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Peptide Derivatives of Some Physiologically Active Substances

Peptide Derivatives of Some Physiologically Active Substances ISSN 0012-5008, Doklady Chemistry, 2019, Vol. 487, Part 1, pp. 173–176. © Pleiades Publishing, Ltd., 2019. Russian Text © The Author(s), 2019, published in Doklady Akademii Nauk, 2019, Vol. 487, No. 1. CHEMISTRY a, a a a V. P. Shevchenko *, L. A. Andreeva , I. Yu. Nagaev , and Academician N. F. Myasoedov Received December 5, 2018 Abstract—The synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deu- terated analogues was carried out. The condensation is accompanied by side reactions, which could be min- imized by optimizing the reaction conditions. The most versatile approach to the synthesis of Boc-Gly-Pro- Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deuterated analogues is condensation of Boc- Gly-Pro or Boc-Gly-[ H]Pro with the amino groups of dopamine, serotonin, and doxorubicin. For the introduction of hydrogen isotopes into ΔPro, hydrogenation of its aqueous solution followed by condensation of the reduced proline with Boc-GlyOSu is recommended. Mass spectrometry was used to determine the content of isotopomers in the deuterated products. DOI: 10.1134/S00125008190700 48 The targeted delivery of a biologically active sub- Gly-Pro-Dox), dopamine (Boc-Gly-Pro-DOPA), stance (drug) to a particular organ, i.e., directly to and serotonin (Boc-Gly-Pro-Srt), which play the body tissue to be treated, is a challenge. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Peptide Derivatives of Some Physiologically Active Substances

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Publisher
Springer Journals
Copyright
Copyright © 2019 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1134/S0012500819070048
Publisher site
See Article on Publisher Site

Abstract

ISSN 0012-5008, Doklady Chemistry, 2019, Vol. 487, Part 1, pp. 173–176. © Pleiades Publishing, Ltd., 2019. Russian Text © The Author(s), 2019, published in Doklady Akademii Nauk, 2019, Vol. 487, No. 1. CHEMISTRY a, a a a V. P. Shevchenko *, L. A. Andreeva , I. Yu. Nagaev , and Academician N. F. Myasoedov Received December 5, 2018 Abstract—The synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deu- terated analogues was carried out. The condensation is accompanied by side reactions, which could be min- imized by optimizing the reaction conditions. The most versatile approach to the synthesis of Boc-Gly-Pro- Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deuterated analogues is condensation of Boc- Gly-Pro or Boc-Gly-[ H]Pro with the amino groups of dopamine, serotonin, and doxorubicin. For the introduction of hydrogen isotopes into ΔPro, hydrogenation of its aqueous solution followed by condensation of the reduced proline with Boc-GlyOSu is recommended. Mass spectrometry was used to determine the content of isotopomers in the deuterated products. DOI: 10.1134/S00125008190700 48 The targeted delivery of a biologically active sub- Gly-Pro-Dox), dopamine (Boc-Gly-Pro-DOPA), stance (drug) to a particular organ, i.e., directly to and serotonin (Boc-Gly-Pro-Srt), which play the body tissue to be treated, is a challenge.

Journal

Doklady ChemistrySpringer Journals

Published: Aug 12, 2019

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