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Noise-induced bistable switching dynamics through a potential energy landscape

Noise-induced bistable switching dynamics through a potential energy landscape Abstract Interlinked positive feedback loops, an important building block of biochemical systems, can induce bistable switching, leading to long-lasting state changes by brief stimuli. In this work, prevalent mutual activation between two species as another positive feedback is added to a generic interlinked positive-feedback-loop model originating from many realistic biological circuits. A stochastic fluctuation of the positive feedback strength is introduced in a bistable interval of the feedback strength, and bistability appears for the moderate feedback strength at a certain noise level. Stability analysis based on the potential energy landscape is further utilized to explore the noise-induced switching behavior of two stable steady states. Graphical Abstract Prevalent mutual activation between two species A and B as another positive feedback is added to a generic interlinked positive-feedback-loop model originating from many realistic biological circuits. A stochastic fluctuation of the positive feedback strength is introduced to investigate noise-induced bistable switching dynamics in a bistable interval of the positive feedback strength. Stability analysis based on the potential energy landscape is used to explore the noise-induced switching behavior of these two stable steady states. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Acta Mechanica Sinica" Springer Journals

Noise-induced bistable switching dynamics through a potential energy landscape

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References (23)

Publisher
Springer Journals
Copyright
2015 The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg
ISSN
0567-7718
eISSN
1614-3116
DOI
10.1007/s10409-015-0400-2
Publisher site
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Abstract

Abstract Interlinked positive feedback loops, an important building block of biochemical systems, can induce bistable switching, leading to long-lasting state changes by brief stimuli. In this work, prevalent mutual activation between two species as another positive feedback is added to a generic interlinked positive-feedback-loop model originating from many realistic biological circuits. A stochastic fluctuation of the positive feedback strength is introduced in a bistable interval of the feedback strength, and bistability appears for the moderate feedback strength at a certain noise level. Stability analysis based on the potential energy landscape is further utilized to explore the noise-induced switching behavior of two stable steady states. Graphical Abstract Prevalent mutual activation between two species A and B as another positive feedback is added to a generic interlinked positive-feedback-loop model originating from many realistic biological circuits. A stochastic fluctuation of the positive feedback strength is introduced to investigate noise-induced bistable switching dynamics in a bistable interval of the positive feedback strength. Stability analysis based on the potential energy landscape is used to explore the noise-induced switching behavior of these two stable steady states.

Journal

"Acta Mechanica Sinica" – Springer Journals

Published: Apr 1, 2015

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