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C. Willer, Elizabeth Speliotes, R. Loos, Shengxu Li, C. Lindgren, I. Heid, S. Berndt, A. Elliott, A. Jackson, C. Lamina, G. Lettre, Noha Lim, H. Lyon, S. Mccarroll, Konstantinos Papadakis, L. Qi, J. Randall, R. Roccasecca, S. Sanna, P. Scheet, M. Weedon, E. Wheeler, J. Zhao, L. Jacobs, I. Prokopenko, N. Soranzo, Toshiko Tanaka, N. Timpson, P. Almgren, A. Bennett, R. Bergman, S. Bingham, L. Bonnycastle, Morris Brown, N. Burtt, P. Chines, L. Coin, F. Collins, J. Connell, C. Cooper, G. Smith, E. Dennison, Parimal Deodhar, P. Elliott, M. Erdos, K. Estrada, David Evans, Lauren Gianniny, C. Gieger, C. Gillson, C. Guiducci, Rachel Hackett, D. Hadley, A. Hall, A. Havulinna, J. Hebebrand, A. Hofman, B. Isomaa, K. Jacobs, T. Johnson, P. Jousilahti, Z. Jovanović, K. Khaw, P. Kraft, M. Kuokkanen, J. Kuusisto, J. Laitinen, E. Lakatta, J. Luan, R. Luben, M. Mangino, W. McArdle, T. Meitinger, A. Mulas, P. Munroe, Narisu Narisu, A. Ness, K. Northstone, S. O’Rahilly, C. Purmann, M. Rees, M. Ridderstråle, S. Ring, F. Rivadeneira, A. Ruokonen, M. Sandhu, J. Saramies, L. Scott, A. Scuteri, K. Silander, M. Sims, Kijoung Song, J. Stephens, Suzanne Stevens, H. Stringham, Y. Tung, T. Valle, C. Duijn, K. Vimaleswaran, P. Vollenweider, G. Waeber, C. Wallace, R. Watanabe, D. Waterworth, N. Watkins, J. Witteman, E. Zeggini, G. Zhai, M. Zillikens, D. Altshuler, M. Caulfield, S. Chanock, I. Farooqi, L. Ferrucci, J. Guralnik, A. Hattersley, F. Hu, M. Jarvelin, M. Laakso, V. Mooser, K. Ong, W. Ouwehand, V. Salomaa, N. Samani, T. Spector, T. Tuomi, J. Tuomilehto, M. Uda, A. Uitterlinden, N. Wareham, P. Deloukas, T. Frayling, L. Groop, R. Hayes, D. Hunter, K. Mohlke, L. Peltonen, D. Schlessinger, D. Strachan, H. Wichmann, M. McCarthy, M. Boehnke, I. Barroso, G. Abecasis, J. Hirschhorn (2009)
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Xinyuan Gao, H. Kuang, Xiaomin Liu, Xue-Yan Wang, Yanbing Pan, Xiao-Xin Ma (2008)
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L. Brunetti, G. Orlando, C. Ferrante, A. Chiavaroli, M. Vacca (2005)
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R. Granata, F. Settanni, David Gallo, L. Trovato, L. Biancone, V. Cantaluppi, R. Nano, M. Annunziata, P. Campiglia, E. Arnoletti, C. Ghè, M. Volante, M. Papotti, G. Muccioli, E. Ghigo (2008)
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R. Granata, David Gallo, R. Luque, A. Baragli, F. Scarlatti, C. Grande, Iacopo Gesmundo, J. Cordoba-Chacon, L. Bergandi, F. Settanni, G. Togliatto, M. Volante, S. Garetto, M. Annunziata, Belén Chanclón, Eleonora Gargantini, S. Rocchietto, L. Matera, G. Datta, M. Morino, M. Brizzi, H. Ong, G. Camussi, J. Castaño, M. Papotti, E. Ghigo (2012)
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Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathwayJournal of Cellular and Molecular Medicine, 21
Uxía Gurriarán-Rodríguez, Icia Santos-Zas, O. Al-Massadi, C. Mosteiro, Daniel Beiroa, R. Nogueiras, A. Crujeiras, L. Seoane, J. Señarís, T. García-Caballero, R. Gallego, F. Casanueva, Y. Pazos, J. Camiña (2012)
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Obestatin promotes proliferation and survival of adult hippocampal progenitors and reduces amyloid-β-induced toxicityMolecular and Cellular Endocrinology, 422
P. Kołodziejski, E. Pruszyńska‐Oszmałek, M. Sassek, P. Kaczmarek, D. Szczepankiewicz, M. Billert, P. Maćkowiak, M. Strowski, K. Nowak (2017)
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Inhibitory effect of obestatin on glucose-induced insulin secretion in rats.Biochemical and biophysical research communications, 369 3
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CALL FOR PAPERS Integrative and Translational Physiology: Integrative Aspects of Energy Homeostasis and Metabolic Diseases Neural and hormonal control of food hoarding
N. Talley (2002)
Dyspepsia: management guidelines for the millenniumGut, 50
E. Dağ, S. Aydin, Y. Ozkan, F. Erman, A. Dağlı, Mehtap Gurger (2010)
