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Multiscale Modeling of Cancer: An Integrated Experimental and Mathematical Modeling Approach
- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Springer Science+Business Media New York
- Subject
- Mathematics; Calculus of Variations and Optimal Control; Optimization; Systems Theory, Control; Theoretical, Mathematical and Computational Physics; Mathematical Methods in Physics; Numerical and Computational Physics, Simulation
- ISSN
- 0095-4616
- eISSN
- 1432-0606
- DOI
- 10.1007/s00245-017-9414-4
- Publisher site
- See Article on Publisher Site
Abstract
We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn–Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient and surrounded by host tissue. The introduction of cytotoxic drugs into the system serves to eliminate the tumor cells and in this setting the concentration of the cytotoxic drugs will act as the control variable. Furthermore, we allow the objective functional to depend on a free time variable, which represents the unknown treatment time to be optimized. As a result, we obtain first order necessary optimality conditions for both the cytotoxic concentration and the treatment time.
Journal
Applied Mathematics and Optimization – Springer Journals
Published: Apr 13, 2017