Access the full text.
Sign up today, get DeepDyve free for 14 days.
Jae-Yong Kim, S. Shim (2019)
Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of ActionBiomolecules & Therapeutics, 27
E. Fadl (2015)
Evaluation of the Effects of Aqueous Extracts of Some Sudanese Medicinal Plants on Culex Quinquefasciatus Say
S. Shehu, H. Ahmed, A. Sani (2019)
Evaluation of the effects of aqueous extract of Parkinsonia aculeata leaves on kidney and liver function indices in albino ratsNigerian Journal of Basic and Applied Sciences
B. Rocha, A. Ritter, Franciele Ames, O. Gonçalves, F. Leimann, L. Bracht, M. Natali, R. Cuman, C. Bersani-Amado (2017)
Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 86
H. McWatters, E. Kolmos, Anthony Hall, M. Doyle, P. Gyula, F. Nagy, A. Millar, S. Davis (2007)
of the circadian clock
D. Larrey (2000)
Drug-induced liver diseases.Journal of hepatology, 32 1 Suppl
Divya Singh, W. Cho, G. Upadhyay (2016)
Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An OverviewFrontiers in Physiology, 6
Cecília Almeida, T.C. Silva, Elba Amorim, M. Maia, U. Albuquerque (2005)
Life strategy and chemical composition as predictors of the selection of medicinal plants from the caatinga (Northeast Brazil)Journal of Arid Environments, 62
C. Culling (2013)
Handbook of Histopathological and Histochemical Techniques: Including Museum Techniques
Y. Guan, Qing He (2015)
Plants Consumption and Liver HealthEvidence-based Complementary and Alternative Medicine : eCAM, 2015
D. Webster, A. Bignell, E. Attwood (1974)
An assessment of the suitability of bromocresol green for the determination of serum albumin.Clinica chimica acta; international journal of clinical chemistry, 53 1
S. Ilavenil, N. Al-Dhabi, S. Srigopalram, Young Kim, P. Agastian, R. Baru, K. Choi, M. Arasu (2016)
Acetaminophen Induced Hepatotoxicity in Wistar Rats—A Proteomic ApproachMolecules, 21
R. Botting, S. Ayoub (2005)
COX-3 and the mechanism of action of paracetamol/acetaminophen.Prostaglandins, leukotrienes, and essential fatty acids, 72 2
.. S.W.Hassan, .. R.A.Umar, .. A.A.Ebbo, A. Akpeji, .. I.K.Matazu (2008)
Hepatoprotective Effect of Leaf Extracts of Parkinsonia aculeataL. Against CCl4 Intoxication in Albino RatsInternational Journal of Biological Chemistry, 2
(2019)
Unconjugated Hyperbilirubinemia
M. Porceddu, N. Buron, C. Roussel, G. Labbe, B. Fromenty, A. Borgne-Sanchez (2012)
Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver MitochondriaToxicological Sciences, 129
A. Gornall, C. Bardawill, M. David (1949)
Determination of serum proteins by means of the biuret reaction.The Journal of biological chemistry, 177 2
Sonia Sharma, A. Vig (2014)
Preliminary Phytochemical Screening and In Vitro Antioxidant Activities of Parkinsonia aculeata Linn.BioMed Research International, 2014
Atish Mukherji, S. Bailey, B. Staels, T. Baumert (2019)
The circadian clock and liver function in health and disease.Journal of hepatology, 71 1
L. Souza, L. Caputo, Ingrid Barros, F. Fratianni, F. Nazzaro, V. Feo (2016)
Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological ActivitiesInternational Journal of Molecular Sciences, 17
A. Kazemifar, A. Hajaghamohammadi, R. Samimi, Z. Alavi, E. Abbasi, Marjan Nassiri-Asl (2012)
Hepatoprotective Property of Oral Silymarin is Comparable to N-Acetyl Cysteine in Acetaminophen PoisoningGastroenterology Research, 5
E. Castrillón (2001)
Drug-induced liver toxicity.Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 93 7
D. Alvaro, A. Benedetti, L. Marucci, M. Monache, R. Monterubbianesi, Emanuele Cosimo, L. Perego, G. Macarri, S. Glaser, G. Sage, G. Alpini (2000)
The function of alkaline phosphatase in the liver: Regulation of intrahepatic biliary epithelium secretory activities in the ratHepatology, 32
Ana Leite, T. Araújo, B. Carvalho, M. Maia, V. Lima (2010)
Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)Evidence-based Complementary and Alternative Medicine : eCAM, 2011
H. Malloy, K. Evelyn (1937)
THE DETERMINATION OF BILIRUBIN WITH THE PHOTOELECTRIC COLORIMETERJournal of Biological Chemistry, 119
Eric Yoon, A. Babar, M. Choudhary, M. Kutner, N. Pyrsopoulos (2016)
Acetaminophen-Induced Hepatotoxicity: a Comprehensive UpdateJournal of Clinical and Translational Hepatology, 4
H. Jaeschke (2015)
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in PatientsDigestive Diseases, 33
I. Arias (2012)
Liver function from Y to Z.The Journal of clinical investigation, 122 8
Vasimahmed Lala, David Minter (1944)
LIVER FUNCTION TESTSMedical Journal of Australia, 1
B. Divya, K. Mruthunjaya, S. Manjula (2011)
Parkinsonia aculeata: a phytopharmacological review.Asian Journal of Plant Sciences, 10
S. Reitman, S. Frankel (1957)
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.American journal of clinical pathology, 28 1
P. Kind, E. King (1954)
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrineJournal of Clinical Pathology, 7
Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
Hepatotoxicity is considered a serious condition which can be progressed to liver damage. The hepatoprotective effect of Parkinsonia aculeata (PA) aqueous extract against acetaminophen (APAP)-induced hepatotoxicity was investigated. Wister albino rats were orally pre-treated with PA aqueous extract (250 mg/kg BW) for 14 days. A single toxic dose of APAP (800 mg/kg BW) was orally administered at the 13th day. Collection of blood samples was done for the biochemical analysis, and the hepatic tissue was collected for histopathological examinations. Our results indicate that PA aqueous extract exhibit a significant hepatoprotective effect by ameliorating APAP-induced alterations of serum aspartate transaminase (AST), alanine transaminase (ALT), total protein (TP), albumin (ALB), and bilirubin (total and indirect). Moreover, the prior administration of PA ameliorates the hepatotoxic changes induced by APAP as confirmed by liver histopathology. Taken together, the previous results demonstrated that the PA pretreatment provide significant hepatoprotective effect against the APAP-induced hepatotoxicity in animal models, thus PA could be a potential herbal medication that can be used in the future prevention of liver intoxication.
Comparative Clinical Pathology – Springer Journals
Published: Apr 16, 2020
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.