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Oxidative biomarkers and lipid alterations in euthyroid and hypothyroid dogs

Oxidative biomarkers and lipid alterations in euthyroid and hypothyroid dogs In recent years, few reports suggest that the oxidative process may be present in hypothyroid patients; however, these reports were mostly contradictory and with very few data regarding canine patients. So, this investigation was designed to study oxidative stress alterations in both hypothyroid and euthyroid dogs. The study was conducted on thirteen dogs (six hypothyroid dogs and seven euthyroid dogs) with an age range of 4–7 years. Establishing hypothyroidism was based on clinical signs and results of thyroid hormones evaluation. Serum samples were taken from each animal for evaluation of free T4 (fT4), total T4 (TT4), thyroid-stimulating hormone (TSH), cholesterol, triglycerides, ALP, malondialdehyde (MDA), and total antioxidant capacity (TAC), and comparison between euthyroid data and hypothyroid data was made. There was a decrease in fT4 and TT4 in hypothyroid patients along with elevation in TSH, cholesterol, triglycerides, and ALP. Oxidative biomarkers showed significant (P ≤ 0.05) elevation in both MDA and TAC in the hypothyroid dog. Canine hypothyroidism is associated with oxidative stress manifested with elevation in MDA and TAC; this process is exasperated by hyperlipidemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Oxidative biomarkers and lipid alterations in euthyroid and hypothyroid dogs

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References (53)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature 2021
eISSN
1618-565X
DOI
10.1007/s00580-021-03219-y
Publisher site
See Article on Publisher Site

Abstract

In recent years, few reports suggest that the oxidative process may be present in hypothyroid patients; however, these reports were mostly contradictory and with very few data regarding canine patients. So, this investigation was designed to study oxidative stress alterations in both hypothyroid and euthyroid dogs. The study was conducted on thirteen dogs (six hypothyroid dogs and seven euthyroid dogs) with an age range of 4–7 years. Establishing hypothyroidism was based on clinical signs and results of thyroid hormones evaluation. Serum samples were taken from each animal for evaluation of free T4 (fT4), total T4 (TT4), thyroid-stimulating hormone (TSH), cholesterol, triglycerides, ALP, malondialdehyde (MDA), and total antioxidant capacity (TAC), and comparison between euthyroid data and hypothyroid data was made. There was a decrease in fT4 and TT4 in hypothyroid patients along with elevation in TSH, cholesterol, triglycerides, and ALP. Oxidative biomarkers showed significant (P ≤ 0.05) elevation in both MDA and TAC in the hypothyroid dog. Canine hypothyroidism is associated with oxidative stress manifested with elevation in MDA and TAC; this process is exasperated by hyperlipidemia.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Feb 7, 2021

Keywords: Hypothyroidism; Oxidant; Antioxidant; Cholesterol; Dogs

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