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Pediatric Drug Hypersensitivity

Pediatric Drug Hypersensitivity Purpose of Review Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management. Recent Findings This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β-lactam reactions. We review unique aspects of pediatric drug challenges and desensitizations. Summary It is important to accurately diagnose pediatric drug hypersensitivity reactions through a detailed history, physical examination, and available diagnostic testing. Understanding of the underlying mechanism leads to appropriate classification which is necessary to direct management. The decision to perform drug challenge, desensitization, or recommend avoidance of a medication can have a significant impact on a patient’s treatment. Utilization of weight-based dose and infusion rate adjustments for current drug challenge and desensitization protocols optimize success. . . . . . Keywords Pediatric Drug hypersensitivity Drug allergy Medication allergy Desensitization Drug challenge Introduction pediatric drug hypersensitivity reactions (DHRs) so children can receive the best available therapy and reduce unnecessary Drug reactions in children can be distressing to the child, avoidances. This review aims to present the current approach parent, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

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References (114)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-019-0841-y
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management. Recent Findings This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β-lactam reactions. We review unique aspects of pediatric drug challenges and desensitizations. Summary It is important to accurately diagnose pediatric drug hypersensitivity reactions through a detailed history, physical examination, and available diagnostic testing. Understanding of the underlying mechanism leads to appropriate classification which is necessary to direct management. The decision to perform drug challenge, desensitization, or recommend avoidance of a medication can have a significant impact on a patient’s treatment. Utilization of weight-based dose and infusion rate adjustments for current drug challenge and desensitization protocols optimize success. . . . . . Keywords Pediatric Drug hypersensitivity Drug allergy Medication allergy Desensitization Drug challenge Introduction pediatric drug hypersensitivity reactions (DHRs) so children can receive the best available therapy and reduce unnecessary Drug reactions in children can be distressing to the child, avoidances. This review aims to present the current approach parent, and

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: Feb 22, 2019

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