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Parkinsonia aculeata L. aqueous extract alleviated the hepatotoxicity induced by acetaminophen in albino rats

Parkinsonia aculeata L. aqueous extract alleviated the hepatotoxicity induced by acetaminophen in... Hepatotoxicity is considered a serious condition which can be progressed to liver damage. The hepatoprotective effect of Parkinsonia aculeata (PA) aqueous extract against acetaminophen (APAP)-induced hepatotoxicity was investigated. Wister albino rats were orally pre-treated with PA aqueous extract (250 mg/kg BW) for 14 days. A single toxic dose of APAP (800 mg/kg BW) was orally administered at the 13th day. Collection of blood samples was done for the biochemical analysis, and the hepatic tissue was collected for histopathological examinations. Our results indicate that PA aqueous extract exhibit a significant hepatoprotective effect by ameliorating APAP-induced alterations of serum aspartate transaminase (AST), alanine transaminase (ALT), total protein (TP), albumin (ALB), and bilirubin (total and indirect). Moreover, the prior administration of PA ameliorates the hepatotoxic changes induced by APAP as confirmed by liver histopathology. Taken together, the previous results demonstrated that the PA pretreatment provide significant hepatoprotective effect against the APAP-induced hepatotoxicity in animal models, thus PA could be a potential herbal medication that can be used in the future prevention of liver intoxication. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Parkinsonia aculeata L. aqueous extract alleviated the hepatotoxicity induced by acetaminophen in albino rats

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References (33)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag London Ltd., part of Springer Nature 2020
eISSN
1618-565X
DOI
10.1007/s00580-020-03102-2
Publisher site
See Article on Publisher Site

Abstract

Hepatotoxicity is considered a serious condition which can be progressed to liver damage. The hepatoprotective effect of Parkinsonia aculeata (PA) aqueous extract against acetaminophen (APAP)-induced hepatotoxicity was investigated. Wister albino rats were orally pre-treated with PA aqueous extract (250 mg/kg BW) for 14 days. A single toxic dose of APAP (800 mg/kg BW) was orally administered at the 13th day. Collection of blood samples was done for the biochemical analysis, and the hepatic tissue was collected for histopathological examinations. Our results indicate that PA aqueous extract exhibit a significant hepatoprotective effect by ameliorating APAP-induced alterations of serum aspartate transaminase (AST), alanine transaminase (ALT), total protein (TP), albumin (ALB), and bilirubin (total and indirect). Moreover, the prior administration of PA ameliorates the hepatotoxic changes induced by APAP as confirmed by liver histopathology. Taken together, the previous results demonstrated that the PA pretreatment provide significant hepatoprotective effect against the APAP-induced hepatotoxicity in animal models, thus PA could be a potential herbal medication that can be used in the future prevention of liver intoxication.

Journal

Comparative Clinical PathologySpringer Journals

Published: Apr 16, 2020

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