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Novel synthesis of PVA/GA hydrogel microspheres based on microfluidic technology

Novel synthesis of PVA/GA hydrogel microspheres based on microfluidic technology The hydrogel microspheres of polyvinyl alcohol (PVA)/ glutaraldehyde (GA) used as embolic agent can be applied in the embolization therapy. The mechanical properties and size precision of the hydrogel microspheres have a strong influence on its clinical application. In this work, the microfluidic technology was employed in the preparation of size-controlled PVA/GA hydrogel microspheres, and a novel in-situ gelation system was proposed. The influences of cross-linker (GA) content and the total content of PVA and GA in the dispersed phase, and catalyst content in the continuous phase on the compressive strength and deformation of PVA/GA gel microspheres were investigated in detail. Also, the kinetic behaviours of the formation of PVA/GA hydrogel microspheres in the microfluidic system were studied, and the results indicated that the gelation processes based on microfluidics accord to first-order reaction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Novel synthesis of PVA/GA hydrogel microspheres based on microfluidic technology

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Publisher
Springer Journals
Copyright
Copyright © Akadémiai Kiadó 2020
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-020-00101-w
Publisher site
See Article on Publisher Site

Abstract

The hydrogel microspheres of polyvinyl alcohol (PVA)/ glutaraldehyde (GA) used as embolic agent can be applied in the embolization therapy. The mechanical properties and size precision of the hydrogel microspheres have a strong influence on its clinical application. In this work, the microfluidic technology was employed in the preparation of size-controlled PVA/GA hydrogel microspheres, and a novel in-situ gelation system was proposed. The influences of cross-linker (GA) content and the total content of PVA and GA in the dispersed phase, and catalyst content in the continuous phase on the compressive strength and deformation of PVA/GA gel microspheres were investigated in detail. Also, the kinetic behaviours of the formation of PVA/GA hydrogel microspheres in the microfluidic system were studied, and the results indicated that the gelation processes based on microfluidics accord to first-order reaction.

Journal

Journal of Flow ChemistrySpringer Journals

Published: Sep 2, 2020

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