Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Huifang Lu and David Huston Partial Genomic Deletion of ICOS As a Cause of Hereditary Common Vari- able Immune Deficiency Grimbacher B, Hutloff A, Schlesier M, et al.: in other T-cell or B-cell costimulatory molecules constitute a Homozygous loss of ICOS is associated with adult- likely mechanism for other antibody deficiency disorders, onset common variable immunodeficiency. Nature such as CVID. The dysregulation of humoral immunity in Immunol 2003, 4:261–267. mice in whom the Icos gene locus was disrupted provided impetus for the hypothesis that defects in ICOS signaling Rating: Of outstanding importance. might cause CVID in some patients. Introduction: Common variable immunodeficiency Aims: To determine whether impaired expression of ICOS (CVID) includes a heterogeneous group of patients with is a cause of CVID. low serum immunoglobulins, impaired production of antigen-specific antibodies, and increased susceptibility to Methods: Peripheral blood mononuclear cells from 32 bacterial infections. CVID is the second most common CVID patients and 20 healthy controls were evaluated by primary immunodeficiency, with a prevalence of 1 in flow cytometry for T-cell expression of ICOS following mito- 30,000, and a peak onset at age 20 to 30 years. Seventy-five gen activation in vitro. T- and B-cell numbers and function percent
Current Allergy and Asthma Reports – Springer Journals
Published: May 30, 2003
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.