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Oncolytic Viruses for Cancer Therapy

Oncolytic Viruses for Cancer Therapy After being recognized for their antineoplastic properties at the beginning of the last century, viruses are again being considered for use as therapeutic agents against cancer. Certain species of virus have a propensity to replicate within transformed cells, commonly rendered vulnerable because of tumor-specific defects in their defense against viral infection. Other viruses have been modified to tumor-specific growth conditions. Oncolytic viruses carry the promise to efficiently target cancer cells for destruction and spread throughout tumor tissue to reach distant neoplastic loci without causing collateral damage to healthy tissues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cancer Springer Journals

Oncolytic Viruses for Cancer Therapy

American Journal of Cancer , Volume 2 (5) – Aug 10, 2012

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Publisher
Springer Journals
Copyright
Copyright © 2003 by Adis Data Information BV
Subject
Pharmacy; Pharmacy
ISSN
1175-6357
DOI
10.2165/00024669-200302050-00002
Publisher site
See Article on Publisher Site

Abstract

After being recognized for their antineoplastic properties at the beginning of the last century, viruses are again being considered for use as therapeutic agents against cancer. Certain species of virus have a propensity to replicate within transformed cells, commonly rendered vulnerable because of tumor-specific defects in their defense against viral infection. Other viruses have been modified to tumor-specific growth conditions. Oncolytic viruses carry the promise to efficiently target cancer cells for destruction and spread throughout tumor tissue to reach distant neoplastic loci without causing collateral damage to healthy tissues.

Journal

American Journal of CancerSpringer Journals

Published: Aug 10, 2012

References