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N. Zhang, Chao Yuan, Ze Li, Jie Li, Xiang-wei Li, Cong Li, Rui Li, Shu-Ran Wang (2011)
Meta-Analysis of the Relationship Between Obestatin and Ghrelin Levels and the Ghrelin/Obestatin Ratio With Respect to ObesityThe American Journal of the Medical Sciences, 341
Wensong Li, Manli Chang, Mingli Qiu, Yang Chen, Xiaochen Zhang, Qiang Li, Can Cui (2019)
Exogenous obestatin decreases beta‐cell apoptosis and alfa‐cell proliferation in high fat diet and streptozotocin induced type 2 diabetic ratsEuropean Journal of Pharmacology, 851
Rim Hassouna, P. Zizzari, O. Viltart, Seung-Kwon Yang, R. Gardette, C. Videau, E. Badoer, J. Epelbaum, V. Tolle (2012)
A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in MicePLoS ONE, 7
B. Kanat, R. Ayten, S. Aydin, M. Girgin, Z. Çetinkaya, Y. Ilhan, M. Yur, Zekiye Çatak (2014)
Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 25 3
L. Brunetti, C. Nisio, L. Recinella, G. Orlando, C. Ferrante, A. Chiavaroli, S. Leone, P. Michele, R. Shohreh, M. Vacca (2010)
Obestatin inhibits dopamine release in rat hypothalamus.European journal of pharmacology, 641 2-3
T. Reinehr, G. Sousa, C. Roth (2007)
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M. Scrima, P. Campiglia, Cinzia Esposito, I. Gomez-Monterrey, E. Novellino, A. D'Ursi (2007)
Obestatin conformational features: a strategy to unveil obestatin's biological role?Biochemical and biophysical research communications, 363 3
M. Szlis, J. Polkowska, E. Skrzeczyńska, B. Przybył, A. Wójcik-Gładysz (2018)
Does obestatin modulate the hypothalamic appetite‐regulating network in peripubertal sheep?Journal of Animal Physiology and Animal Nutrition, 102
W. Pan, H. Tu, A. Kastin (2006)
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J. Szakács, K. Csabafi, N. Lipták, G. Szabó (2015)
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H. Cengiz, H. Dağdeviren, S. Çaypinar, Ammar Kanawati, S. Yildiz, M. Ekin (2015)
Plasma serotonin levels are elevated in pregnant women with hyperemesis gravidarumArchives of Gynecology and Obstetrics, 291
Chih‐Yen Chen, Wei-Jei Lee, Keong Chong, Shou-Dong Lee, Y. Liao (2012)
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V. Vergote, B. Baert, E. Vandermeulen, K. Peremans, H. Bree, G. Slegers, C. Burvenich, B. Spiegeleer (2008)
LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin.Journal of pharmaceutical and biomedical analysis, 46 1
S. Unniappan, M. Speck, T. Kieffer (2008)
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L. Brunetti, B. Michelotto, G. Orlando, M. Vacca (1999)
Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings.European journal of pharmacology, 372 3
E. Motorykina, E. Khirazova, M. Maslova, A. Graf, A. Maklakova, A. Bayzhumanov, O. Kurko, L. Andreeva, N. Sokolova, N. Myasoedov, A. Kamenskii (2016)
Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4Bulletin of Experimental Biology and Medicine, 161
Y. Gutiérrez-Grobe, Israel Villalobos-Blasquez, K. Sánchez-Lara, A. Villa, G. Ponciano-Rodríguez, Martha Ramos, N. Chavez-Tapia, M. Uribe, N. Méndez-Sánchez (2010)
High ghrelin and obestatin levels and low risk of developing fatty liver.Annals of hepatology, 9 1
M. Fujimiya, K. Ataka, A. Asakawa, Chih‐Yen Chen, I. Kato, A. Inui (2012)
Regulation of Gastroduodenal Motility: Acyl Ghrelin, Des-Acyl Ghrelin and Obestatin and Hypothalamic PeptidesDigestion, 85
G. Aly, N. Hassan, Ghada Anwar, H. Ahmed, S. El-Masry, Rokia El-Banna, Nihad Ahmed, Ayat Kamal, Reham Tarkan (2020)
Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control studyJournal of Pediatric Endocrinology and Metabolism, 33
Jian Zhang, Pei-Gen Ren, O. Avsian-Kretchmer, C. Luo, Rami Rauch, C. Klein, A. Hsueh (2005)
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food IntakeScience, 310
L. Brunetti, L. Recinella, G. Orlando, B. Michelotto, C. Nisio, M. Vacca (2002)
Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus.European journal of pharmacology, 454 2-3
