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A. Grollman, S. Shibutani, M. Moriya, Frederick Miller, Lin Wu, U. Moll, N. Suzuki, A. Fernandes, T. Rosenquist, Z. Medverec, K. Jakovina, B. Brdar, N. Slade, R. Turesky, Angela Goodenough, R. Rieger, M. Vukelić, B. Jelaković (2007)
Aristolochic acid and the etiology of endemic (Balkan) nephropathyProceedings of the National Academy of Sciences, 104
C. Tangtong, L. Qiao, D. Long, T. Voice (2013)
FATE AND TRANSPORT PROPERTIES OF ARISTOLOCHIC ACIDS AS POTENTIAL EXPOSURE AGENTS RESPONSIBLE FOR BALKAN ENDEMIC NEPHROPATHY
(1990)
Handbook of chemical proiperty estimation methods
Y. Chin, W. Weber, T. Voice (1986)
Determination of partition coefficients and aqueous solubilities by reverse phase chromatography—II: Evaluation of partitioning and solubility modelsWater Research, 20
C. Jafvert, J. Westall, E. Grieder, R. Schwarzenbach (1990)
Distribution of hydrophobic ionogenic organic compounds between octanol and water: organic acidsEnvironmental Science & Technology, 24
A. Leo, C. Hansch, David Elkins (1971)
Partition coefficients and their usesChemical Reviews, 71
(1899)
Ueber die allgemeinen osmotischen Eigenschaften der Zelle , ihre vermutlichen Ursachen und ihre Bedeutung fur die Physuikigue
Xiaofang Fu, Yi Liu, Wei Li, Yu Bai, Yiping Liao, Huwei Liu (2011)
Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary.Talanta, 85 1
J. Mccall (1975)
LIQUID-LIQUID PARTITION COEFFICIENTS BY HIGH-PRESSURE LIQUID CHROMATOGRAPHYChemInform, 6
D. Long, T. Voice (2007)
Role of exposure analysis in solving the mystery of Balkan endemic nephropathy.Croatian medical journal, 48 3
B. Nowosielski, J. Fein (1998)
Experimental study of octanol–water partition coefficients for2,4,6-trichlorophenol and pentachlorophenol: Derivation of an empirical model of chlorophenol partitioning behaviourApplied Geochemistry, 13
(1969)
Etiology of endemic nephropathy [in Serbo-Croatian
J. Mccall (1975)
Liquid-lipquid partition coefficients by high-pressure liquid chromatography.Journal of medicinal chemistry, 18 6
Shu-ying Han, Jun-qin Qiao, Yun-yang Zhang, H. Lian, Xin Ge (2012)
Determination of n-octanol/water partition coefficients of weak ionizable solutes by RP-HPLC with neutral model compounds.Talanta, 97
R. Schwarzenbach, P. Gschwend, D. Imboden (1993)
Environmental Organic Chemistry
H. Meyer (1899)
Zur Theorie der AlkoholnarkoseArchiv für experimentelle Pathologie und Pharmakologie, 42
C. Hansch, A. Leo (1979)
Substituent constants for correlation analysis in chemistry and biology
B. McDuffie (1981)
Estimation of octanol/water partition coefficients for organic pollutants using reverse-phase HPLCChemosphere, 10
C. Hansch, P. Maloney, T. Fujita, R. Muir (1962)
Correlation of Biological Activity of Phenoxyacetic Acids with Hammett Substituent Constants and Partition CoefficientsNature, 194
(2013)
Voice TC (2013) Fate and transport properties of aristolochic acids
Linda Lee, P. Rao, P. Nkedi-Kizza, J. Delfino (1990)
Influence of solvent and sorbent characteristics on distribution of pentachlorophenol in octanol-water and soil-water systems.Environmental Science & Technology, 24
J. Westall, C. Leuenberger, R. Schwarzenbach (1985)
Influence of pH and ionic strength on the aqueous-nonaqueous distribution of chlorinated phenolsEnvironmental Science & Technology, 19
N. Pavlović, V. Maksimović, J. Maksimović, W. Orem, C. Tatu, H. Lerch, J. Bunnell, E. Kostić, Diana Szilagyi, V. Paunescu (2013)
Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: links to the etiology of endemic (Balkan) nephropathyEnvironmental Geochemistry and Health, 35
P. Grover, R. Ryall (2005)
Critical appraisal of salting-out and its implications for chemical and biological sciences.Chemical reviews, 105 1
M. Kah, Colin Brown (2008)
LogD: lipophilicity for ionisable compounds.Chemosphere, 72 10
(1899)
Zur Theorie der Alkolnarkose
D. Brooke, A. Dobbs, N. Williams (1986)
Octanol: Water partition coefficients (P): Measurement, estimation, and interpretation, particularly for chemicals with P > 105Ecotoxicology and Environmental Safety, 11
(2013)
Possible heath impacts of naturally occuring uptake of aristolichic acids by maize
TG 442D (2000)
OECD GUIDELINE FOR THE TESTING OF CHEMICALS In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method
(1973)
A simple relationship between soil sorption of organic chemicals and their octanol/water partition coefficients
(2013)
Influence of pH and ionic-strength on the aque
The octanol–water partition coefficients (Kow) of the aristolochic acids, AA I and AA II, were determined using the traditional shake-flask method as a function of pH and ionic strength. These compounds have been implicated in the etiology of Balkan endemic nephropathy, but evidence of a plausible exposure pathway remains elusive, and research is constrained by the absence of critical physical–chemical parameters on these compounds. Apparent Kow values were determined across a range of pH and ionic strength conditions. The results show that the apparent Kow decreased by approximately four orders of magnitude as pH increased from 2 to 9. The pH dependence was well described by a simple model that calculated the apparent Kow based on the ionization fractions and intrinsic Kow values for the neutral and ionized species. Higher ionic strength solutions resulted in higher Kow values at high pH, but had no effect at low pH. These results suggest that transport of aristolochic acids will be highly dependent on pH and ionic strength, with significant aqueous-phase transport at neutral to slightly alkaline conditions, with the highest mobility occurring under low ionic strength conditions, and the possibility of significant partitioning to nonpolar phases, such as soil organic matter or plant material, at low pH. Much of the region where BEN is prevalent is a karst environment, and pH values are generally above 8, thus leaching and groundwater transport are favored, which can suggest possible exposure routes.
Aquatic Geochemistry – Springer Journals
Published: Sep 5, 2020
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