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Novel 1,2,4-thiadiazoles with an NO-producing fragment

Novel 1,2,4-thiadiazoles with an NO-producing fragment ISSN 00125008, Doklady Chemistry, 2010, Vol. 435, Part 2, pp. 311–313. © Pleiades Publishing, Ltd., 2010. Original Russian Text © I.V. Serkov, A.N. Proshin, L.N. Petrova, S.O. Bachurin, 2010, published in Doklady Akademii Nauk, 2010, Vol. 435, No. 4, pp. 479–481. CHEMISTRY I. V. Serkov, A. N. Proshin, L. N. Petrova, and Corresponding Member of the RAS S. O. Bachurin Received June 9, 2010 DOI: 10.1134/S0012500810120013 At present, the design of hybrid multitarget phar cals, for example, NOdonor drugs based on Tacrine, is also applied for this purpose [3]. maceuticals by introduction of nitric oxideproducing One of promising approaches to search for phar fragment in a molecule of known medicinal agent is maceuticals for the treatment of Alzheimer disease one of promising directions of medicinal chemistry and related neurodegenerative disorders is the search [1]. Nitric oxide (NO) is an endogenous signaling for blocking agents for glutamatemediated influx of molecule with a wide spectrum of biological activity 2+ Ca [4]. and plays an important role in nervous system func In recent time, molecules containing a thiadiazole tioning. Therefore, NO donors are used for the treat pharmacophore fragment and showing interesting ment of different neurodegenerative disorders, Alzhe pharmacological properties, including neuroprotec http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Novel 1,2,4-thiadiazoles with an NO-producing fragment

Serkov, I.; Proshin, A.; Petrova, L.; Bachurin, S.
Doklady Chemistry , Volume 435 (2) – Jan 8, 2011
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References (4)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Pleiades Publishing, Ltd.
Subject
Chemistry; Industrial Chemistry/Chemical Engineering; Chemistry/Food Science, general
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1134/S0012500810120013
Publisher site
See Article on Publisher Site

Abstract

ISSN 00125008, Doklady Chemistry, 2010, Vol. 435, Part 2, pp. 311–313. © Pleiades Publishing, Ltd., 2010. Original Russian Text © I.V. Serkov, A.N. Proshin, L.N. Petrova, S.O. Bachurin, 2010, published in Doklady Akademii Nauk, 2010, Vol. 435, No. 4, pp. 479–481. CHEMISTRY I. V. Serkov, A. N. Proshin, L. N. Petrova, and Corresponding Member of the RAS S. O. Bachurin Received June 9, 2010 DOI: 10.1134/S0012500810120013 At present, the design of hybrid multitarget phar cals, for example, NOdonor drugs based on Tacrine, is also applied for this purpose [3]. maceuticals by introduction of nitric oxideproducing One of promising approaches to search for phar fragment in a molecule of known medicinal agent is maceuticals for the treatment of Alzheimer disease one of promising directions of medicinal chemistry and related neurodegenerative disorders is the search [1]. Nitric oxide (NO) is an endogenous signaling for blocking agents for glutamatemediated influx of molecule with a wide spectrum of biological activity 2+ Ca [4]. and plays an important role in nervous system func In recent time, molecules containing a thiadiazole tioning. Therefore, NO donors are used for the treat pharmacophore fragment and showing interesting ment of different neurodegenerative disorders, Alzhe pharmacological properties, including neuroprotec

Journal

Doklady Chemistry – Springer Journals

Published: Jan 8, 2011

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