Gormand, J. Just, N. Moual, P. Scheinmann, V. Siroux, D. Vervloet, D. Zélénika, I. Pin, F. Kauffmann, M. Lathrop, F. Demenais (2008)
Effect of 17q21 variants and smoking exposure in early-onset asthma.The New England journal of medicine, 359 19
-
Ji-Sun Jung, B. Park, H. Cheong, J. Bae, Ji-Hye Kim, H. Chang, T. Rhim, Jong-Sook Park, A. Jang, Young‐Mok Lee, Ki-Up Kim, S. Uh, J. Na, Yong‐Hoon Kim, Choon-Sik Park, H. Shin (2009)
Association of IL-17RB gene polymorphism with asthma.Chest, 135 5
-
S. Weidinger, M. O'Sullivan, T. Illig, H. Baurecht, M. Depner, E. Rodriguez, A. Ruether, N. Klopp, C. Vogelberg, S. Weiland, W. McLean, E. Mutius, Alan Irvine, M. Kabesch (2008)
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.The Journal of allergy and clinical immunology, 121 5
-
E. Kurt-Jones, Lana Popova, Laura Kwinn, L. Haynes, L. Jones, R. Tripp, E. Walsh, M. Freeman, D. Golenbock, L. Anderson, R. Finberg (2000)
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virusNature Immunology, 1
-
S. Dold, Matthias Wjst, E. Mutius, P. Reitmeir, E. Stiepel (1992)
Genetic risk for asthma, allergic rhinitis, and atopic dermatitis.Archives of Disease in Childhood, 67
-
C. Ober, Z. Tan, Ying Sun, J. Possick, Lin Pan, Raluca Nicolae, S. Radford, R. Parry, A. Heinzmann, K. Deichmann, L. Lester, J. Gern, R. Lemanske, D. Nicolae, J. Elias, G. Chupp (2008)
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.The New England journal of medicine, 358 16
-
G. Kearns, S. Abdel‐Rahman, S. Alander, D. Blowey, J. Leeder, R. Kauffman (2003)
Developmental pharmacology--drug disposition, action, and therapy in infants and children.The New England journal of medicine, 349 12
-
V. Berce, K. Repnik, U. Potočnik (2008)
Association of CCR5-delta32 Mutation with Reduced Risk of Nonatopic Asthma in Slovenian ChildrenJournal of Asthma, 45
-
C. Palmer, A. Irvine, A. Terron-Kwiatkowski, Yiwei Zhao, H. Liao, Simon Lee, D. Goudie, A. Sandilands, L. Campbell, F. Smith, G. O'Regan, R. Watson, Joanne Cecil, S. Bale, J. Compton, J. DiGiovanna, J. DiGiovanna, P. Fleckman, S. Lewis-jones, G. Arseculeratne, A. Sergeant, C. Munro, B. Houate, K. McElreavey, L. Halkjaer, H. Bisgaard, S. Mukhopadhyay, S. Mukhopadhyay, W. McLean (2006)
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitisNature Genetics, 38
-
H. Bisgaard, K. Bønnelykke, P. Sleiman, M. Brasholt, B. Chawes, Eskil Kreiner-Møller, M. Stage, Cecilia Kim, R. Tavendale, Florent Baty, C. Pipper, Colin Palmer, Hakon Hakonarsson (2009)
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.American journal of respiratory and critical care medicine, 179 3
-
J. Drazen, C. Yandava, L. Dubé, Natalie Szczerback, Richard Hippensteel, A. Pillari, E. Israel, N. Schork, E. Silverman, D. Katz, J. Drajesk (1999)
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatmentNature Genetics, 22
-
K. Carlsen, M. Løvik, Berit Granum, Petter Mowinckel, Kai-Håkon Carlsen (2006)
Soluble CD14 at 2 yr of age: Gender‐related effects of tobacco smoke exposure, recurrent infections and atopic diseasesPediatric Allergy and Immunology, 17
-
S. Brown, C. Relton, H. Liao, Yiwei Zhao, A. Sandilands, I. Wilson, J. Burn, N. Reynolds, W. McLean, H. Cordell
Atopic dermatitis and skin disease Filaggrin null mutations and childhood atopic eczema : A population-based case-control study -
I. Ungvári, Gergely Tölgyesi, Ágnes Semsei, A. Nagy, Károly Radosits, Marton Keszei, G. Kozma, A. Falus, C. Szalai (2007)
CCR5Δ32 mutation, Mycoplasma pneumoniae infection, and asthmaThe Journal of Allergy and Clinical Immunology, 119
-
Jinming Gao, Yao-guang Lin, C. Qiu, Yi-wen Liu, Yi Ma, Ying Liu (2003)
Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects.Chinese medical journal, 116 7
-
M. Salam, Pi-Chu Lin, E. Avol, James Gauderman, Frank Gilliland (2007)
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthmaThorax, 62
-
S. Møller-Larsen, M. Nyegaard, A. Haagerup, J. Vestbo, T. Kruse, A. Børglum (2008)
Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disordersThorax, 63
-
T. Boat (2007)
The future of pediatric research.The Journal of pediatrics, 151 5 Suppl
-
T. Howard, P. Whittaker, A. Zaiman, G. Koppelman, Jianfeng Xu, Marcus Hanley, D. Meyers, D. Postma, E. Bleecker (2001)
Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.American journal of respiratory cell and molecular biology, 25 3
-
M. Kennedy, Jennifer Loehle, A. Griffin, M. Doll, G. Kearns, J. Sullivan, D. Hein (2008)
Association of the Histamine N‐Methyltransferase C314T (Thr105Ile) Polymorphism with Atopic Dermatitis in Caucasian ChildrenPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 28
-
A. Sandilands, A. Terron-Kwiatkowski, P. Hull, G. O'Regan, T. Clayton, R. Watson, Thomas Carrick, A. Evans, H. Liao, Yiwei Zhao, L. Campbell, M. Schmuth, R. Gruber, A. Janecke, P. Elias, M. Steensel, I. Nagtzaam, M. Geel, P. Steijlen, C. Munro, D. Bradley, C. Palmer, F. Smith, W. McLean, A. Irvine, A. Irvine (2007)
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczemaNature Genetics, 39
- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Current Medicine Group, LLC
- Subject
- Medicine & Public Health; Otorhinolaryngology; Pneumology/Respiratory System; Allergology
- ISSN
- 1529-7322
- eISSN
- 1534-6315
- DOI
- 10.1007/s11882-009-0063-9
- Publisher site
- See Article on Publisher Site
Abstract
The aim of pediatric personalized medicine is to uniquely combine genetic variation with developmental stage and environmental exposure to provide a tailored preventive, diagnostic, and therapeutic regimen. Recent advances in genomic research have identified many genetic variants that may be related to allergic and inflammatory disease and therapeutic response. These include variants involved in immune response, barrier proteins, and medication response. Current evidence also suggests that the effect of genetic variation often depends on the developmental stage of a child and environmental exposure such as infection or tobacco smoke during a specific stage. Personalized medicine is a new and exciting field with the potential to significantly improve medical care for children and adults.
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: Oct 13, 2009