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P21 - Evaluation of modifications in SCORMA Index and grading in the follow-up of a pediatric population with mastocytosis

P21 - Evaluation of modifications in SCORMA Index and grading in the follow-up of a pediatric... Del Mastro et al. Clinical and Translational Allergy 2014, 4(Suppl 1):P76 http://www.ctajournal.com/content/4/S1/P76 POSTER PRESENTATION Open Access P21 - Evaluation of modifications in SCORMA Index and grading in the follow-up of a pediatric population with mastocytosis 1* 1 2 1 1 Andrea Del Mastro , Angelica Petraroli , Diomira Magliacane , Veronica Squeglia , Carmela Gravante , 3 1 1 Alessandro Barbarino , Giuseppe Spadaro , Gianni Marone From 3rd Pediatric Allergy and Asthma Meeting (PAAM) Athens, Greece. 17-19 October 2013 Background changed (ΔSC-I > 10) and unchanged (ΔSC-I ≤ 10) in two Mastocytosis is a rare disease affecting both children and groups (Grading modified and unmodified). adults. It is characterized by accumulation of mast-cells in the skin and/or other tissues so that two main variants Results are distinguished: cutaneous (CM) and systemic (SM) We found r = 0, 47 (p < 0,05) and r =0,36 (p < 0,05), 1 2 mastocytosis. Most pediatric patients have primarily CM while there was no statistical difference in ΔSC-I in the and complete remission will develop in a considerable two groups (p < 0,05). number of patients during puberty. Less frequently, skin lesions persist and these patients are often diagnosed Conclusion with SM in adulthood. According to our data, in pediatric patients with mastocy- Our study investigates the correlation between tosis SC-I and Grading show a moderate correlation SCORMA (SCORing MAstocytosis) Index (SC-I), a scor- at first visit which weakens not significantly at the subse- ing system that assesses the clinical extent and intensity quent assessment after 2 years. Moreover, SC-I modifica- of cutaneous mastocytosis, and Grading system, that eval- tions (ΔSC-I) seemto be independentfromGrading uates skin-specific symptoms and treatment status, in the modifications and, as a consequence, from the clinical follow-up of pediatric patients with mastocytosis. Further- evolution of disease. more, we evaluate the role of SC-I modifications in the assessment of the severity of disease. Authors’ details Division of Allergy and Clinical Immunology, University of Naples Federico Methods II, Naples, Italy. Division of Allergy and Respiratory Disease, Hospital of Battipaglia, Salerno, Italy. Division of Preventive Medicine, University of Twenty-two patients aged less than 12 years were enrolled Naples Federico II, Italy. from our centre. SC-I and Grading were assessed for each patient at first visit and after 2 years, with determination Published: 28 February 2014 of Grading modifications and calculation of differences in absolute value of SC-I (ΔSC-I). Data were analyzed using SPSS software. Pearson’s correlation coefficient (r)was doi:10.1186/2045-7022-4-S1-P76 Cite this article as: Del Mastro et al.: P21 - Evaluation of modifications in used to assess the relationship between SC-I and Grading SCORMA Index and grading in the follow-up of a pediatric population at first visit (r ) and after 2 years (r ). Chi-square test was 1 2 with mastocytosis. Clinical and Translational Allergy 2014 4(Suppl 1):P76. performed to evaluate the association of ΔSC-I with Grading modifications, by dividing patients with SC-I Division of Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy Full list of author information is available at the end of the article © 2014 Del Mastro et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Allergy Springer Journals

P21 - Evaluation of modifications in SCORMA Index and grading in the follow-up of a pediatric population with mastocytosis

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Del Mastro et al; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
2045-7022
DOI
10.1186/2045-7022-4-S1-P76
Publisher site
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Abstract

Del Mastro et al. Clinical and Translational Allergy 2014, 4(Suppl 1):P76 http://www.ctajournal.com/content/4/S1/P76 POSTER PRESENTATION Open Access P21 - Evaluation of modifications in SCORMA Index and grading in the follow-up of a pediatric population with mastocytosis 1* 1 2 1 1 Andrea Del Mastro , Angelica Petraroli , Diomira Magliacane , Veronica Squeglia , Carmela Gravante , 3 1 1 Alessandro Barbarino , Giuseppe Spadaro , Gianni Marone From 3rd Pediatric Allergy and Asthma Meeting (PAAM) Athens, Greece. 17-19 October 2013 Background changed (ΔSC-I > 10) and unchanged (ΔSC-I ≤ 10) in two Mastocytosis is a rare disease affecting both children and groups (Grading modified and unmodified). adults. It is characterized by accumulation of mast-cells in the skin and/or other tissues so that two main variants Results are distinguished: cutaneous (CM) and systemic (SM) We found r = 0, 47 (p < 0,05) and r =0,36 (p < 0,05), 1 2 mastocytosis. Most pediatric patients have primarily CM while there was no statistical difference in ΔSC-I in the and complete remission will develop in a considerable two groups (p < 0,05). number of patients during puberty. Less frequently, skin lesions persist and these patients are often diagnosed Conclusion with SM in adulthood. According to our data, in pediatric patients with mastocy- Our study investigates the correlation between tosis SC-I and Grading show a moderate correlation SCORMA (SCORing MAstocytosis) Index (SC-I), a scor- at first visit which weakens not significantly at the subse- ing system that assesses the clinical extent and intensity quent assessment after 2 years. Moreover, SC-I modifica- of cutaneous mastocytosis, and Grading system, that eval- tions (ΔSC-I) seemto be independentfromGrading uates skin-specific symptoms and treatment status, in the modifications and, as a consequence, from the clinical follow-up of pediatric patients with mastocytosis. Further- evolution of disease. more, we evaluate the role of SC-I modifications in the assessment of the severity of disease. Authors’ details Division of Allergy and Clinical Immunology, University of Naples Federico Methods II, Naples, Italy. Division of Allergy and Respiratory Disease, Hospital of Battipaglia, Salerno, Italy. Division of Preventive Medicine, University of Twenty-two patients aged less than 12 years were enrolled Naples Federico II, Italy. from our centre. SC-I and Grading were assessed for each patient at first visit and after 2 years, with determination Published: 28 February 2014 of Grading modifications and calculation of differences in absolute value of SC-I (ΔSC-I). Data were analyzed using SPSS software. Pearson’s correlation coefficient (r)was doi:10.1186/2045-7022-4-S1-P76 Cite this article as: Del Mastro et al.: P21 - Evaluation of modifications in used to assess the relationship between SC-I and Grading SCORMA Index and grading in the follow-up of a pediatric population at first visit (r ) and after 2 years (r ). Chi-square test was 1 2 with mastocytosis. Clinical and Translational Allergy 2014 4(Suppl 1):P76. performed to evaluate the association of ΔSC-I with Grading modifications, by dividing patients with SC-I Division of Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy Full list of author information is available at the end of the article © 2014 Del Mastro et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Journal

Clinical and Translational Allergy – Springer Journals

Published: Feb 28, 2014

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