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- Publisher
- Springer Journals
- Copyright
- Copyright © 2002 by Adis International Limited
- Subject
- Pharmacy; Pharmacy
- ISSN
- 1175-6357
- DOI
- 10.2165/00024669-200201010-00001
- Publisher site
- See Article on Publisher Site
Abstract
Based on the frequent inactivation of the p53 gene product in human malignancy, and its functional involvement in tumor suppression, cell cycle control and apoptosis, p53 was identified as an attractive target for somatic gene therapy strategies in cancer. Several pilot and phase I studies explored the intratumoral injection of viral expression vectors encoding the p53 cDNA in patients with advanced cancer. These studies confirmed the safety and feasibility of this approach. Further, vector-specific transgene expression and surrogate markers for biological activity of the transgene were demonstrated. Local tumor regression, or stabilization of tumor growth, were observed in some studies, and were interpreted as evidence for clinical activity. No formal assessment of in vivo transduction efficacy and vector distribution, following intratumoral injection of p53 expression vectors, was performed.
Journal
American Journal of Cancer – Springer Journals
Published: Aug 9, 2012