Anusha Subasinghage, B. Green, P. Flatt, N. Irwin, C. Hewage (2010)
Metabolic and structural properties of human obestatin {1–23} and two fragment peptidesPeptides, 31
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Position of the American Dietetic Association: nutrition intervention in the treatment of anorexia nervosa, bulimia nervosa, and eating disorders not otherwise specified (EDNOS).Journal of the American Dietetic Association, 101 7
L. Jiao, L. Jiao, Amy González, P. Hartge, R. Pfeiffer, Yikyung Park, D. Freedman, M. Gail, M. Alavanja, D. Albanes, L. Freeman, W. Chow, Wen-Yi Huang, R. Hayes, J. Hoppin, B. Ji, M. Leitzmann, M. Linet, Cari Meinhold, C. Schairer, A. Schatzkin, J. Virtamo, S. Weinstein, W. Zheng, R. Stolzenberg-Solomon (2010)
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsCancer Causes & Control, 21
W. Samson, G. Yosten, J. Chang, A. Ferguson, M. White (2008)
Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis.The Journal of endocrinology, 196 3
L. Brunetti, S. Leone, G. Orlando, L. Recinella, C. Ferrante, A. Chiavaroli, C. Nisio, Pierpaolo Michele, M. Vacca (2009)
Effects of obestatin on feeding and body weight after standard or cafeteria diet in the ratPeptides, 30
H. Millar, Fiona Wardell, Juliet Vyvyan, S. Naji, G. Prescott, J. Eagles (2005)
Anorexia nervosa mortality in Northeast Scotland, 1965-1999.The American journal of psychiatry, 162 4
新谷 光世 (2001)
Ghrelin,an Endogenous Growth Hormone Secretagogue,is a Novel Orexigenic Peptide that Antagonizes Leptin Action through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway
Ja Jung, J. Jeong, Ji Kim, S. Kim, S. Koh, B. Kim, Kook-Lae Lee (2015)
Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative ColitisIntestinal Research, 13
E. Taşkin, Bekir Atli, M. Kiliç, Y. Sari, S. Aydin (2014)
Serum, urine, and saliva levels of ghrelin and obestatin pre- and post-treatment in pediatric epilepsy.Pediatric neurology, 51 3
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Gastrointestinal diseases and eating disorders are among the most common pathologies in the world. One of the most widespread and dangerous consequence of many eating disorders is an uncontrolled weight gain that often leads to obesity. This review focuses on the 15-year-long studies of obestatin, one of the potential regulators of eating behavior. This peptide contains 23 amino-acids and appears due to the processing of the preproghrelin gene responsible for the coding of another orexigenic protein ghrelin. Obestatin and ghrelin have multiple physiological functions, including appetite regulation. Obestatin was originally obtained from the gastric mucosa in rats, but subsequent studies showed that it could be expressed in various tissues and had different effects in various organs and tissues. This review emphasizes possible anorexigenic effects of this peptide and their mechanisms. Despite the 15 years of research on obestatin, its influence on different organs and the mechanism of anorexigenic effects in particular bring about a lot of discussion. This is primarily due to the ambiguity of the peptide receptors’ determination and is also related to the possible degradation of the molecule into small fragments, which, in turn, can have their own effects. The local effects of obestatin and its derivatives in peripheral tissues and the possible effect at the central level indicate the potential of these peptides for further studies. For example, these compounds can be considered as the potential therapeutic compounds for eating disorders’ treatment. The aim of this work was to describe the relevance of the problem associated with obesity treatment and to summarize the results of numerous studies on obestatin and its fragments and their effects on appetite regulation in order to explain its possible mechanisms.
Moscow University Biological Sciences Bulletin – Springer Journals
Published: Apr 15, 2020
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