After being recognized for their antineoplastic properties at the beginning of the last century, viruses are again being considered for use as therapeutic agents against cancer. Certain species of virus have a propensity to replicate within transformed cells, commonly rendered vulnerable because of tumor-specific defects in their defense against viral infection. Other viruses have been modified to tumor-specific growth conditions. Oncolytic viruses carry the promise to efficiently target cancer cells for destruction and spread throughout tumor tissue to reach distant neoplastic loci without causing collateral damage to healthy tissues.
American Journal of Cancer – Springer Journals
Published: Aug 10, 2012
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