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Purpose In neurodegenerative clinical studies, patients are usually followed up for several years frequently examined in different MRI scanners and base magnetic fields. Technical specification differences in MRI scanners, e.g., acquisition protocols and spatial resolution, are two crucial limitations for longitudinal long-term cerebral atrophy investigations. Although widely known that MRI base magnetic field (B0) boldly affects brain tissue volume measurements, no systematic study has been proposed to maintain brain volume consistency through longitudinal exams. We propose a method to convert the measured volumes of segmented brain compartments from one MRI scanner with lower B0 and resolutions to volumes consistent with a higher resolution. Methods The proposed partial volume transfer (PVT) method is consistent with partial volume effect to correct the volume measures. The PVT demands at least one pair of simultaneous acquisitions on both MRI scanners to estimate three unknown coefficients completing the PVT system. We selected ten healthy subjects from a standard dataset on the web, ten other healthy subjects, and ten patients with multiple sclerosis diseases scanned by two different scanners, i.e., 1.5 T and 3.0 T from local hospital dataset, to evaluate the PVT. Results We obtained the mean relative errors ranging from 0.28 to 1.14%
Research on Biomedical Engineering – Springer Journals
Published: Mar 19, 2019
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